Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"bradykinin"”.
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Die Mediatorfunktion von Bradykinin und Platelet-Activating Factor bei der globalen zerebralen Ischämie
… beiden Mediatoren Platelet-activating factor und Bradykinin bei der Aktivierung der Leukozyten-Endothelinteraktionen aufgeklärt werden. Es sollte dabei auch der Einfluss der Mikrozirkulationsstörungen und der beiden Mediatoren Platelet-activating factor und Bradykinin auf das neurologische Defizit …
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The effects of bradykinin and angiotensin II on the thoracic aorta vasa sasorum microcirculation system
… wall structure and function. Angiotensin II and bradykinin are two important vasoactive peptides, which produce vasoconstriction and vasodilatation, respectively. They can also change the permeability of microcirculation. In the present study, we documented the effect of different concentrations …
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¿PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE ATTACK¿
… several cases remain idiopathic. The role of bradykinin in increasing vascular permeability has been demonstrated in angioedema due to C1-inhibitor deficiency and in angioedema due to the treatment with angiotensin converting enzyme (ACE) inhibitors, while its involvement in idiopathic …
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Effects of ovokinin on isolated aortas of guinea pigs, normotensive and spontaneously hypertensive rats
… of the canine mesenteric artery through bradykinin B1 receptors. Bradykinin can mediate both vasorelaxation and vasocontraction depending upon the tissue or species investigated. The aim of this study was to characterize ovokinin further by determining whether the effects of this peptide, …
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Glia-neuron signaling
… from glia. It has been demonstrated that bradykinin causes a receptor-mediated release of excitatory amino acids (EAAs), glutamate and aspartate, from glial cultures obtained from dorsal root ganglia (DRG) together with an increase in the cytoplasmic level of glial free calcium. …
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The in vivo characterisation of a C-domain specific ACE inhibitor
… a role in the metabolism of vasodilatory peptide bradykinin. In the event of myocardial infarction (MI), cardiac output and blood pressure decreases, resulting in activation of the RAS and an increase in both Ang II production and bradykinin metabolism. While initially compensatory, prolonged RAS …
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Functional genomic study and bioinformatic analysis on natural bioactive peptides
… employed in this project. In chapter 3, a novel bradykinin-related peptide was isolated and identified from the skin secretion of odorrana livida using shotgun cloning and tandem mass spectrometry fragmentation sequencing approach. This peptide exhibited a dose-dependent contractile property on …
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Role of kinins in mediating vascular function in healthy pregnancy and pre-eclampsia
… demonstrated that in addition to classical bradykinin B2 receptor-mediated relaxation, a subset of healthy patients exhibited nitric oxide-dependent relaxation to the B1 receptor agonist Lys-des- Arg9-BK (LDABK) which could not be inhibited by either B1 or B2 receptor antagonists. Also, …
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Bioactive peptides from the defensive skin secretions of selected American and Asian frogs
… work on these bioactive substances such as bradykinin-related peptides and antimicrobial peptides, indicates that they have some clear clinical therapeutic implications including uses as anti-inflammatories, anti-bacterials and even anticancer agents. This project mainly focused on the …
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A Combined In Vivo and In Vitro Approach to the Study of Endotoxemia in Swine
… generation bronchi to substance P, carbachol, bradykinin and electric field stimulation was observed. However the increase in response to bradykinin and electric field stimulation were not statistically significant. Histopathology of the lungs demonstrated congestion, hemorrhage and …
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The role of renal afferent signalling in chronic intermittent hypoxia-induced sympathoexcitation and hypertension
… renal pelvic wall were chemically stimulated by bradykinin and capsaicin, or inhibited by bradykinin receptor type 1 (BK1R) and/or 2 (BK2R) blockers, and cardiovascular and RSNA responses were measured. Renal histology, inflammation and oxidative stress biomarkers were assessed. Results: …
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Prolylcarboxypeptidase protects from vascular dysfunction and promotes vascular repair
… peptides (including angiotensin II, des-Arg9-bradykinin and alpha-melanocyte stimulating hormone) and activates plasma prekallikrein. The enzyme is highly expressed by endothelial cells where it activates prekallikrein to liberate the vasoactive peptide bradykinin. The following studies …
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The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
… mechanism, ACE also inactivates the vasodilator bradykinin. The main overall effect of these actions is an increase in blood pressure. Several ACF inhibitors have been developed as drugs for the treatment of myocardial infarction, hypertension, kidney failure and heart failure.
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Kinin System Activation in Vasculitis
… is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. Vasculitis is an autoimmune systemic inflammatory disease, characterized by leukocyte …
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Estudo comparativo do efeito de warifteína e metil-warifteína, alcaloides de Cissamplelos sympodialis ECHL (Menispermaceae), no processo inflamatório agudo.
… 30 and 60 minutes for PGE2 and 15 for 30min and bradykinin were measured with calipers . The vascular permeability was assessed by intraperitoneal injection of acetic acid, and protein concentrations were quantified spectrophotometrically using Evans blue . The cell migration was assessed by …
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Treating type 2 diabetes through insulin resistance
… studied included lipoic acid, isoferulic acid, bradykinin, lipid mobilising factor (provisionally synonymous with Zinca2 glycoprotein) and the trace elements lithium, selenium and chromium. The putative role of TNFa in insulin resistance was also investigated. Lipoic acid improved …
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The discovery of a novel bioactive peptide, QUB-1036, from the defensive skin secretion of Pelophylax kl. esculentus
… the novel peptide, QUB-1036, was found to be a bradykinin receptor agonist on rat bladder and uterus. This is one of the few reports of bioactive peptides from the temporin family which have stimulating effects on rat smooth muscles and further studies should focus on its mechanism of action. …
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Investigating novel therapeutic targets for treatment of visceral pain.
… SKA 31 had no effect on the response to ATP and bradykinin and colonic ramp distension. In contrast subsequent pre-treatment with the KCNQ channel opener retigabine inhibited the colonic afferent response to ATP, bradykinin and ramp distension. Furthermore, in a separate set of experiments …
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Effect of shear stress on surface membrane potassium ion permeability of calf pulmonary artery endothelial cells (Potassium ion)
… K$\sp+$ channels were shown to respond to bradykinin stimulation under flow conditions. The significance of such flow studies is that they provide more knowledge about the flow-associated changes in ionic channels and intracellular second messengers in endothelial cells.
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Studies on the angiotensin converting enzyme gene polymorphism and Ace inhibitors
… inhibition increases kinin level, for example bradykinin. Kinins have been proposed be involved in the pathogenesis of cough due to ACE inhibitors, a common adverse effect in those prescribed these drugs. A genetic link was proposed to explain the differing susceptibility of subjects to develop …
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