Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"bone marrow microenvironment"”.
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The influence of exercise training on the bone marrow microenvironment in obesity and cancer
… circulation. HSPCs primarily reside within the bone marrow (BM) in distinct niches that secrete soluble cytokines, growth factors, or utilize cell-to-cell interaction to regulate HSPC activity. The bone marrow niche is comprised of multiple cell lineages including endothelial cells, mesenchymal …
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
Dexamethasone therapy has been the backbone of myeloma treatment for the last few decades. Despite advances in chemotherapy, myeloma continues to be incurable and all patients eventually relapse with progressive disease. Cell adhesion mediated drug resistance and a permissive bone marrow …
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Regulation of Myeloid Leukemia Cells by Platelet Factor 4
… their interactions with and regulation by the bone marrow microenvironment deserve further exploration. Here, we examined the efficacy of the megakaryocyte-derived chemokine platelet factor 4 (PF4) to inhibit LSC proliferation and alter the course of AML disease progression in syngeneic mouse …
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Osteolyse beim Multiplen Myelom : Untersuchungen am Zellmodell
Myeloma is characterized by bone disease leading to severe bone pain and pathologic fractures. Only over the last few years the biochemistry of osteolysis in multiple myeloma has become clearer. A basic cytokine network responsible for balancing ostgenesis and osteolysis has been described …
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Roles of Oxidative Stress and Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression
… with poor prognosis in AML, alters the bone marrow microenvironment to promote the growth of myeloid progenitor cells, and activates oncogenic signaling in AML cells. My work highlights the potential for using smoking as a behavioral biomarker to help tailor treatment in AML patients.</p>
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Analysis of drug resistance and the role of the stem cell niche in leukaemia
… death mechanisms and the contribution of the bone marrow microenvironment to drug response/resistance all require investigation. Using microenvironment-mimicking conditioned media (CM), dexamethasone (a synthetic glucocorticoid) and etoposide to treat glucocorticoid-sensitive (C7-14) and …
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Understanding the role of extrinsic regulators in normal and malignant haematopoiesis
… HSCs could be maintained in the absence of the bone marrow microenvironment and allowed the identification of key factors dispensable for HSC function (Chapter 3). Next, to understand the role of extrinsic regulators in disease evolution I shifted focus to characterising the cytokine …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… treatments. Platforms mimicking the bone marrow microenvironment for expansion of hematopoietic stem cells (HSCs) are increasingly studied for cell therapies, but long-term ex vivo expansion of HSCs using the factors identified during these studies has not been achieved. Finally, …
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Runx1 in Primitive Hematopoiesis and Characterization of Hematopoietic Stem Cells in a Mouse Chronic Inflammatory Arthritis Model
… between hematopoietic stem cells and bone marrow microenvironment.<underline> There is an intricate relationship between hematopoiesis and bone homeostasis in normal physiological states during adulthood. By utilizing mice undergoing chronic inflammatory arthritis, we investigated the …
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BIOLOGICAL AND MOLECULAR CHARACTERIZATION OF CMA-03/06, A NEWLY ESTABLISHED INTERLEUKIN-6 INDEPENDENT VARIANT OF THE CMA-03 HUMAN MYELOMA CELL LINE.
… survival of multiple myeloma (MM) cells in the bone marrow microenvironment is regulated by functional complex interactions between the tumor cells and the surrounding bone marrow stromal cells mediated by adhesion molecules and the production of several cytokines of which interleukin-6 (IL-6) …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
… and immune cells in our body. Residing in the bone marrow (BM), HSCs are surrounded by numerous cell types and the associated extracellular matrix, which form a unique microenvironment known as ‘’HSC niche’’. Sympathetic neurons are important BM niche regulators, controlling HSC traffic in and …
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Nuove strategie per revertire la chemioresistenza nel Mieloma Multiplo
Il mieloma multiplo è una malignità ematologica caratterizzata da plasmacellule a differenziazione terminale, immunosoppressione e danno agli organi finali, comprese le lesioni osteolitiche. I pazienti presentano tipicamente infiltrazione midollare di plasmacellule clonali e proteine monoclonali …