Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"brain cancer"”.
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Redox Flow Iontophoresis for Brain Cancer Therapy
… limitation for the success of chemotherapy in brain cancer treatment is the blood brain barrier. It plays a pivotal role in protecting the central nervous system, but also significantly hinders the dose of cancer drugs which can be delivered into a tumour. One option for circumventing the blood …
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LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
<p>Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a …
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Bio-Inspired and Nanotechnology-Enabled Drug Delivery for Diabetes and Brain Cancer
… current treatment challenges facing diabetes and cancer patients. Two different systems were developed. The first system, an implantable closed-loop insulin delivery device, utilizes pH-responsive nanoparticles embedded within a glucose-sensing matrix to mimic the physiological delivery of …
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Plasmonic Detection of microRNA Biomarkers in Microfluidic Devices for Brain Cancer Non-Invasive Diagnosis
I gliomi sono tumori cerebrali aggressivi che causano un tasso di sopravvivenza molto basso per i pazienti, anche dopo la diagnosi. Lo sviluppo di una tecnica diagnostica affidabile, economica e non invasiva con effetti collaterali minimi, è una delle principali sfide mediche e sociali dell'UE. La …
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Nanoparticles for Simultaneous Assessment of Ros and Radiosensitization of Brain Cancer Cells for Improved Radiotherapy Outcomes
… modalities, highly radioresistant forms of cancer such as Glioblastoma Multiforme (GBM) remains a major clinical challenge due to poor prognostication. In the past decade, new forms of radiotherapy such as Nanoparticle-Mediated Radiation Therapy (NPRT) are under intense research as a new …
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Treatment of brain cancer and ischaemic stroke utilising High Intensity Focus Ultrasound (HIFU) guide with MRI
… focused ultrasound (HIFU) is utilized for cancer treatment (thermal mode) and treatment of ischaemic stroke (mechanical mode). These two applications were investigated in vitro and in vivo models. MRI was utilized to monitor the lesions created by HIFU either in thermal or cavitation mode …
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Exploring Interactions Between Malignant Brain Cancer Cells and the Tumor Microenvironment Following High-Frequency Irreversible Electroporation
… and clinical utility as a therapeutic for brain tumors, including gliomas. H-FIRE has been shown to induce precise, uniform ablation within the tumor tissue, as well as local changes to the tumor microenvironment and systemic changes to the immune landscape. Namely, disruption of the …
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Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.
<p>As the tenth leading cause of cancer death in the United States with a 6.8% five-year survival rate, glioblastoma multiforme (GBM) is a very deadly disease with a poor prognosis. Therefore, a curative treatment is in high demand. Among the widely used anti-metabolites (Chemotherapeutic agents, …
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Chemical Genetic Interrogation of Neural Stem Cells: Phenotype and Function of Neurotransmitter Pathways in Normal and Brain Tumor Initiating Neural Precursor Cells
… neural stem cells (NSCs) in the mammalian brain brings promise for the treatment of neurological diseases and has yielded new insight into brain cancer. The complete repertoire of signaling pathways that governs these cells however remains largely uncharacterized. This thesis describes how …
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Adapting a gelatin hydrogel platform to investigate glioblastoma progression
According to the World of Health Organization, cancer is the leading cause of death worldwide, responsible for approximately 1 in 6 deaths globally. In the United States alone, there are approximately 80,000 new cases of primary brain tumors diagnosed annually, with a third of those being malignant …
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Investigating the Applications of Electroporation Therapy for Targeted Treatment of Glioblastoma Multiforme Based on Malignant Properties of Cells
… (GBM) is the most common and lethal primary brain cancer with an average survival time of 15 months. GBM is considered incurable with even the most aggressive multimodal therapies and is characterized by near universal recurrence. Irreversible electroporation (IRE) is a cellular ablation …
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RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO
As a result of improvements in cancer therapy and health care, the population of long-term cancer survivors is growing. For these approximately 12 million long-term cancer survivors, brain metastases are a significant risk. Fractionated partial or whole-brain irradiation (fWBI) is often required to …
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ANALYSIS OF TUMOR SPECIFIC PROTEIN EXPRESSION IN GLIOBLASTOMA MULTIFORME (GBMs) TUMORS THROUGH IMMUNOHISTOCHEMISTRY
… and, unfortunately, the most fatal form of brain cancer. GBM tumors with isocitrate dehydrogenase-1 (IDH1) mutation being expressed, lead to higher survival rates in patients that also have full resection of the tumor and chemotherapy. Without this mutation, it is thought that tumors have a …
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Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
… mechanics. Here, we investigate the mechanics of brain and brain cancer cells, specifically focusing on how PEFs impact cell mechanics and PEF-induced blood-brain barrier disruption. In our first study, we investigate single-cell mechanical disruption of glioblastoma cells after reversible …
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Les perturbateurs endocriniens : les défis entourant la réglementation de ces substances chimiques au niveau international, canadien et européen
… 2 diabetes, breast, testicular, prostate and brain cancer, obesity, neurobehavioural disorders, but also gender imbalance, fertility disorders and the general decline of intelligence quotient. Pursuant to their intrinsic properties, EDs cannot be treated like any other chemicals, therefore, …
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IN VITRO MODEL OF GLIOBLASTOMA TO STUDY THE EFFECTS OF BRAIN MICROENVIRONMENT AND ITS MECHANICAL PROPERTIES ON TUMOR CELLS
… (GBM) is one of most aggressive forms of brain cancer with a median survival rate of 14.6 months, and the two-year survival rate is 30%, which has not seen significant improvement in the last 100 years. This low survival rate could be in part attributed to the fact that there is a lack of …
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In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery
Glioblastoma is a deadly brain cancer with discouraging standard of care. New methods like convection enhanced delivery and chimeric antigen receptor T cells (CAR-T) are promising treatments that can be translated to glioblastoma. In this study, CAR-T cell flow through a hydrogel was explored in …
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Characterization of A Novel Oncogenic Mirna Inhibitor In Cancer Therapy
<p>As cancer research continues to move towards more personalized methods, targeted inhibitors of oncogenic drivers of cancer are found to be an innovative and promising therapeutic approach. Previously thought to be undruggable regions of the genome, RNA has become an area of increasing interest …
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