Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"bone metastases"”.
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Relevance of Fgfr1 and Its Isoforms In Prostate Cancer Bone Metastases
… in enhanced tumor growth and reduction in bone volume when compared with PC3 expressing empty vector. However, only PC3 overexpressing FGFR1 b was associated with increased osteoclast parameters, suggesting that each isoform may mediate diverse biological effects (similar findings were …
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Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
… in the regulation of both osteoclastic bone resorption and breast cancer. Here I studied the role of TRAF2 and TRAF6 in breast cancer induced osteoclastogenesis and osteolysis. I observed that TRAF2, but not TRAF6, is highly expressed in a highly metastatic bone-tropic clone of the human …
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The study of the complexation of Sn(ii)-APDDMP and Sn(iv)-PEIMP, considered as potential therapeutic agents for bone metastases
Includes bibliographical references (leaves 103-104).
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Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases
Osteoclast-mediated bone resorptive disorders, including post-menopausal osteoporosis, age-related bone loss, rheumatoid arthritis, and osteolytic bone metastases, affect over 55 million Americans each year. Breast cancer bone metastases, the model of bone resorptive disorders to be used here, …
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Identificazione di bersagli terapeutici e realizzazione di tecnologie innovative in oncologia ortopedica
… approach for the adjuvant therapy of osteolytic bone metastases. Doxorubicin (DXR) is widely used in chemotherapy, although its activity is restricted by dose-dependent cardiotoxicity and marrow toxicity. However, its efficacy can be improved when specific targeting at the tumor site is obtained. …
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Treatment response using CT-based rigidity analysis in an animal model of lytic musculoskeletal lesions subjected to systemic therapy
… alone. Approximately two-thirds of patients with bone metastases will experience pain, pathological fractures, spinal cord or nerve root compression, paralysis, impaired mobility, bone marrow infiltration and hypercalcemia of malignancy. We induced bone metastases through inoculation of rat femurs …
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Radiobiological mechanisms and novel imaging biomarkers in metastatic prostate cancer treated with radium-223
… to castration-resistant prostate cancer (CRPC). Bone metastases are an extremely common disease state, present in 90% of patients with metastatic CRPC (mCRPC). The use of alpha (α)-particle radionuclide emitters for the treatment of metastatic bone disease is an active area of research in …
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Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
… is upregulated in primary prostate cancer and bone metastases. However, PDGF B, formerly thought to be the sole ligand for ?-PDGFR, is not expressed in clinical prostate cancer samples. In a study of human primary prostate carcinoma and bone metastases, we found that PDGF D and matriptase are …
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Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis
… target for brain metastasis. One the other hand, bone is the most frequently affected organ in metastatic breast cancer. Prediction and early detection of bone metastasis is particularly important for the management of breast cancer progression. We checked the secreted microRNA profiles in breast …
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Advanced Cancer Patients' Perspectives on a Video Decision Support Aid used to Enhance Goals of Care Discussions
… from an Outpatient Radiation Oncology Bone Metastases Clinic. Extended Elaboration Likelihood Model was the conceptual framework used to guide data analyses. Participants found the video scenarios made the GOC framework more personally relevant. They were able to relate their …
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A Molecular and In Vivo Investigation of Advanced Prostate Cancer: Deconstructing Ampk Activity and Developing An Improved Mouse Model
… Prostate cancer metastasizes primarily to bone, with up to 90% of men who die of prostate cancer having bone metastases upon autopsy. A major limitation in the study of advanced prostate cancer is a lack of relevant preclinical models of disease progression. Rodents are the most commonly …
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Development of positioning devices for MRI-guided high intensity focused ultrasound (HIFU) for abdominal, thyroid and brain, tumours
… arithmia, strokes, palliative pain treatment of bone metastases and brain disorders such as Parkinson’s disease, essential tremor, and neuropathic pain. These optimistic investigations have encouraged physicians and provided them new valuable tools for medical research.
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Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
Development of breast cancer-induced bone loss depends on the activation of osteoclasts by tumor-derived factors that promote osteoclastogenesis and osteolysis. The PI3K pathway is activated by several of these factors, in particular CSF-1. Given the ability of PI3K signaling to promote osteoclast …
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골경화성 골전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성
Bone metastasis is an important factor for treatment and prognosis of breast cancer patients. Whole body bone scintigraphy can be used to evaluated bone metastases and also F-18 FDG PET/CT seems to exhibit high specificity and accuracy to detect skeletal metastases. However there is the limitation …
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Étude de l’expression et du rôle du ligand du co-stimulateur inductible des cellules T (ICOSL) dans les ostéoclastes humains
When cancer cells metastasize to bone, they interact in the bone microenvironment with bone cells and immune cells present in the adjacent bone marrow. Osteoclasts, which degrade the bone matrix, express costimulatory molecules on their surface, like antigen-presenting cells, which enable them to …
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Detecting prostate cancer metastases - PET/CT and the sentinel node technique
… highly dependent on the presence or absence of metastases. The available invasive and non-invasive modalities for detecting metastases are imperfect. Positron-emission tomography fused with computed tomography (PET/CT) is a non-invasive method for detecting metastases that is presently evaluated …
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Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non-Invasive Mechanical Loading
… develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the …
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Enhancement of death receptor-mediated apoptosis in multiple myeloma cells
… of solid disseminated MM lesions that form in bone. Methods: The effects of TRAIL sensitizers and/or TRAIL treatment were investigated in both suspension cultures and in an alginate-based 3D culture model. Apoptosis was detected by assessment of nuclear morphology using Hoechst 33342/PI …
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Medication-Related osteonecrosis of the jaw in women with breast cancer. a literature review /
… those with advanced breast cancer prone to bone metastases. Bisphosphonates (BPs) and Denosumab (DNB) are key bone-modifying agents (BMAs) used to target bone metabolism, reduce metastatic risk, and enhance adjuvant therapy efficacy in early-stage breast cancer. However, the usage of these …
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Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis
… phosphorylation is required for Prostate cancer bone metastasis <em>in vivo</em>. In the metastatic PC3-MM2 cells, expression of a non-phosphorylatable mutant, talin1<sup>S425A</sup>, in talin1-silenced PC3-MM2 cells, abolished their ability to colonize in bone following intracardiac injection, …
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