Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"boronic ester"”.
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Shockwave energy dissipation by mechanoresponsive materials
… the dynamic PDMS networks (PDMS-B-DR) containing boronic ester bonds, which allows self-healing via reversible bond exchange reactions are studied. By increasing the density of boronic ester bonds in PDMS-B-DR, lower peak pressures are measured, and its energy absorption capability outperforms …
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Investigations Into Cross-Coupling of Secondary Organoboronic Esters
Until recently, secondary organoboronic esters were not viable substrates in the Suzuki-Miyaura cross-coupling reaction; however under recently reported conditions from the Crudden group1, which includes the addition of silver oxide to a palladium/phosphine catalyst system, this coupling can now be …
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds
The first successful synthesis and isolation of a boronic acid was reported in 1860 by Frankland in the pursuit of novel organometallic compounds. For more than a century, further studies of boronic acids were sparsely published. Suzuki and Miyaura jumpstarted the field in 1979 with an innovative …
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Palladium-Catalysed Functionalisation of Csp3–H Bonds Directed by Aliphatic Amines
… set of amines were functionalised using alkenyl boronic ester coupling partners to give the desired olefinated products. The work includes enantioselective functionalisation using a chiral ligand and a preliminary study of stoichiometric aminoalkyl palladium(II) complexes.
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Prediction of higher selectivity catalysts by a computer driven workflow and machine learning and computational investigation of boronate esters in the Suzuki-Miyaura cross coupling
… quantum chemistry to elucidate the influence of boronic ester structure on the rate of transmetalation. Here we find that the activation barrier for transmetalation is dependent on the interplay between ground state destabilization of a Pd-O dative interaction and hyperconjugative activation of …
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Synthesis and Application of Boronic Acid Derivatives
Boronic acids are attractive synthetic intermediates and have been shown to be effective as inhibitors of various enzymes. In this project, the overarching goal is the selective inhibition of a protease present in the mitochondria known as human ClpXP. To study the potential selective inhibition of …
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Thiol-Norbornene Hydrogels With Tunable Mechanical Properties for Engineered Extracellular Matrices
… was designed to yield dynamically adaptable boronic ester bonds via partial enzymatic reaction. Thiol-norborne hydrogel was made to contain hydroxyl phenol as well as boronic acid residues within its network. MT, in this case was used to oxidize the hydroxy phenol moieties into DOPA, which …
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Synthesis of contorted nanographenes via multi-fold alkyne benzannulation reactions
… polycyclic aromatic hydrocarbons with diyne boronic ester gave polyalkyne precursors, which were subjected to multi-fold alkyne benzannulation reaction to af-ford larger, highly soluble contorted NGs. This work also proved the applicability InCl3 and AgNTf2 in the synthesis of up to six …
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Stereospecific Csp3 cross-coupling for modular polyketide synthesis
… class of activated beta-aryloxysilyl pinacol boronic ester nucleophiles were designed and shown to undergo highly stereospecific cross-coupling with aryl halides even when containing one of the most sterically hindered transmetalating carbons reported to date. While highly stereospecific, this …
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Transmetalation from boronic esters to arylpalladium complexes without prior hydrolysis – mechanistic studies and preparative applications in the anhydrous, Suzuki-Miyaura cross-coupling reaction
… pre-transmetalation intermediates incorporating boronic esters have been characterized, proving the competency of boronic esters to undergo transmetalation without prior hydrolysis. Boronic ester structure was found to have a significant impact on both pretransmetalation intermediate speciation …
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Photoredox C–C Cross-Coupling Reactions using Boronic Acid Derivatives
… as reagents in organic synthesis, the use of boronic acid derivatives to generate carbon-centred radicals remains elusive. This dissertation explores the utilisation of photoredox catalysis to generate carbon radicals from boronic acid derivatives and subsequently engage them in C–C …
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Nickel-catalyzed cross-coupling reactions involving secondary and tertiary alkyl nucleophiles
… has been converted into the corresponding boronic acid, trifluoroborate salt and another boronic ester. Aditionally, bis(neopentylglycolato)diboron has also been employed as the boron source.</p>
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Iridium-Catalyzed Enantioselective Allylation of Alkenyl Boronates
Organoboronic esters are highly functionalizable synthetic intermediates owing to their unique reactivity that allows for pre-complexation with organometallic reagents to form boronates, which can then engage in bimolecular reactions. Furthermore, incorporation of boronic esters into their …
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Design and synthesis of novel biologically active flavones and isoflavones
… borylative reaction followed by immediate esterification to furnish the benzopyran core with a boronic ester at 3-position. Subsequent Suzuki-Miyaura coupling reaction allowed for the attachment of various aromatic systems, giving access to 4-arylisoflavenes which were readily converted to …
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I. Reaction mining—a next-generation platform for reaction discovery II. Rapid, anhydrous, homogenous Suzuki-Miyaura cross-coupling of aryl and alkylboronates
… and B-alkyl Suzuki-Miyaura cross-coupling of boronic esters and boronates. Chapter 1 describes previous efforts by Sarlah and Shved to accelerate the reaction discovery process with the combination of data science, HTE, and artificial isotope distributions. A workflow was subsequently designed …
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Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures
… the introduction, we present the synthesis of boronic ester-crosslinked BASPs that selectively disassemble into bottlebrush fragments upon exposure to hydrogen peroxide, which is often elevated in diseased tissue microenvironments. The H2O2-induced disassembly of spirocyclohexyl nitroxide …
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Evaluation and Development of Metal-Binding Agents that Alter Copper Bioavailability
… neoformans</italic>, while traditional metal sequestering agents had no effect on growth at the concentrations tested. In Chapter 3, various chemical properties of the select ligands that demonstrated Cu-dependent antifungal activity (8-hydroxyquinoline (8HQ), thiomaltol and pyrithione) were …
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Diastereoselective α-Alkylation of Chiral β-Borylated Esters
… for the α-alkylation of chiral β-borylated esters. We propose that standard deprotonation of chiral β-borylated esters with lithium diisopropylamide (LDA) leads to the formation of a boron"ate" intermediate that upon treatment with an alkylation reagent collapses to provide chiral α, …