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Showing 1 to 19 of 19 for “"bone remodelling"”.
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Computational simulation of bone remodelling post reverse total shoulder arthroplasty
Bone is a living material. It adapts, in an optimal sense, to loading by changing its density and trabeculae architecture - a process termed remodelling. Implanted orthopaedic devices can significantly alter the loading on the surrounding bone. In addition, these devices rely on bone ingrowth to …
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Dual Roles for NBR1 in Bone Remodelling and Autophagosomal Protein Degradation
… degradation of polyubiquitinated proteins. -- In bone, Nbrl was previously identified as a key regulator of osteoblast differentiation and activity. The work described in this thesis strengthened these observations and highlighted that the interaction between Nbrl and p62 is also important for the …
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Various continuum bone remodelling algorithms applied to the proximal femur in two and three dimensions
This study investigates the behaviour of bone when it is subjected to mechanical loading. This is important in fields such as orthopaedics and implant design. Various models of bone remodelling are discussed, and a strain energy based as well as a strain remodelling based algorithm are applied in …
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Mathematical modelling of bone remodelling at the cellular level and the interaction between myeloma cells and the bone microenvironment
After an initial phase of growth and development, bone undergoes a continuous cycle of repair, renewal and optimization, by a process termed remodelling. Bone remodelling is the coordinated processes of resorption by osteoclasts and formation by osteoblasts, where old bone is replaced by new bone. …
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Reduced order modelling of bone resorption and formation.
The bone remodelling process, performed by the Bone Multicellular Unit (BMU) is a key multi-hierarchically regulated process, which provides and supports various functionality of bone tissue. It is also plays a critical role in bone disorders, as well as bone tissue healing following damage. …
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Computer simulation of the osteocyte and bone lining cell network and the effect of normal physiological changes in cellular functions on that network
… play a critical role in the regulation of bone remodelling by translating strain due to mechanical loading into biochemical signals transmitted through the interconnecting lacuno-canalicular network to bone lining cells (BLCs) on the bone surface. This work aims to examine the effects of …
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Orthodontic tooth movement and neurotrophins in the rat dento-alveolar complex.
… response. This response results in the remodelling of the periodontal ligament and the alveolar bone. When a force is placed on a tooth, the periodontal ligament is stretched and compressed depending on the direction of force. On the side where the ligament is stretched, a response …
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Orthodontische Verankerungskapazität von Orthosystem-Implantaten in der Mandibula : eine experimentelle Studie
… quantity and quality of peri- and paraimplantary bone. For this purpose 4 of the mandible premolars (P2 and P3) were extracted from each of 2 foxhounds. 20 weeks later, each dog received 6 implants. After a subsequent healing-period of 12 weeks, the mesial fixtures were charged versus each other …
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Development of Precision 3D-Printed Medical Implants
… supporting coordinated cellular responses during bone remodelling due to branched out interconnected dendritic processes, which was supported by gene expression profiles. Interestingly, only the Ti12 alloy inhibited S. aureus bacterial adhesion without negatively affecting bone cell proliferation. …
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Immediate Versus Delayed Loading of Two Implants Supporting A Locator Retained Mandibular Overdenture. A Randomized Controlled Study.
… The objective was to evaluate implant bone remodelling using radiographic bone level changes (RBL) as the variable, from baseline to six months, between the test and the control groups. The secondary objectives included (1) evaluation of implant survival, (2) nature and frequency of …
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Mapping of the binding surface between EPHA5 and antagonist peptide by NMR spectroscopy
… human diseases, such as neuron regeneration, bone remodelling diseases, and cancer. A diverse spectrum of peptides that act as antagonists of Eph-ephrin with differential selectivity has previously been identified. One of these peptides, called WDC, is attractive because it has been found to …
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Characterising the role of Valosin Containing Protein (VCP) in autophagy and cell differentiation.
… body myopathy with Paget disease of the bone and frontotemporal dementia (IBMPFD). VCP plays a key role in the ubiquitin-proteasome dependent protein degradation although mutations in VCP seem to result in a late stage autophagy defect. Osteoclast precursors containing VCP mutations are …
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Morphometric study of long bones histology
… of qualitative and quantitative analysis of long bone histology has demonstrated its usefulness in forensic human identification, including age-at-death estimation, human and non-human determination and sex determination. The establishment of an individual biological profile from the measurement …
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Comparison of the long bone microstructure of two southern African marine birds, the Cape gannet (Morus capensis) and the African penguin (Spheniscus demersus) with respect to their aquatic adaptations
… only its forelimbs. In this study, the long bones of ten penguins and nine gannets were compared in terms of microanatomy and histology with respect to ontogenetic stage (hatchlings, juveniles and adults) and locomotion. Micronatomical and histological findings of the fore-limbs and hind …
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Early Osteoarthritis: A multi-scale structural and mechanical investigation
… cartilage, calcified cartilage, and subchondral bone during the early stages of the development of the disease osteoarthritis (OA). The bovine patella was first validated as a model for intact human cartilage. The bovine patella exhibited proliferative and progressive degenerative changes that …
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Numerical simulation of implant-bone interaction following cementless joint replacement
… bond between the prosthesis and the surrounding bone remains a considerable problem. As a result, cementless implants have been developed. These components rely on the ingrowth of bone into a porous coating, which covers a portion of the component surface, to achieve the required mechanical …
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Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… nerve fibres. While several studies suggest the bone-catabolic nature of noradrenergic innervation in decreasing osteoblast activity and promoting osteoclastogenesis, there is little known on the development and function of skeletal cholinergic innervation. Therefore, the first goal of my …
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Δυναμική ταξινόμηση των μορφών της νόσου του Paget των οστών και η θεραπευτική αντιμετώπισή τους
… the traditional radiological phases of bone turnover or remodelling: that is, the osteolytic phase, the mixed phase, and the osteoblastic phase. Normal or diminished bone scan activity in the osteoblastic phase indicates diminished bone turnover which we distinguish as the osteosclerotic …