Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"bone morphogenic protein"”.
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Effects of early nutrition on the wnt and bone morphogenic protein pathways in the developing intestine
Infant formula is consumed by the majority of infants in the United States for at least part of the first year of life. Infant formula lacks many of the bioactive compounds that are naturally occurring in breast milk. Because of this, there has been an increased interest by the companies that …
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THE OUTCOME OF MAXILLARY SINUS FLOOR AUGMENTATION WITH RECOMBINANT HUMAN BONE MORPHOGENIC PROTEIN 2 VERSUS CONVENTIONAL SINUS GRAFTING PROCEDURES: A SYSTEMATIC REVIEW
… To study the effect of the recombinant human bone morphogenetic protein-2 (rhBMP-2) on sinus volumetric and histometric changes after sinus floor augmentation compared to a conventional approach utilizing other bone grafting materials, such as autografts, allografts, and xenografts. Materials …
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O-linked N-acetylglucosamine in differentiation and gene expression of mouse and human pluripotent stem cells
… or threonine residues (O-GlcNAcylation) of proteins has only recently been characterized and its overall role in cell signalling remains elusive to date. Recent studies suggest an essential role of O-GlcNAcylation on the viability and pluripotency of mouse and human embryonic stem (ES) …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
… epithelial phenotype is limited but include the bone morphogenic protein family of ligands, the epithelial splicing regulatory proteins, and the mir200 micro-RNAs. However, transcription factors which suppress EMT remain surprisingly elusive. In pursuit of identifying such a factor we searched …
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Growth Differentiation Factor 5 is a Paracrine Regulator of Sarcopenic Obesity
… Gdf5, has been recognized as playing a part in Bone Morphogenic Protein signaling to activate protein synthesis and deactivate protein degradation via SMAD 1/5/8 and SMAD 4 complex. Using RNA sequencing, Gdf5 was identified as being significantly upregulated in SO mice. Purpose: To determine the …
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EFFECTS OF OSTEOARTHRITIS AND INFLAMMATION ON MENISCUS CELL RESPONSE TO OSTEOGENIC PROTEIN 1 (OP1)
… project was to determine the response to the Bone Morphogenic Protein (BMP) family member, Osteogenic Protein 1 (OP1/BMP7) in meniscus cells. We have focused on the meniscus, because this tissue is highly susceptable to injuries which often fail to heal and lead to osteoarthritis (OA). OA is …
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Characterization and comparison of cell frequency, growth, and multipotential differentiation of adult mesenchymal stromal cells derived from equine bone marrow and adipose tissue
Equine bone marrow-derived mesenchymal stromal cells (MSCs) and adipose tissue-derived stromal cells (ASCs) were compared for frequency within their respective tissues, cell doubling characteristics and differentiation multipotential in culture based on histochemical staining and compositional …
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Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
… and we created an inducible RANK (iRANK) fusion protein which could be activated by a small molecule chemical inducer of dimerization (CID). This fusion protein was introduced into a macrophage cell line, and the resulting RAW264.7+iRANK cells were characterized using in vitro assays. In the …
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… Mutations in BMPR2, which encodes the type-II bone morphogenic protein (BMP) receptor BMPR-II, explain the majority of heritable PAH. BMPR-II forms a signalling complex, with ALK1 and endoglin, specific to endothelial cells which maintains vascular quiescence. BMP9 and BMP10 are the high …
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Analysis of the biochemical mechanisms of heterotopic ossification following musculoskeletal trauma
… Heterotopic ossification is the formation of bone in the soft tissues of the body. It is an increasingly prevalent complication following certain fractures and major orthopedic surgeries. It leads to many complications, including swelling, redness, pain, and disability due to limited range of …
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Characterisation of BMP Processing and Signalling in Adipocytes
… to obesity and related cardiovascular diseases. Bone morphogenic protein (BMP) 8B, part of the Transforming Growth Factor-β (TGF-β) superfamily, is key in regulating energy balance via activating brown adipose tissue (BAT) thermogenesis, presenting a potential target for obesity treatment. …
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Osteogenic Scaffolds for Enhanced Graft-Bone Integration in Ligament Tissue Engineering
… tissue grafts (e.g., hamstring tendon) to native bone is slow and risks graft pullout. To circumvent these limitations, tissue engineering seeks to fabricate suitable biomaterials that could replace the entire ACL, stimulate regeneration of the ligament tissue, and integrate with host bone tissue. …
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Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
… cancer cell lines – potential implications for bone preferential metastasis to bone Safaa Salman Mezban AL-Thamiree Abstract Many epidemiological studies indicate that diets rich in phytoestrogens (PE), especially soy and grain products, may be associated with a lower risk of some steroid …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
… the landmark discovery of the causative role of bone morphogenetic protein receptor type 2 (BMPR2) mutations shed new light on the pathogenesis of PAH. Since then, several genes have been discovered, which now account for around 25% of cases with the clinical diagnosis of idiopathic PAH (IPAH). …
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Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… nerve fibres. While several studies suggest the bone-catabolic nature of noradrenergic innervation in decreasing osteoblast activity and promoting osteoclastogenesis, there is little known on the development and function of skeletal cholinergic innervation. Therefore, the first goal of my …
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hyaluronic acid networks in wound healing
… were investigated: digit amputation and femoral bone fracture. Using single-cell transcriptomics, major fibroblast subtypes were identified during wound healing that synthesize key ECM components, namely hyaluronic acid (HA) and associated proteins. In digits, these ECM networks were upregulated …