Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"bone marrow transplantation"”.
-
Immune reconstitution post bone marrow transplantation
… immune reconstitution following T-cell depleted bone marrow and peripheral blood stem cell transplantation and to compare this with the recovery following autologous grafts. to document the cell surface expression of CD95 in an attempt to comment on the role played by FAS mediated apoptosis in …
-
Bone marrow transplantation in infancy and childhood
During a bone marrow transplant there is a major risk of infection either due to the specific disease or as a result of the required preconditioning. Severely neutropenic patients benefit from receiving prophylactic antimicrobial agents within a protected environment and the thesis opens with a …
-
The role of HLA-G in bone marrow transplantation
… molecule in the allogeneic hematopoietic cell transplantation setting. The percentage of HLA-G+ cells in peripheral blood of healthy donors and allo-transplanted patients was evaluated by flow cytometry. Their immunoregulatory and immunotolerogeneic properties were investigated in in vitro …
-
Leukemia and bone marrow transplantation : personal meanings and perceptions of the illness experience
… purposive sample was selected from the bone marrow transplant (BMT) directory of a North American transplant center to describe the personal meanings and perceptions of the illness experience of individuals who had been diagnosed with leukemia, and undergone BMT, and to explore and …
-
The Impact of Family Functioning on Children's Adaptation During a Parent's Bone Marrow Transplantation
Bone marrow transplant (BMT) is being used ever more widely for advanced and refractory malignancies. The family unit and individual members are profoundly affected by this treatment process. Few studies have examined the effect of parental BMT on the family, and there are no known studies which …
-
Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation
… response rates and survival after allogeneic bone marrow transplantation (BMT) or immunosuppressive treatment in severe aplastic anemia (SAA) and identified prognostic factors related with survival. METHODS: Medical data of SAA patients who treated with BMT or immunosuppressive therapy (IST) …
-
Effect of CDDO-me on Myelopoiesis in Naive Mice and Mice Undergoing Bone Marrow Transplantation (BMT)
… of CDDO-me on immune system recovery after bone marrow transplantation (BMT). Our findings show that CDDO-me at 240 μg/dose BID is a lethal dose for C57BL/6 female mice. In contrast, CDDO-me at 120 μg/dose BID was well tolerated in pre-BMT, but lethal in pre- and post-BMT and in post-BMT. …
-
Changes in Children's Sibling Relationships After Pediatric Bone Marrow Transplantation and Children's Adaptation: A Grounded Theory Approach
… changes in sibling relationships after pediatric bone marrow transplantation (BMT). Further investigation of the impact of sibling relationship quality on children's adaptation following this life-threatening medical procedure was examined. Two families, each consisting of a sibling dyad that …
-
Applications of Causal Inference Methods for the Estimation of Effects of Bone Marrow Transplant and Prescription Drugs on Survival of Aplastic Anemia Patients
… of treatment impacts, specifically focusing on bone marrow transplantation (BMT) and prescription drugs, and the identification of optimal treatment strategies.</p> <p>The first paper, "Causal Inference Analysis for Assessing the Effect of Bone Marrow Transplantation on the One-Year Survival of …
-
Targeting the hematopoietic stem cell to correct osteopetrosis
… of non-functional osteoclasts and the absence of bone resorption results in accumulation of sclerotic bone leading to abnormal bone marrow cavity formation insufficient to support hematopoiesis. The most common mutation is in the TCIRG1 gene seen in over 50% of the patients. The children suffer …
-
Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome
… </sup></em>mice after carotid ligation: bone marrow transplantation and celiprolol. Transplantation of <em>Col3a1<sup>+/+</sup></em> bone marrow to <em>Col3a1<sup>+/-</sup> </em>mice corrects the post-injury phenotypes, suggesting that bone marrow derived fibrocytes can be differentiated …
-
Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… receptor-ligand system and its role in bone marrow transplantation. In the first results chapter, we generated hybridoma clones producing monoclonal antibodies against another inhibitory receptor in the Nkrp1 receptor family, NKR-P1G via the CELLISA assay. Our results demonstrate that …
-
Effects of bFGF (Basic Fibroblast growth factor) on the Haematopoietic Sequelae that follow transplantation
Recovery following bone marrow transplantation is associated with the reduction in the clonogenic potential of stroma-adherent CD34⁺ progenitors. The bone marrow stroma is also affected, resulting in poor support for the growth of stroma-adherent multipotent progenitors that form blastic colonies …
-
Aging Exacerbates Neutrophil Pathogenicity In Ischemic Stroke
… counterparts. Our lab has recently shown that bone marrow transplantation from young mice into aged mice improves functional outcome after ischemic stroke, whereas aged bone marrow transplantation exacerbates secondary brain hemorrhage in young mice. However, the identity of the deleterious …
-
NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
… was ablated in HMΦs from Casp11KO mice. Bone marrow transplantation restored capacity for noncanonical pyroptosis in Casp11KO mice. RNAseq and microarray analysis revealed that lipid peroxidation and trained immunity mediate noncanonical pyroptosis in diet induced NALFD.
-
MULTI-ORGAN FAILURE DRIVEN BY TELOMERE UNCAPPING
… doses of ionizing radiation, including severe bone marrow hypoplasia, leukopenia, hematopoietic stem and progenitor cell dysfunction, and intestinal epithelium degeneration. Bone marrow transplantation failed to extend lifespan in Trf2 knockout mice, whereas it rescued the mortality caused by …
-
Lymph node and peri-lymph node stroma : phenotype and interaction with T-cells
… to autoimmune diseases, inflammation, and bone marrow transplantation.
-
Identification of Unique Hematopoietic Stem Cell Properties
… of engraftment capacity of dividing cells in bone marrow populations enriched for HSCs. Recent studies have suggested that HSCs might possess a much broader differentiation potential but in most cases the reported efficiency of such developmental plasticity has been rather low. We demonstrate …
-
Refining Our Understanding of the Hematopoietic Stem Cell Niche
… mechanisms by which HSCs are maintained in the bone marrow, so that they can be grown outside of the body and used in lieu of or in combination with bone marrow transplantation to treat hematopoietic illnesses. HSCs, as well as other somatic stem cells from different organ systems and organisms, …
-
Role of Il-17/Il-17Ra Signaling In The Pancreatic Tumor Microenvironment
… component using either genetic manipulation or bone marrow transplantation. Deletion of IL17RA from the pancreatic epithelial compartment delayed premalignant lesion development and resulted in increased tumor infiltration of cytotoxic CD8+ T cells. We used single-cell sequencing to gain insight …
Page 1 of 3