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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"boron neutron capture therapy"”.
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Accelerator-based boron neutron capture therapy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1997.
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Boron neutron capture therapy treatment planning improvements
The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations …
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Hypoxia-selective compounds for boron neutron capture therapy
Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal …
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Radiobiology of normal rat lung in Boron Neutron Capture Therapy
Boron Neutron Capture Therapy (BNCT) is a binary cancer radiation therapy that utilizes biochemical tumor cell targeting and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal …
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Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy
… the radiobiological effectiveness of three new boron compounds namely a boronated porphyrin (BOPP) and two liposome formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro and in vivo comparisons that characterize compounds relative to boric acid and …
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Medical room design for a fission converter-based boron neutron capture therapy facility
A design of a shielded medical room to be used in Boron Neutron Capture Therapy was developed. The design included analytical shielding calculations, computational methods using the Monte Carlo N-particle transport code, and experimental measurements using the current medical room. The design …
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Lithium-6 filter for a fission converter-based Boron Neutron Capture Therapy irradiation facility beam
… method was used to measure the photon, thermal neutron and fast neutron dose. The measured advantage depth is 9.3 ± 0.1cm without filter and 9.9 ± 0.1cm with 8mm lithium-6 filter. The result is consistent with the result of Monte Carlo calculation.
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Beam characterization for accelerator-based boron neutron capture therapy using the ⁹Be(d,n) nuclear reaction
… ⁹Be(d,n) nuclear reaction for accelerator-based boron neutron capture therapies (AB-BNCT) was investigated. The moderated neutron spectra produced at several deuteron bombarding energies were evaluated in terms of dose rates and dosimetric profiles in a water-filled brain phantom using an …
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Sensitivity studies of the neutronic design of a fission converter-based ephithermal beam for boron neutron capture therapy
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1997.
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Design and dosimetry of epithermal neutron beams for clinical trials of boron neutron capture therapy at the MITR-II reactor
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1994.
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Conceptual engineering designs for a mechanical shutter, a medical room door, and a water shutter for a fission converter-based boron neutron capture therapy medical facility
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1999.
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Synthesis, Characterization, and Evaluation of Novel BODIPY Dyes With Theranostic Applications
Boron dipyrromethene (BODIPY) dyes, have garnered much attention in recent decades due to their enticing photophysical properties and their bioimaging applicability. Despite the progression of this field, the development of BODIPY based anti-cancer agents and radioimaging dyes has seen little …
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The effect of temperature on the bystander effect as examined in human prostate carcinoma cells with alpha particle irradiation
… during alpha-particle based therapies such as boron neutron capture therapy (BNCT) and tumor radioimmunotherapy and could provide a means to improve these therapies.
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Comparison of doses to normal brain in patients treated with boron neuron capture therapy at Brookhaven National Laboratory and MIT
A number of boron neutron capture therapy (BNCT) clinical trials are currently underway around the world. Due to the small number of patients at each of the individual centers, it is desirable to pool the clinical data from each into one patient database. Before this can be done, a number of …
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Biological dosimetry of neutron beams for neutron capture therapies
Boron neutron capture therapies using the 10B(n,a)7Li reaction have been proposed as treatments for glioblastoma multiforme, metastatic melanoma, rheumatoid arthritis, and other debilitating conditions. This thesis presents the first combined biological and physical dosimetry interbeam comparison …
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Synthesis, characterization and biological studies of carboranyl-porphyrin bioconjugates for treatment of brain tumors
… drug across the blood brain barrier (BBB), boron neutron capture therapy (BNCT) for brain tumors, application of carboranyl derivatives in attempt to treat brain tumors using BNCT. Chapter 2 involves synthesis, characterization and toxicity studies (In vitro and In vivo) of high boron …
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Computational aspects of treatment planning for neutron capture therapy
Boron Neutron Capture Therapy (BNCT) is a biochemically targeted form of binary radiation therapy that has the potential to deliver radiation to cancers with cellular dose selectivity. Accurate and efficient treatment planning calculations are essential to maximizing the efficacy of BNCT and …
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High Resolution Quantitative Auto-Radiography to determine microscopic distributions of B-10 in neutron capture therapy
The success of Boron Neutron Capture Therapy (BNCT) is heavily dependent on the microscopic distribution of B-10 in tissue. High Resolution Quantitative Auto-Radiography (HRQAR) is a potentially valuable analytical tool due to its ability to simultaneously visualize boron distributions and tissue …
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