Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"bone marrow-derived cells"”.
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In vitro comparison of equine tendon- and bone marrow-derived cells expanded with FGF-2 prior to culturing with tendon matrix and IGF-I
… on monolayer expansion of equine tendon- and bone marrow-derived cells prior to culture with autogenous acellular tendon matrix and insulin-like growth factor-I (IGF-I). Progenitor cells were isolated from six young adult horses, expanded in monolayers with FGF-2, and cultured with autogenous …
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Comparative osteogenesis of equine mesenchymal stem cells isolated from bone marrow, adipose tissue, and synovium
… define the osteogenic potential of equine MSCs derived from synovium, bone marrow, and adipose tissue maintained under the same culture conditions. Equine MSCs were isolated from synovium [SYN], bone marrow [BM] and adipose tissue [AD], expanded in monolayer culture for two passages, and then …
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… shown that vasculogenesis, the process by which bone marrow-derived cells are recruited to the tumor and organized to form a blood vessel network de novo, is essential for the growth of Ewing’s sarcoma. We further demonstrated that these bone marrow cells differentiate into pericytes/vascular …
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Aspects of T cell development contributing to autoimmunity.
… breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. The work presented in this thesis was aiming at unravelling some of …
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Engineered approaches to querying the microenvironment of cancer metastasis
… onto polyacrylamide coated glass slides. Cells are seeded onto these arrays and queried for their adhesion, proliferation, and marker expression using automated fluorescence microscopy in conjunction with automated cell counting and image analysis. In the first part of this thesis, this …
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Eph-mediated restriction of cerebrovascular arteriogenesis
… degradation and recruitment of circulating bone marrow-derived cells (4-6). Unlike spouting angiogenesis, which requires weeks following occlusion to develop, arteriogenesis begins as early as 24-48hrs post-stroke (7, 8) and can expeditiously enhance blood flow to ischemic regions, making it …
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The impact of cholesterol and its metabolites on the ovarian tumor microenvironment and cancer progression
… them, CYP27A1 is highly expressed in myeloid cells and oxidizes cholesterol into 27-hydroxychoelsterol (27HC), which is the most abundant oxysterol and an endogenous signaling molecule. In addition, serum 27HC concentration closely correlates to that of cholesterol. Analysis of publicly …
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The role of autophagy in protecting periodontium integrity, and lipopolysaccharide-induced osteoclast differentiation
… dependent. Autophagy may also be important for bone remodeling in the oral cavity. Two scenarios where bone remodeling is key to the physiological outcome are orthodontic tooth movement and inflammatory-induced periodontal disease. This thesis aims to investigate the hypothesis that autophagy is …
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
… the virus-host interaction is a unique group of cells called the antigen presenting cells (APC). APC play a significant role in immune response, as the receptionist, they are the first cells to detect pathogen invasion and present the antigen to the cells of the adaptive immune system for …
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Major Collateral Vessels Develop from Pre-existing Small Arteries through RAC2/NOX2 Independent Mechanisms
… arterial occlusion. Previous studies suggest bone marrow cell (BMC)-derived reactive oxygen species (ROS) produced by the Nox2 subunit of NAD(P)H oxidase plays an important role in neovascularization and recovery of hindlimb perfusion subsequent to femoral arterial occlusion; but did not …
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The Ontogeny of Antigen-Binding Cells
… to analyze the development of antigen-specific cells, the binding of a variety of antigens by cells in the fetal, neonatal, and adult mouse was compared. The fiber-binding assay was used in many of these experiments, because it provides a simple and uniform method for studying the specific …
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The Recruitment and Function of Tumor Microenvironment Components During Gastric Carcinogenesis
… been rightly paid to the behavior of transformed cells, some focus has recently shifted to the components of the soil in which tumors develop and grow, commonly referred to as the microenvironment. Here, we investigate the gastric tumor microenvironment and shed light on the role of …