Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"brain delivery"”.
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Nose to Brain Delivery of Therapeutic Agents
… and do not allow frequent administration. Brain targeting of drugs by intranasal route is a safe and noninvasive method of drug delivery which allows frequent administration and is certainly more patient compliant than the currently folloinvasive methods. In this study, the plausibility of …
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A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy
… because they cannot efficiently cross the blood-brain barrier (BBB). The goal of this study is to develop a new transferrin conjugated nanoemulsion system (Tf-NE) for antiretroviral medication delivery and evaluate its potential to cross the BBB. Nanoemulsions were prepared based on the solvent …
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Development and Optimisation of Nanoparticulate System for Brain Delivery of L-DOPA
… this project was to design nanoparticulate drug delivery system by using poly (D, Llactide- co-glycolide) (PLGA) as a polymeric matrix for the delivery of LD across blood-brain barrier (BBB). Nanoparticles (NPs) provide a feasible choice as drug delivery device to cross the BBB because it may …
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Nanocarriers for nose-to-brain delivery: a novel strategy for the treatment of CNS disorders
… (CNS) disorders are still incurable. The blood-brain-barrier (BBB) precludes the delivery of drugs to the brain, preventing the therapy of a number of neurological disorders. In the last 20 years, intranasal (IN) administration has gained great attention in research and has been investigated …
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Molecular imaging with engineered physiology
… molecular-level measurements across the brain inside the intact organism are required. However, existing imaging strategies and available probes have been limited by serious constraints. Magnetic resonance imaging (MRI) provides deeper tissue penetration depth than optical imaging and …
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Preparazione e caratterizzazione di due sistemi carrier: beads a base di chitosano e chitosano/alginato; nanoparticelle di N-trimetilchitosano
… on the phytoterapic anti- inflammatory agent delivery. The main purpose of the present in vitro study is to have some information about their stability in the gastrointestinal tract and to formulate a drug delivery system for the oral administration of this phytoterapic agent. Alginate beads …
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From the body to the brain: Studying drug delivery and physiological interactions using MRI
The brain is in continuous communication with the rest of the body. Nerves connect the peripheral and central nervous system, and complex vasculature networks selectively permit passage of small molecules with an exogenous origin into the brain parenchyma. Although brain-body interactions underpin …
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Multifunctional Liposomal Carriers Encapsulating Temozolomide, RG7388 and Elacridar for Targeted Glioblastoma Multiforme Therapy
Glioblastoma multiforme is a grade IV brain tumour that is highly malignant and has a very low patient survival rate. A hurdle in glioblastoma therapy is bypassing the blood brain barrier. Thus, this study was aimed at designing and comparing two multifunctional liposomal therapies for the delivery …
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Transport of Antibodies and Nanoparticles across An in vitro Blood-Brain Barrier
"The blood-brain barrier (BBB) is a dynamic interface between the blood circulation and the central nervous system (CNS). While it serves as a selective barrier to water and solutes to prevent the blood-borne toxins from entering into the brain tissue, it hinders the drug delivery to the CNS for …
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Progettazione e studi preformulativi di formulazioni nanotecnologiche per la somministrazione intranasale di composti neuroattivi
Le malattie del sistema nervoso centrale (SNC) (disturbi neurologici, neurodegenerativi e dell'umore) sono in rapido aumento e colpiscono un'alta percentuale della popolazione mondiale. I fattori eziologici possono essere genetici o provenienti dall'ambiente esterno, che perturbano l'omeostasi del …