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Showing 1 to 20 of 35 for “"bone morphogenetic protein (BMP)"”.

  1. Bone morphogenetic protein (BMP-7) και μοριακά δίκτυα δυνητικών stem κυττάρων στον νεφρό

    Τρίγκα, Κωνσταντίνα2011

    Η BMP-7 αποτελεί μόριο κλειδί κατά την εμβρυογένεση στον νεφρό, ενώ μετέπειτα, θεωρείται νεφροπροστατευτικός παράγων. Ο νεφρός χαρακτηρίζεται από μία μοναδική πλαστικότητα μεταξύ επιθηλιακών και μεσεγχυματικών κυττάρων. Κατά την ανάπτυξη του Νεφρού, το επιθήλιο του νεφρώνα δημιουργείται μέσω της …

    patras-thes Repository record

  2. The Role of Bone Morphogenetic Protein (BMP) Signalling in Lung Cancer and Lung Regeneration

    Gilbert, Jennifer L.National University of Ireland Maynooth2009

    Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta (TGFβ) super-family of signalling molecules. BMPs play crucial roles in developing and adult tissues during processes including proliferation, differentiation, apoptosis and epithelial-mesenchymal transition …

    maynooth Repository record

  3. The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway

    Patel, NeetaKing's College London2012

    … is principally transcriptional, where the Bone Morphogenetic Protein (BMP) pathway has been shown to be a major network governing hepcidin expression. The current study utilised the HPX mouse model to identify potential regulators of hepcidin that are produced locally in liver with a focus …

    kings Repository record

  4. Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells

    Nganwuchu, Chinyere C.University of Bradford2025

    … being a loss of characteristic mutation in the BMPR2 gene, a member of the TGFβ Superfamily. In this study, it was hypothesised that these green tea catechin compounds might inhibit TGFβ signalling while promoting BMP signalling. This study demonstrates that these green tea catechin compounds …

    bradford Repository record

  5. Identification of a Novel Role of BMP Signaling in Enteric Neural Crest Colonization of the Zebrafish Enteric Nervous System

    Moore, Joshua AlanRice University2023

    … I identified a time-dependent role for bone morphogenetic protein (BMP) in the maintenance of Phox2bb+ enteric progenitor numbers and/or time of differentiation of the progenitor pool. In support of our in silico transcriptomic analysis, I identified the expression of a novel ENS …

    rice Repository record

  6. QUANTITATIVE MODELING OF SCALING OF PATTERNS AND RECEPTOR SIGNALING IN MORPHOGENESIS

    Karim, Md Shahriar

    … In addition, details of the signal, such as the Bone Morphogenetic Protein (BMP) signal, that transmit patterning information to a group of homogenous cells to differentiate is not well understood. Determining how developmental processes ensure robust patterning in the presence of perturbations, …

    purdue-thes Repository record

  7. Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension

    Theilmann, Anne2019

    … is strongly linked to heterozygous mutations in BMPR2, the gene encoding the bone morphogenetic protein (BMP) type II receptor (BMPR-II). The endothelial-selective BMPR-II ligand, BMP9, has been shown to reverse disease in animal models of PAH and suppress the proliferation of healthy endothelial …

    queens Repository record

  8. Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension

    Fagbola, Emmanuel2023

    … (TGN) and plasma membrane (PM) is vital for protein secretion and growth factor signaling, which involves recycling and PM localization of cell surface receptors. These processes depend on the cytoskeleton and the presence of phosphoinositide (PI) species in specific intracellular …

    queens Repository record

  9. Developing a Caenorhabditis elegans Model for Marfan Syndrome

    Fotopoulos, Pauline2019

    … gene, which encodes an extracellular matrix glycoprotein, and is required for proper cardiac and skeletal development and for sequestration of TGFβ (transforming growth factor beta) and BMP (bone morphogenetic protein) within the extracellular matrix (ECM). The primary objective of this study was …

    vcu Repository record

  10. Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells

    Molloy, Emer LouiseNational University of Ireland Maynooth2008

    Bone morphogenetic protein (BMP) signalling is essential for correct lung development where it mediates lung branching morphogenesis. In the adult lung, the BMP pathway is activated during airway inflammation. However, a role for activated BMP signalling has not yet been elucidated. The aims of …

    maynooth Repository record

  11. Investigating the coordination of germline stem cell fate by ecdysone signaling and BMP signaling in the Drosophila ovary

    Warren, Alexandria IvanaEast Carolina University2025

    … convergence is achieved. Ecdysone signaling and Bone Morphogenetic Protein (BMP) signaling are well-known signals that promote GSC self-renewal. Over-expression of Ecdysone Receptor (EcR), knock-down of bag of marbles (bam), or over-expression of constitutively active thickveins (tkv) in all germ …

    ecu Repository record

  12. KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS

    R. CuttanoUniversità degli Studi di Milano2016

    … vivo. KLF4 promotes an endogenous production of bone morphogenetic protein 6 (BMP6) in ECs that, in turn, activates the transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signalling pathway. KLF4 transcriptional activity and KLF4-dependent TGF-β/BMP pathway activation are …

    milano Repository record

  13. A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells

    Lim, Daniel A

    … cells lie adjacent to the SVZ. I show that the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells and that SVZ cells express BMP s as well as their receptors. In vitro, BMP signaling potently inhibited neurogenesis. Conversely, Noggin protein in vitro promoted …

    rockefeller Repository record

  14. Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.

    Mardaryev, Andrei N.University of Bradford2010

    Bone morphogenetic protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of …

    bradford Repository record

  15. SOSTDC1: A BMP/Wnt Dual Antagonist in Breast and Renal Cancers

    Blish, KimberlyWake Forest University2009

    ABSTRACT Blish, Kimberly Rose SOSTDC1: A BMP/WNT DUAL ANTAGONIST IN BREAST AND RENAL CANCERS Dissertation under the direction of Suzy V. Torti, Ph.D., Associate Professor of Biochemistry The bone morphogenetic protein (BMP) pathway and the Wnt pathway are signaling networks associated with …

    wfu Repository record

  16. Novel Oncogenic Drivers in Pediatric Gliomagenesis

    Diaz, Alexander K.2016

    … a receptor serine-threonine kinase involved in bone morphogenetic protein (BMP) signaling. These alterations led to gain-of-function as evidenced by increased phosphorylation of downstream targets in primary astrocytes and zebrafish embryo ventralization. Whole-genome sequencing and RNASeq …

    tenn-hsc Repository record

  17. The use of small molecules to illuminate vascular development

    Goi, MichelaGraduate Studies2017

    … molecule inhibitors, I found that both Vegf and Bone morphogenetic protein (Bmp) signaling drive the growth and patterning of this plexus. A genetic mutant with overgrowth of the intestinal vasculature follows similar growth cues, but development is faster and unrestricted. Finally, I have …

    calgary Repository record

  18. Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?

    Chen, CiviaUniversity of Cambridge2022

    … genes involved in integrin signalling and with bone morphogenetic protein (BMP) activation. I showed that recapitulating the lesion environment by exposing cultured OPCs to vitronectin and BMP4 is sufficient to induce a SC fate within one week of induction. OPC-derived SCs morphologically and …

    cambridge Repository record

  19. Portal hypertension in cirrhosis and its associated pulmonary vascular disorders

    Owen, NicolaUniversity of Cambridge2021

    … oxygen saturation. Among cirrhotics, circulating bone morphogenetic protein (BMP) 9 and 10 levels were normal in compensated individuals but undetectable in those with decompensated disease. This loss of BMP9/10 suggests these ligands have a significant role in maintaining endothelial homeostasis …

    cambridge Repository record

  20. Fate, Phases, and Form in Vertebrate Organ Morphogenesis-Uncovering a Role of Morphogenesis at the Supracellular Scale

    Yang, Sichen

    … and solid hemispheric core compartment, whereas bone morphogenetic protein (BMP) promotes a surrounding fluid and active contractile margin compartment. Through their geometric arrangement, the two compartments are mechanically primed to break tissue symmetry and result in follicle budding. We …

    rockefeller Repository record

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