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Showing 1 to 20 of 29 for “"bone morphogenetic proteins"”.

  1. Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension

    Hodgson, JoshuaUniversity of Cambridge2019

    … Mutations in BMPR2, which encodes the type-II bone morphogenic protein (BMP) receptor BMPR-II, explain the majority of heritable PAH. BMPR-II forms a signalling complex, with ALK1 and endoglin, specific to endothelial cells which maintains vascular quiescence. BMP9 and BMP10 are the high …

    cambridge Repository record

  2. Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins

    Yong, Tseh-HwanMassachusetts Institute of Technology2005

    Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems of limited availability and surgical morbidity. The use of allografts obtained …

    mit Repository record

  3. Die osteoinduktive Potenz verschiedener gentechnisch modifizierter Bone Morphogenetic Proteins : Eine vergleichende Untersuchung im Rattenmodell

    Depprich, RitaUniversität Würzburg

    … BMP-Wildtypen und gentechnisch modifizierte Bone Morphogenetic Proteins in vivo im Kalottentrepanationsdefekt bei adulten Ratten hinsichtlich ihrer osteogenen Potenz untersucht. Für alle Proteine wurde ein equiner Kollagen-Träger verwendet. Sowohl quantitativ als auch qualitativ die beste …

    wurz-thes Repository record

  4. Bone morphogenetic proteins (BMPs): new modulators of the follicle stimulating hormone (FSH) synthesis and release

    Faure, Marie-OdileThe University of Edinburgh2006

    … Other molecules of the TGF -13 superfamily, the Bone Morphogenetic Proteins (BMPs) have recently been involved for their action in reproduction at ovary level. Whether BMPs act at pituitary level and participate with other factors to regulate FSH production in females is not elucidated. In order …

    edinburgh Repository record

  5. The role of bone morphogenetic protein signalling in the control of skin repair after wounding. Cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin.

    Lewis, Christopher J.University of Bradford2015

    Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) coordinate tissue development and postnatal remodelling by regulating proliferation, differentiation and apoptosis. However, their role in wound healing remains unclear. To study this, transgenic mice overexpressing Smad1 (K14-caSmad1) …

    bradford Repository record

  6. Role of oocyte-secreted factors in prevention of cumulus cell apoptosis and enhancement of oocyte developmental competence.

    Hussein, Tamer2006

    … means the nature of the paracrine network of bone morphogenetic proteins (BMPs) and their binding proteins involved in the regulation of cumulus cell apoptosis. OSFs, in particular BMP- 15 and BMP-6, but not growth differentiation factor 9 (GDF-9), reduced apoptosis of cumulus cells by …

    adelaide Repository record

  7. Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells

    Li, Qiao,S. M.Massachusetts Institute of Technology.Massachusetts Institute of Technology2019

    … (HS)-binding growth factors, such as Wnt, bone morphogenetic proteins (BMP), and fibroblast growth factor (FGF), critically regulate cell fate decisions of ES cells. Here, we showed that HS-deficient derived from hESCs have impaired ability to differentiate into Brachyury-positive …

    mit Repository record

  8. Probing early human embryonic development to characterize BMP signaling stimulators

    Franck, OleChristian-Albrechts-Universität zu Kiel

    Bone morphogenetic proteins (BMPs) sind sowohl in der Embryonalentwicklung als auch im adulten Organismus von entscheidender Bedeutung. Da ein fehlregulierter Signalweg mit zahlreichen chronischen und schwerwiegenden Krankheiten assoziiert ist, stellt dessen Modulierung einen vielversprechenden …

    cau-kiel Repository record

  9. Retrospektive Studie über die Ergebnisse nach Implantation von autolysiertem, Antigen-extrahiertem, allogenem Knochen

    Schneider, Volkmar Peter JosefUniversität Würzburg

    Im Rahmen der von der Datenbank bone97 erfassten Zeitraums dieser Studie wurde an der Klinik und Poliklinik für Mund-, Kiefer-, Gesichtschirurgie der Universität Würzburg zwischen März 1990 und März 2002 in 1073 Fällen bei 794 Patienten (421 männlich und 373 weiblich) autolysierter, Antigen …

    wurz-thes Repository record

  10. THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS

    Singbrant, SofieDepartment of Molecular Medicine and Gene Therapy, Lund University2009

    … the role of two important regulatory candidates, Bone Morphogenetic Proteins (BMP) and Endoglin in adult hematopoiesis. Several publications have described the importance of BMP signaling in specification of hematopoietic tissue in developing embryos. In Article I and II, we investigate the full …

    lund Repository record

  11. Composite gelatin delivery system for bone regeneration

    Hager, Elizabeth A. (Elizabeth Ann)Massachusetts Institute of Technology2005

    … to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery system, designed to regenerate bone, holds much promise as an alternative to bone grafts. The chemical properties of gelatin were examined through zeta potential …

    mit Repository record

  12. The Role of Bone Morphogenetic Protein (BMP) Signalling in Lung Cancer and Lung Regeneration

    Gilbert, Jennifer L.National University of Ireland Maynooth2009

    Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta (TGFβ) super-family of signalling molecules. BMPs play crucial roles in developing and adult tissues during processes including proliferation, differentiation, apoptosis and epithelial-mesenchymal transition …

    maynooth Repository record

  13. Body Size Regulation via BMP Signaling in <i>Caenorhabditis elegans</i>

    Madaan, UdayThe Graduate School and University Center of The City University of New York2017

    … size. In Caenorhabditis elegans, a homolog of Bone Morphogenetic Proteins (BMP) is a major regulator of body size; functional loss of DBL-1 leads to a small body size. Due to a drastic change in body size in dbl-1 mutants, we have the advantage of studying body size as a monogenic trait and we …

    cuny-grad Repository record

  14. Spatio-temporal investigation and quantitative analysis of the BMP signaling pathway

    Schul, DanielaUniversität Würzburg

    Bone Morphogenetic Proteins (BMPs) are key regulators for a lot of diverse cellular processes. During embryonic development these proteins act as morphogens and play a crucial role particularly in organogenesis. BMPs have a direct impact on distinct cellular fates by means of …

    wurz-thes Repository record

  15. Expression und Isolierung des BMP-bindenden Proteins Ep45

    Mai, NikolaUniversität Würzburg

    Die BMPs (Bone morphogenetic proteins) sind Zytokine, die in fast allen Tieren exprimiert werden und zur TGF-β Superfamilie gehören. Sie spielen eine wichtige Rolle in der Knochenentwicklung, unter anderem auf Grund ihrer Fähigkeit, die Neubildung von Knochen auszulösen. Eine weitere Aufgabe der …

    wurz-thes Repository record

  16. The Quantitative Assessment of Osteoinductivity of Human Demineralized Bone Matrix and cDNA Array Analysis of Osteogenic Differentiation in Human Periosteal Cells

    Honsawek, Sittisak2019

    <p>Demineralized bone matrix (DBM) has been extensively utilized in orthopeadic, periodontal, and maxillofacial applications. DBM comprises bone morphogenetic proteins (BMPs) that are essential regulators for endochondral bone formation. The current study was undertaken to establish the …

    odu Repository record

  17. BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality

    Danesh, Shahab Malekpour2010

    … signals for pancreatic development. Various bone morphogenetic proteins (Bmps) and Bmp receptors (Bmprs) are expressed in the pancreas and in the tissues that flank the pancreatic bud during pancreatic development. Bmp7, BmpR1a, and BmpRII are expressed in the pancreatic endoderm during …

    utswmed Repository record

  18. Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment

    Bosemark, PerDepartment of Orthopaedics, Lund University2014

    … but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in …

    lund Repository record

  19. Analysis of the Function of Megf7 During Development

    Johnson, Eric Boyd2010

    Lrp4/Megf7, a member of the low-density lipoprotein receptor gene family, is a major regulator of tissue patterning during embryonic development. Prior to this work, the function Megf7 had largely been unknown. Eight distinct mutations in Megf7 were introduced into mice in order to facilitate a …

    utswmed Repository record

  20. Healing of Bone Fracture in Type 1 Diabetic Rat Models: a Potential Gene Therapy Using Bone Morphogenetic Protein

    Guo, QidongUniversity of Dundee2015

    … the impaired healing procedure after fracture. Bone morphogenetic proteins are well-known for their osteoinductive functions. BMP-6, which is a newly-discovered member to the BMP family, has been reported to show potent bone-forming effects and take active part in glucose metabolism. Although …

    dundee Repository record

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