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Showing 1 to 20 of 44 for “"bone marrow cells"”.
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The effects of fibroblast growth factor-2 om human bone marrow cells
Bibliography: leaves 163-191.
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Identification of the Downstream Effector Genes Involved in HOXB4-Induced Expansion of Hematopoietic Progenitor Cells
… expansion of hematopoietic stem and progenitor cells both<em>in vivo </em>and <em>in vitro</em>.<em> </em>However, the molecular mechanisms underlying this effect are not well understood. In order to identify direct target genes of HOXB4 in primary murine hematopoietice progenitor cells, we …
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Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
… of interleukin-10 on mast cell development from bone marrow progenitors.Materials and Methods. Unseparated mouse bone marrow cells were cultured in IL-3+SCF, giving rise to mast cells and monocytes/macrophages. The addition of IL-10, and the use of Signal Transducer and Activator of Transcription …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
NK cells are innate lymphocytes involved in the elimination of transformed, infected, stressed, antibody-coated and transplanted cells. The goal of this thesis, as well as the interest of our laboratory is to explore the MHC-independent “missing-self” branch of NK recognition, and more …
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In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia
… aberrations and PU.1 gene loss in mouse bone marrow cells. Loss of 1 PU.1 gene and missense mutation of the remaining allele leads to acute myeloid leukemia in CBA mice.
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Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells
… and IL-10 inhibit mast cell development from bone marrow progenitors. These studies encouraged our interest in other regulatory cytokines, including transforming growth factor β1 (TGF- β1). TGF- β1 has many cellular sources, one of which is CD4+CD25 regulatory T cells (Tregs). We wanted to …
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… shown that vasculogenesis, the process by which bone marrow-derived cells are recruited to the tumor and organized to form a blood vessel network de novo, is essential for the growth of Ewing’s sarcoma. We further demonstrated that these bone marrow cells differentiate into pericytes/vascular …
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In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production
… damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to …
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Novel Characteristics of Murine Bone Marrow-Derived Macrophages and Human Macrophage-Like Cells
… for novel properties of macrophages derived from bone marrow stem cells. In study 1, treatment of activated mouse bone marrow-derived macrophages (BMM) with either catecholamine synthesis inhibitors (α-methyl-para-tyrosine and fusaric acid) or the β2 adrenergic receptor antagonist ICI 118,551 …
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Characterization of Thy-1 expression on human hematopoietic cells
Hematopoietic stem cells have extensive proliferative capacity and the ability to produce daughter cells of all hematopoietic lineages. However, their characterization is complicated by their low frequency and the heterogeneous cellular composition of the tissues in which they are found. The …
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Regulation of Expression of a Retroviral Transforming Gene and its Cellular Homolog
… characterization of phenotypic revertants of rat cells transformed by FSV. Analysis of the defect of the two ts mutants of FSV revealed that P130 is the transforming protein of FSV and that its kinase activity plays a crucial role in cell transformation by this virus. v-fps, the transforming gene …
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AML1/ETO Downregulates the Transcription Factor PU.1 in Acute Myeloid Leukemia
… PU.1 by immunoprecipitation assay in Kasumi-1 cells having t(8;21). On mapping the region of interaction in PU.1, we found that AML1-ETO binds to the b3b4 region in the DNA binding domain of PU.1 and displaces the co-activator c-Jun from PU.1, thus downregulating PU.1’s transcriptional …
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A chromosomal analysis of bone marrow cultures of inbred mice
… to study variation's in chromosome number from bone marrow cells. Chromosome counts were made from 20 animals at each level of inbreeding except at the 73 percent level where only 13 animals were available. The chromosome number was determined for 24 countable cells per animal at each level, and …
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Immune Function Determination in Mice Dermally Exposed to Permethrin
… surface markers of thymocytes, splenocytes and bone marrow cells were not affected. Antibody production as shown by plaque forming cell (PFC) assay decreased significantly at 10 days after dosing termination. Taken together, these data indicate that low-level topical permethrin exposure may …
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Chromosome identification and analysis in selected lines of laboratory mice
… chromosome preparations were obtained from bone marrow cells of adult male and female mice. Two similar treatments were utilized in obtaining the chromosome preparations. The first treatment consisted of: 50 minute colchicine pretreatment, 30 minute hypotionic pretreatment, four-glacial …
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Porcine urinary bladder matrix in an in vitro equine model of tenogenesis
… and cell differentiation. Hydrogels seeded with bone marrow cells (n = 6 adult horses) were cast using rat tail tendon ECM ± UBM, fixed under static tension and harvested at 7 and 21 days for construct contraction, cell viability, histology, biochemistry, and gene expression. By day 7, UBM …
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
… expression of T505A in PU.1-/Spi-B null primary bone marrow cells in vitro conferred a proliferative advantage. No differences were observed for R392P and V444I. Using RNA-seq and gene set enrichment analysis, all mutations demonstrated altered gene expression and pathway enrichment. Notably, …
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Refining Our Understanding of the Hematopoietic Stem Cell Niche
… of studying blood-forming hematopoietic stem cells (HSCs) is to understand the mechanisms by which HSCs are maintained in the bone marrow, so that they can be grown outside of the body and used in lieu of or in combination with bone marrow transplantation to treat hematopoietic illnesses. …
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ΑΝΑΛΥΣΗ ΤΩΝ ΑΛΛΗΛΕΠΙΔΡΑΣΕΩΝ ΑΝΘΡΑΚΥΚΛΙΝΩΝ-ΣΙΔΗΡΟΠΟΡΦΥΡΙΝΩΝ ΣΤΟ ΑΙΜΟΠΟΙΗΤΙΚΟ ΣΥΣΤΗΜΑ
… HOWEVER,THEIR USE IS LIMITED DUE TO THEIR BONE MARROW (MYELOSUPPRESSION) AND CARDIOVASCULAR TOXICITY. UNFORTUNATELY, IT HASN'T BEEN A UNIFIED THEORY TO EXPLAIN THE PLEOTROPIC EFFECTS OF ADR ON SEVERAL TISSUES. THE OBSERVATIONS THAT HEMIN (IRON-PROTOPORPHYRIN IX) COUNTERACTS ADR-INDUCED …
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A Novel Transgenic Rat Model for the Study of Germ Cell Biology
… a transgenic line of rats expressing GFP in all cells of the body, a serendipitous integration of a ROSA-EGFP transgene resulted in exclusive expression of EGFP in the germ cells of both sexes. EGFP expression was uniform and robust in cleavage stage embryos beginning at the late 2-cell stage and …
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