Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"bone tumor"”.
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Urinary Volatile Organic Compounds for Detection of Breast Cancer and Monitoring Chemical and Mechanical Cancer Treatments in Mice
… volatile organic compounds in mammary pad or bone tumor mice models. Subsequently, it focuses on investigating the efficacy of therapeutic intervention through identified potential biomarkers. Methods for monitoring tumor development and treatment responses have technologically advanced over …
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Investigating the role of zoledronate for inhibition of osteosarcoma metastasis
Osteosarcoma (OS) is the most common primary bone tumor in dogs and it accounts for nearly 10% of all diagnosed canine cancers. Despite aggressive multimodality therapy, the mortality rate for canine OS exceeds 90% from the development of distant metastases to lungs and other visceral organs. Given …
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Application of a Periosteum-bone Allograft for Healing of Segmental Bone Defects
Whole bone allografts or autografts are commonly applied surgically to repair approximately 2.2 million segmental bone defects annually caused by trauma or bone tumor resection worldwide.[1] However, about 15-40% of these cases result in unsuccessful healing because of a persistent gap or nonunion …
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Identification Of Effective New Drugs Combinations Exploiting The Ability Of trabectedin To Modulate Transcription
… sarcoma (ES) is the second most common malignant bone tumor of childhood, characterized by the chimeric protein EWS-FLI1 (hallmark of this pathology), that alters the transcription of different genes. The five-year overall survival of patients with localized disease is approximately 70%; …
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SENSITIZATION OF HUMAN OSTEOSARCOMA CELL LINE 143B WITH CALCITRIOL FOR CISPLATIN THERAPY
… Osteosarcoma (OS) is the most predominant bone tumor in individuals between 10-25 yrs of age. Cisplatin is the most widely used chemotherapeutic agent for OS management, it significantly enhances the survival rate. Resistance to the drug, toxicities of high doses and metastasis are the …
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
Osteosarcoma is the most common primary malignant bone tumor in children, adolescents, and dogs. Lethality is due to lung metastases. Despite standard of care, patients with lung metastases have a survival rate of only 25%. Therefore, our lab studied potential therapeutics to target lung …
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Investigating the ablative and immunomodulatory effects of high frequency irreversible electroporation on osteosarcoma in-vitro
Osteosarcoma (OS) is the most common primary bone tumor with an annual incidence rate of 3-4 individuals per million particularly affecting children and young adults. The 5-year survival rate stands at 60-80% with the current standard of care for human OS patients who do not have metastatic disease …
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Improving Nk Cell Therapy For Osteosarcoma
<p>Osteosarcoma (OS) is the most common primary bone tumor. Despite new treatment options, 5-year survival for metastatic OS has remained at only 30% for the last 30 years. Adoptive transfer of Natural Killer (NK) cells holds promise for a new, non-toxic therapy for OS. NK cells are part of the …
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Expression of ICAM-1, MHC-1 and B7 surface molecules in canine primary appendicular osteosarcoma
… is the most common primary malignant bone tumor in dogs. The characteristic aggressive and highly metastatic behavior of this neoplasm indicates it has developed mechanisms to elude the immune surveillance system. The aim of the study was to determine whether canine primary …
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Characterizing the Effects of Histotripsy for Osteosarcoma Treatment on Tendon Structure and Function
Osteosarcoma (OS) is the most common malignant bone tumor in both humans and dogs. Current standards of care for OS consist of limb amputation, limb-salvage surgery, pre- and post-operative chemotherapy, and thermal ablation methods. While these methods are used to ablate and/or provide pain relief …
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Modeling Cancer Using Li-Fraumeni Syndrome Patient-Derived Induced Pluripotent Stem Cells
… the osteosarcoma phenotype, creating “a bone tumor in a dish”. This “tumor in a dish” platform proved that LFS is an ideal model system to study and modeling LFS associated malignancies.</p> <p>In this study, we applied whole exome deep sequencing in LFS iPSCs derived samples carrying …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… the original site to distant organs, such as bone, lung and liver. Tumor metastasis is responsible for nearly all of the morbidity and mortality associated with BC. Treatments of BC fail in the advanced stage, when metastases have already occurred. To mimic late stage BC in female patients, a …