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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"bone marrow derived mesenchymal stem cells"”.
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
Human mesenchymal stem cell (hMSC) is an attractive source of adult stem cells for the therapeutic use in regenerative medicine. These cells are usually culture expanded prior to their application. However, their proliferation and differentiation potential were gradually decreased during in vitro …
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Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… disease and stroke. Cell therapy using human bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture media of hMSCs and coculted hMSC using by transwell have effects against apoptosis induced SH-SY5Ys. SH-ST5Ys …
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Evaluation of allogeneic bone marrow-derived mesenchymal stem cells for use in equine joints: in vitro to preclinical evaluation
… translational model for human joint disease. Mesenchymal stem cells (MSCs) have been investigated as a treatment of musculoskeletal disease in the horse with autologous MSCs showing promise as a treatment of desmitis, tendonitis and joint disease including meniscal injury and osteoarthritis. …
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Reinforced chitosan-based heart valve scaffold and utility of bone marrow-derived mesenchymal stem cells for cardiovascular tissue engineering
… between the differentiation profile of mesenchymal stem cells (MSCs) and scaffold stiffness. Chitosan is being widely studied for tissue engineering applications due to its biocompatibility and biodegradability. However, its use in load-bearing applications is limited due to moderate to …
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Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture
… symptoms but do not modify progression. Mesenchymal stem cells (MSCs) have multi-modal properties but are ineffective in ameliorating equine OA. However, anti-inflammatory activities of bone marrow derived MSCs (BMSCs) are enhanced by three-dimensional spheroid culture so equine BMSC …
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
… tissue engineering the intervertebral discs to stem degeneration or to repair damaged tissues may be a realistic alternative. Adult bone marrow derived mesenchymal stem cells are undifferentiated, multipotent cells that have the ability to differentiate into the chondrocyte-like cells found …
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The behavior of rotator cuff tendon cells in three-dimensional culture
… plays a role in the contraction of smooth muscle cells, is expressed in the rotator cuff tendon cells. Previous investigations have been conducted to study PRG4 expression and distribution in different regions of the infraspinatus (ISP) tendon. The aim of this study was to investigate the behavior …
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Investigating The Role of Exosomal Communication In The Glioma Microenvironment
… human cancers are maintained by a population of cells with stem-like properties called cancer stem cells (CSCs). However, the influence of the surrounding stromal cells on the behavior of the CSCs remains poorly understood. We have recently shown that the micro-environment of human gliomas, the …
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The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
… in the United States. The high lethality of EOCs stems from rapid peritoneal involvement. EOCs frequently colonize peritoneal surfaces that overlie connective and adipose tissues. However, the mechanisms that enable ovarian cancer cells to readily adapt to the peritoneal environment are poorly …
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In Vitro Assessment of Bone and Cartilage Stimulating Peptides
… of this project is to develop a synthetic bone graft for the spinal fusion, combined with bone growth enhancing factors named bone and cartilage stimulating peptides (BCSP®). The focus of this present study is to assess BCSPs’ performance in various concentrations with respect to their …
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The human meniscus: transplantation, characterisation and tissue engineering
… appear to favor the fibrochondrocyte meniscus cells with a CAM rich in type I collagen and aggrecan and lower quantities of type II collagen, while monolayer cultured meniscus cells have considerable amounts of type I and II collagen but almost no aggrecan in their CAM. Additional …
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The role of autophagy in canine osteosarcoma
… osteosarcoma (OS) is a primary tumour in the bone and is mesenchymal in origin. The common sites affected are the metaphyseal regions of long bones, particularly the front limbs of dogs. Osteosarcoma in dogs shares many biological and clinical resemblances in humans with molecular and genetic …
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Inflammatory and Immune Effects of Intra-Articular Mesenchymal Stem Cells in Horses
Mesenchymal stem cells have demonstrated anti-inflammatory and immunomodulatory capabilities as well as modest efficacy in animal models of joint injury, warranting further study as a potential treatment of equine joint disease. The goal of the study is to investigate the inflammatory and immune …
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Collagen scaffolds in full- and hemi- resection spinal cord injury models
… are removed, axons in the central nervous system still require the appropriate stimulatory signals in order for significant regeneration to occur. These signals may include a substrate to provide directional guidance of the extending axon growth cones as well as neurotrophic factors to …
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The Effects of Low Intensity Ultrasound on Chondrogenic Differentiation of Rabbit Mesenchymal Stem Cells In Vivo
… of LIUS on chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs). The hypothesis is that LIUS may be a non-invasively effective stimulant to a biological system in vivo by turning on differentiation of MSCs and promotion of chondrogenesis. MSCs were isolated …
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The influence of equine bone marrow derived stem cells on the response of cultured peripheral blood mononuclear cells to endotoxin
… number of cell signaling pathways leading to a systemic inflammatory response. Activation of these pathways causes the release of a number of pro- and anti-inflammatory mediators. An overwhelming release of these mediators leads to the development of clinical signs associated with endotoxemia. …
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Development of methods for the tissue engineering of cardiac valves using mesenchymal stem cells
… not require drug therapies or re-operation. Bone marrow-derived mesenchymal stem cells have been shown to be capable of differentiating into a variety of lineages and may be advantageous as a cell source for tissue engineering applications. Attempts were made to isolate human and porcine …
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Homing of 111In-Labeled Bone Marrow Mesenchymal Stem Cells in Acute Brain Trauma Model
… vivo distribution of intravenously transplanted bone marrow-derived mesenchymal stem cells (BMSCs) in an acute brain trauma model by 111In-tropolone labeling and to perform the effect of 111In-labeling on the viability and functions of BMSCs. Rat BMSCs were labeled with 37 MBq 111In-tropolone. …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… result in permanent functional loss of damaged cells. Many researchers have looked for methods that will reduce secondary brain damage since there is no effective therapeutics to recover functional loss of damaged tissues. The severity of the secondary mechanism of TBI depends upon two factors: …
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… and the microsatellite populations of tumor cells scattered throughout the brain parenchyma. However, bone marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic delivery – one that overcomes current limitations. hMSCs are a population of cells …
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