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Showing 1 to 20 of 25 for “"bone metastasis"”.

  1. Bone Metastasis from Primary Hepatocellular Carcinoma: Chararcteristics of Soft Tissue Formation

    김, 상원2011

    간세포암에 의한 골전이는 소수의 문헌을 통해 연부조직을 형성하여 골융해를 유발하는 것으로 알려져 있다. 여타 다른 원발성 암에 의한 골전이와 마찬가지로, 간암에 의한 골전이의 주 치료법은 방사선치료이나 치료 후 증세 완화의 정도는 다른 골전이보다 떨어지는 경향이 있다. 본 문헌에서는 1994년 10월부터 2004년 12월까지 아주대병원 방사선종양학과로 의뢰된 간세포암에 의한 골전이를 진단받은 환자들의 병력 기록 및 영상학적 검사 결과를 검토하여 간세포암에 의한 골전이의 성상을 규명하고 그 특징이 방사선치료에 미치는 영향에 대해 …

    ajou Repository record

  2. MICRORNAs AS PREDICTIVE AND THERAPEUTIC TOOLS IN PROSTATE CANCER AND BONE METASTASIS

    CANNISTRACI, ALESSIOUniversità degli studi di Catania2013

    Il carcinoma della prostata è una delle malattie più comuni ed è nell uomo, la principale causa di morte dovuta a patologie neoplastiche. Nonostante i significativi progressi nella diagnosi e nel trattamento dei tumori precoci, la validazione di nuovi biomarcatori, in grado di distinguere tra …

    catania Repository record

  3. Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis

    Al-thamiree, Safaa Salman Mezban2019

    … cancer cell lines – potential implications for bone preferential metastasis to bone Safaa Salman Mezban AL-Thamiree Abstract Many epidemiological studies indicate that diets rich in phytoestrogens (PE), especially soy and grain products, may be associated with a lower risk of some steroid …

    plymouth Repository record

  4. Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model

    Salazar-Arcila, CarolinaGraduate Studies2013

    Development of breast cancer-induced bone loss depends on the activation of osteoclasts by tumor-derived factors that promote osteoclastogenesis and osteolysis. The PI3K pathway is activated by several of these factors, in particular CSF-1. Given the ability of PI3K signaling to promote osteoclast …

    calgary Repository record

  5. Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment

    Lopetegui Gonzalez, IsbelGraduate Studies2026

    … and is often associated with osteolytic bone metastasis, characterized by bone destruction. There is growing evidence for a role of autocrine prolactin (PRL) signalling in breast cancer progression, as well as for a role of prolactin in breast cancer-associated bone metastasis. The role …

    calgary Repository record

  6. Regulation of Breast Cancer Cells’ Bone-Metastatic Potential by Mechanically Stimulated Osteocytes

    Ma, Yu-Heng Vivian2019

    Bone metastasis, the migration of cancers to the bone, occurs in 65-75% of patients with advanced breast cancer and significantly increases patients’ morbidity and mortality. The bone-metastatic cancer cells interact with cells in the bone to disrupt the bone remodeling balance, causing reduced …

    toronto-retro Repository record

  7. 골경화성 골전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성

    윤, 석호2012

    Bone metastasis is an important factor for treatment and prognosis of breast cancer patients. Whole body bone scintigraphy can be used to evaluated bone metastases and also F-18 FDG PET/CT seems to exhibit high specificity and accuracy to detect skeletal metastases. However there is the limitation …

    ajou Repository record

  8. Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis

    Wu, KeruiWake Forest University2017

    Metastasis is the principle cause of the deaths among breast cancer patients. Brain is one of the major sites of metastasis in breast cancer; however, the pathological mechanism is poorly understood. One of critical steps of brain metastasis is the breaching of the BBB and this process is …

    wfu Repository record

  9. Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis

    Jin, Jung-Kang2014

    … overexpression of talins promote prostate cancer metastasis, understanding the mechanism by which talins activate integrins will better elucidate their roles in Prostate cancer metastasis. Phosphorylation of talins on serine 425 has been associated with β1 integrin functions. Work in this …

    uthsc Repository record

  10. Investigation of the role of Col4a1 and Itga11 in enzalutamide resistance of prostate cancer cells

    Ciszek, AleksandraThe University of Edinburgh2022

    … Prostate Cancer (CRPC). CRPC is very likely to metastasise to bone, which worsens morbidity and mortality. Metastatic CRPC (mCRPC) is currently incurable and accounts for over 90% of PCa-related deaths. Tumour-associated macrophages (TAMs) can promote ADT resistance in bone metastasis, but the …

    edinburgh Repository record

  11. Bisphosphonate-related osteonecrosis of the jaw

    Thumbigere Math, Vivek2013

    … patients with osteoporosis, Paget’s disease, bone metastasis, and multiple myeloma. BP’s anti-resorptive activity substantially reduce fracture risk by 40%-70% in osteoporosis patients, and improve quality of life in cancer patients by preventing skeletal complications. However, prolonged BP …

    umn Repository record

  12. Angiomotin Is A Novel Cadherin-11 Interacting Protein That Mediates Migration In Prostate Cancer Cells

    Ortiz, Angelica2014

    … States, has the proclivity to metastasize to bone resulting in sclerotic lesions. These cancer induced bone growths cause bone pain and fractures. Therefore, understanding the molecular mechanisms contributing to PCa bone metastasis is required in order to find better prognostic tools and …

    uthsc Repository record

  13. Osteonecrosis of the jaw in association to bisphosphonates

    Mattos, Ana Carolina LopesBoston University2008

    … has become more widespread for the treatment of bone metastasis, multiple myeloma, osteoporosis, Paget's disease and other bone malignancies. Osteonecrosis of the jaw (ONJ) has been recently recognized as a possible complication of the use of bisphosphonate therapy. This study includes a review …

    bu Repository record

  14. Glycosylation of Prostate Cancer Cell Lines and Glycosyltransferase Characterization and Inhibition

    Gao, Yin2013

    … aggressive prostate cancer cells derived from bone metastasis (PC-3). The expression and activity of sialyltransferase ST3Gal-I, responsible for the synthesis of sialyl-T antigens, were up-regulated in PC-3 cells, providing a mechanism for sialyl-T expression. Forced down-regulation of ST3Gal-I …

    queens Repository record

  15. The Role of Mir-34A In Inhibition of Prostate Tumor Growth In The Bone and Induction of Autophagy

    Gaur, Sanchaika2015

    … United States, with most deaths occurring from bone metastasis. Several new therapies have been FDA approved for bone-metastatic PCa, but patient survival has only marginally improved due to therapy resistance, which often arises from constitutive activation of compensatory signaling pathways. …

    uthsc Repository record

  16. Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases

    Kunihiro, AndrewThe University of Arizona.2019

    Osteoclast-mediated bone resorptive disorders, including post-menopausal osteoporosis, age-related bone loss, rheumatoid arthritis, and osteolytic bone metastases, affect over 55 million Americans each year. Breast cancer bone metastases, the model of bone resorptive disorders to be used here, …

    arizona-thes Repository record

  17. Investigating Human Cell Influence on the Micromechanical Environment of a 3D-Printed Bone Tissue Model

    Shangin, Edward AlexVirginia Tech2025

    … with the spread of tumors to distant sites, or metastasis, with the skeletal system being one of the most common locations for metastasis, with rates as high as 70%. Despite this, the mechanistic factors behind BC cell recruitment, infiltration, and survival in the bone niche remain …

    vt Repository record

  18. Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer

    Peramuhendige, Pushpabhani PrabhaThe University of Edinburgh2016

    … in the regulation of both osteoclastic bone resorption and breast cancer. Here I studied the role of TRAF2 and TRAF6 in breast cancer induced osteoclastogenesis and osteolysis. I observed that TRAF2, but not TRAF6, is highly expressed in a highly metastatic bone-tropic clone of the human …

    edinburgh Repository record

  19. Using Mechanical Interventions To Enhance Drug Transport To Bone Tumors

    Gelbs, Michelle2024

    <p>Bone metastasis occurs when cancer cells spread from a primary site to a secondary location in bone. Current treatments for metastatic bone tumors typically involve systemic chemotherapy, bisphosphonates, radiotherapy, or surgery; however, due to morphological changes in the tumor …

    cuny Repository record

  20. Radiobiological mechanisms and novel imaging biomarkers in metastatic prostate cancer treated with radium-223

    Alshehri, Ali Hamad DQueen's University Belfast2021

    … to castration-resistant prostate cancer (CRPC). Bone metastases are an extremely common disease state, present in 90% of patients with metastatic CRPC (mCRPC). The use of alpha (α)-particle radionuclide emitters for the treatment of metastatic bone disease is an active area of research in …

    qu-belfast Repository record

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