Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"bone morphogenetic protein-2"”.
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Klonierung, Expression und Charakterisierung von Mutanten des Bone Morphogenetic Protein-2
Das Zytokin Bone Morphogenetic Protein-2 (BMP-2) gehört als Mitglied der Transforming Growth Factor ß-Superfamilie zu einer großen Gruppe eng verwandter Wachstums- und Differenzierungsfaktoren. Es spielt eine entscheidende Rolle bei Bildung und Regeneration von Knorpel und Knochen und während …
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Die Wiederherstellung der Unterkieferkontinuität mittels rhBMP-2 (Recombinant Human Bone Morphogenetic Protein-2) nach ausgedehnten Resektionen im Minischwein
… kollagenen Träger (ICBM, insoluble collagenous bone matrix) rekonstruiert. Bei der zweiten Hälfte wurde dieser Träger zunächst in eine Muskeltasche des M. latissimus dorsi heterotop implantiert. Der neugebildete Knochen wurde nach acht Wochen zur Rekonstruktion in den Unterkiefer transplantiert. …
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Differentielle Genexpression bei der Membranösen Glomerulonephritis und die Rolle des 'bone morphogenetic protein 2' für die Funktion des Podozyten
… einer Schädigung des Podozyten mit nachfolgender Proteinurie kommt. Unklar ist, welche zellulären Mechanismen zu der anhaltenden Funktionsstörung des Podozyten führen. Die Ergebnisse der vorliegenden Arbeit lassen sich wie folgt zusammenfassen:<br>Mit Hilfe von cDNA-Expressions-Analysen konnte die …
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Inflammatory and Immune Effects of Intra-Articular Mesenchymal Stem Cells in Horses
… injection of autologous, genetically modified (bone morphogenetic protein 2) autologous, allogeneic, and xenogeneic bone marrow-derived mesenchymal stem cells (MSC) in horses. The study group consisted of 6 five-year-old Thoroughbred mares, free of musculoskeletal disease in the fetlocks. The 4 …
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THE OUTCOME OF MAXILLARY SINUS FLOOR AUGMENTATION WITH RECOMBINANT HUMAN BONE MORPHOGENIC PROTEIN 2 VERSUS CONVENTIONAL SINUS GRAFTING PROCEDURES: A SYSTEMATIC REVIEW
… To study the effect of the recombinant human bone morphogenetic protein-2 (rhBMP-2) on sinus volumetric and histometric changes after sinus floor augmentation compared to a conventional approach utilizing other bone grafting materials, such as autografts, allografts, and xenografts. Materials …
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Long-term osteointegration of BMP-2 eluting hydroxyapatite scaffolds for bone tissue engineering
… and tumor resections can result in discontinuity bone defects, which are typically treated through bone grafting. Potential limitations, such as donor site morbidity, make the development of synthetic implants with similar success to current techniques an attractive alternative for the repair of …
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Identification of transcriptional mechanisms downstream of nf1 gene defeciency in malignant peripheral nerve sheath tumors
… in an inoperable location. Neurofibromin, the protein coded by the Nf1 gene, functions as a GTPase activating protein (GAP) whose mutation leads to constitutive activation of RAS and mitogen-activated protein kinase (MAPK) signaling in NF1 patientsf tumors. However, therapeutic targeting of RAS …
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Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions
… focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer (LbL) deposition platform was used to fabricate conformal, tunable, micron scale …
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Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
Bone has the innate ability to heal, but on occasion defects surpass a critical size capable of spontaneously healing. These critically-sized bone defects pose significant challenges for reforming bone continuity and often require surgical intervention to facilitate bone regeneration. Recently, …
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The role of DEL1 in chondrocyte expansion and mechanotransduction: an investigative study
… The induction of Sox9 expression using Bone Morphogenetic Protein 2 and Twist knockdown using RNAi enhanced the expression of DEL1, suggesting DEL1 regulation of dedifferentiation by a feedback signal previously unreported.
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Adeno-Associated Virus-Based Gene Delivery Approaches for Tissue Engineering
… Optogenetic tools based on light-sensitive proteins offer an exquisite option for fine-tuning expression levels with minimal interference and at low cost. Adeno-associated virus (AAV) is employed as the candidate gene delivery vehicle due to its ability to infect many cell types and good …
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Synthetic Hydrogel Delivery of Growth Factors and Demineralized Bone Matrix for Bone Augmentation
… delivery of growth factors and demineralized bone matrix (DBM) for bone augmentation. Our motivation rests on observed weaknesses of current clinical approaches to bone augmentation, which synthetic hydrogels hope to overcome based on non-invasive application, contouring, tunability, and drug …
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Calcium Phosphate Nanoparticle Synthesis and Manufacture using Microwave Processing for Biomedical Applications
… are known to be major constituents of mammalian bone and synthetic CaPs have been shown to be bioactive in vitro and in vivo. They are one of the most versatile biomaterials for orthopedic applications and have been shown to be effective scaffolds for bone regeneration and as gene delivery …
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Characterization of a Novel Nuclear Variant of Bmp2 and Coordinate Regulation of Col11a2 and Col27a1 by the Transcription Factor Lc-Maf
… OF A NOVEL NUCLEAR VARIANT OF BMP2<br /><br />Bone morphogenetic protein 2 (Bmp2) is a signaling protein that was first detected by its ability to induce cartilage and bone formation. It has since been implicated in broad variety of developmental, patterning, and disease processes. To date, …
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Layer-by-Layer Systems for Craniomaxillofacial Bone Repair
The treatment of craniomaxillofacial bone defects with drug-eluting synthetic implants is a promising treatment currently being investigated. It is becoming increasingly recognized that release rate of growth factor proteins signaling bone regeneration and vascularization is a key optimization …
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Functional Self-Assembled Poly (L-Lactide) Nanoparticles For Targeted Delivery of Bioactive Agents
… NPs an ideal carrier for applications such as bone tissue regeneration and cancer therapy. Bone diseases and cancer affect millions of people each year, and current treatments present limitations due to costs, side effects, and lack of compatibility. This work will focus on the applications of …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… between cartilage and the underlying subchondral bone, linking the pathogenesis/regeneration of both tissues. Thus, this thesis seeks to develop hydrogel composites as growth factor and cell delivery vehicles to study the regeneration of osteochondral tissue. First, we investigated the release of …
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Βιοχημικοί και ιστοπαθολογικοί δείκτες εκτίμησης αποτελεσματικότητας σύγχρονων θεραπευτικών προσεγγίσεων οστεοπόρωσης
… ανοσοϊστοχημική χρώση των μορίων Bone Morphogenetic Protein-2 (BMP-2) και Fas (παράγοντας οστεοκλαστικής απόπτωσης) σε τομές σε πλαστικό, καθώς και ανοσοαποτύπωση κατά Western των αυτών πρωτεϊνών. Γενικά, όλες οι μέθοδοι που εφαρμόστηκαν, έδειξαν να ακολουθούν όλες τις μεταβολές …
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Mechanical Evaluation of Mandibular Defects Restored with rhBMP-2: A Finite Element Model
… The utilization of recombinant human Bone Morphogenetic Protein-2 (rh- BMP2) to form new bone has been shown to be a promising alternative to autogenous bone grafts. Understanding the biomechanical properties of rhBMP-2 restored mandibular defects would provide useful knowledge in the …
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Characterization of skeletal stem cells derived from different musculoskeletal locations
Bone is a renewable tissue that is constantly remodeled throughout life and has the ability to self-repair following an injury or disease-related bone loss. As the appropriate recruitment of skeletal stem cells (SSCs)/progenitors is required for successful bone homeostasis and repair, targeting …
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