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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"bone repair"”.
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Layer-by-Layer Systems for Craniomaxillofacial Bone Repair
The treatment of craniomaxillofacial bone defects with drug-eluting synthetic implants is a promising treatment currently being investigated. It is becoming increasingly recognized that release rate of growth factor proteins signaling bone regeneration and vascularization is a key optimization …
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Towards an autologous tissue engineering construct for craniofacial bone repair
Patients with critical-size bone defects, as a result of trauma, congenital malformations or tumor resections, generally have limited healing without clinical intervention. The autograft is the current standard of care for repair of these defects due to capacity for osteointegration and …
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Modification of mineralized collagen scaffolds to overcome challenges of craniomaxillofacial bone repair
Craniomaxillofacial defects are a class of bone defect or injury resulting in a large volume of bone missing from the skull or jaw which is unable to regenerate without surgical intervention. Examples of these include cleft palate birth defects, cancer resection, and high energy impact trauma such …
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Selective laser sintering of bioactive glass scaffolds and their biological assessment for bone repair
<p>"Bone scaffold fabrication using powder-bed based additive manufacturing techniques, like the selective laser sintering (SLS) process, provides control over pore interconnectivity, pore geometry, and the overall shape of the scaffold, which aids in repairing different regions of the bone. The …
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Employing mineralized collagen scaffolds in a patient-centric approach for improved craniomaxillofacial bone repair
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Development of collagen scaffolds to address biomechanical design criteria for tendon–to–bone repair
The tendon-bone junction (TBJ) is a unique, mechanically dynamic and structurally graded anatomical zone which transmits tensile loads between tendon and bone. The TBJ repeatedly transmits high tensile loads to result in movement without failure by effectively dissipating stress concentrations …
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Technology roadmapping and design optimization of an innovative mineral-organic adhesive for bone repair
… to the medical device industry, specifically bone adhesives; and, Development of a multidisciplinary design optimization model used for the development of a novel mineral-organic adhesive used in lumbar spine fusion procedures. A Multi-objective optimization found that an optimal design of the …
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Engineering Mussel Foot Protein 5 (MFP5) for Enhanced Adhesive Performance in Tendon and Bone Repair
… to improve tendon-to-tendon and tendon-to-bone adhesive outcomes. MFP5, known for its underwater adhesive properties, was synthesized using recombinant techniques and optimized through coacervation and cross-linking. Adhesion tests demonstrated the superior performance of the optimized MFP5 …
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Effects of tendon viscoelasticity on the distribution of forces across sutures in a model tendon-to-bone repair
… to the rotator cuff often require surgical repair. These repairs often culminate in re-tearing when sutures break through the tendon in the weeks following repair. Numerous studies have been performed to identify suturing strategies that reduce this risk by balancing forces across sutures. …
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The Role of Bisphosphonates and Osteoblast Lineage Cells in Promoting Osteogenic and Angiogenic Processes Necessary for Bone Repair
<p>Bone is a dynamic organ that readily undergoes bone formation and remodeling in response to its mechanical environment. This response is accelerated during injury such as full fracture and or stress fracture, where woven bone must rapidly form for successful repair and restoration of mechanical …
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The Role of Cell Communication and 3D Cell-Matrix Environment in a Stem Cell-Based Tissue Engineering Strategy for Bone Repair
The use of stem cells for the repair of bone and cartilage is a primary research interest in modern tissue engineering strategies. The goal of this doctoral thesis was to investigate the role of cell communication and mechanical stimulation in a 3D tissue engineered construct, and to determine …
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INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION
… in treating complicated wound with exposed bone (Wijewardena et al. 2011, DeFranzo et al. 2001). However, NPWT is not established as a treatment modality for orthopedic application and its mechanistic pathways of action on cellular activities is unknown. To support proper bone healing, the …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… associated with increased fracture risk, delayed bone healing and fracture non-union. Binge alcohol consumption has occurred in 25-40% of all orthopaedic trauma cases. The canonical Wnt pathway, through tight regulation of stabilized beta-catenin, plays an essential and pivotal role in the …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… has a limited endogenous ability for self-repair and current clinical treatments for damaged or diseased cartilage tissue are insufficient. Additionally, there is a biological and mechanical interplay between cartilage and the underlying subchondral bone, linking the …
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The influence of nanotopographical structures on osteoblast adhesion formation and the functional response of mesenchymal stem cell populations
… of persons over 50 years of age affected by bone diseases will double by 2020 (Navarro et al., 2008). Clearly this represents a need for permanent, temporary or biodegradable orthopaedic devices that are designed to substitute or guide bone repair. Polymeric medical devices are widely used in …
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MSC DERIVED EV IN REGENERATIVE MEDICINE
… patients suffering from osteoarthritis (OA) and bone fractures. Currently, there is no long-term therapy for OA; symptoms can be managed with anti-inflammatories and analgesics until they worsen to the extent that the damage becomes debilitating, and joint arthroplasty, is necessitated. However, …
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Polypyrrole : an interactive substrate for bone regeneration
Current methods of bone repair rely on autografts (bone from a donor site) and allografts (bone from human cadaver). However, these methods are plagued with disadvantages. There is a clear and urgent need to provide alternatives for regenerating and repairing bone. Bone is known to be one of the …
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Biomaterials for bone regeneration
… of hydroxyapatite (HA)-based biomaterials for bone repair: calcium phosphate microspheres and bioactive silicate glass scaffolds. These biomaterials were prepared with modified compositions and microstructures and then were evaluated for bone regeneration.</p> <p>The open HA microspheres with …
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Development of High Strength Dicalcium Phosphate Anhydrous Cement with Nanosilica Sol
… based materials have large potential as bone repair substitutes and drug delivery systems due to high bioactivity and known solubility in body fluid, and they could provide useful scaffolds in tissue engineering and orthopedic applications. Clinicians increasingly need bone scaffolds to …
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Wnt signaling in zebrafish fin regeneration : chemical biology using a GSK3β inhibitor
Bone growth can be impaired due to disease, such as osteoporosis. Currently, intermittent parathyroid hormone (PTH) treatment is the only approved therapy in the United States for anabolic bone growth in osteoporosis patients. The anabolic effects of PTH treatment are due, at least in part, to …
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