Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"bone diseases"”.
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Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models
<p>Bone diseases and phenotypes are affected in multiple ways. We focused on studying the effects of genetic and environmental factors, especially their impact on bone properties. Firstly, we investigated the effects of β-caryophyllene (BCP), a naturally occurring dietary cannabinoid, on protecting …
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Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases
Osteoclast-mediated bone resorptive disorders, including post-menopausal osteoporosis, age-related bone loss, rheumatoid arthritis, and osteolytic bone metastases, affect over 55 million Americans each year. Breast cancer bone metastases, the model of bone resorptive disorders to be used here, …
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Plastic Embedding Techniques for Light Microscopy Histological Studies
… examination and investigation of metabolic bone diseases. As a result it was reported that the procedure had resulted in significant time saving without detrimentally affecting quality, and has been used for investigating approximately 10,000 cases of metabolic bone diseases for …
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
Osteoclasts are bone-resorbing cells essential for skeletal remodeling. However, over-active osteoclasts can cause bone degenerative disorders. Therefore, the level of NFATc1, the master transcription factor of osteoclast, must be tightly controlled. Although the activation and amplification of …
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The Impact of Acetylcholine Receptors on Osteocytes and Bone Mechanoadaptation
Bone’s ability to adapt to mechanical loads is attributed to the osteocyte. Osteocytes reside embedded in the calcified bone matrix, where they function as the resident tissue mechanotransducer. Calcium (Ca2+) signaling is a key second messenger in osteocyte mechanotransduction, however the details …
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Influence of Mechanical Stimulation on the Quantity and Quality of Bone During Modeling
Skeletal fractures due to bone disease impact an estimated 1.5 million Americans per year, creating a large economic burden on our society. Treatment of bone diseases prior to fracture often involves bisphosphonates (current gold-standard in osteoporosis care and prevention). Although …
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The Role of Wnt Signaling in Bone Mechanotransduction
… characterized by increased fracture risk and low bone mass. In skeletal tissue, canonical Wnt signaling is a critical regulator of bone mass, and dysregulation of the Wnt pathway has been implicated in numerous skeletal displasias. Some components of the Wnt signaling pathway have a clear role in …
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Synthesis and characterization of implants for bone substitutions made of biomedical apatites containing silicon
In the last decades the development of bone substitutes characterized by a superior biomimetism has become of particular interest, owing to the increasing economic and societal impact of the bone diseases. In the present work of research the development of bone substitutes characterized by improved …
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Application of Calcium Phosphate based gels for encapsulation of therapeutic molecules
There is increasing clinical need for bone substitutes because of the limited supply of autogenous tissue, and the significance of inherited or other bone diseases. The ultimate aim of this study was to form calcium phosphate (CaP) based matrices as bone grafts for medical applications. Amongst CaP …
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Involvement of Histone Deacetylase 4 (HDAC4) in Osteoclast Function
Bone modeling and remodeling during development and bone integrity throughout life are normally regulated via complex coupled actions of bone-resorbing osteoclasts and bone-forming osteoblasts. Loss of coupling between bone formation and bone resorption leads to pathogenesis of bone metabolic …
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Stress Along the Medieval Anglo-Scottish Border? Skeletal Indicators of Conflict-Zone Health
… prevalence rates of malnutrition and infectious diseases in addition to increased mortality. The aim of this study was to bridge the gap in literature between modern medical anthropology population studies of the health consequences of living in a conflict-zone and bioarchaeological population …
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The Role of IKKβ in Osteoclastogenesis and Inflammatory Osteolysis
Bone homeostasis is essential for health and is altered in many pathological conditions. A balance in the activity of osteoblasts: bone-building cells) and osteoclasts: boneresorbing cells) determines the state of bone metabolism, and a tip in this balance toward either cell type is detrimental to …
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Early Osteoclast Responses to a Calcium Supplemented Meal in Calcium Deficient Rats
… responsible for the mobilization of calcium from bone (bone resorption). It is a well known fact that bone diseases (i.e. osteoporosis and osteopetrosis) occur as a result of unbalanced cellular activity. The implicated bone cells include osteoblasts (bone forming cells) and osteoclasts. The …
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Multiscale characterization of mechanical and fracture properties of cortical bone specimens
Bone is a hierarchical material with multiple length scales ranging from mineralized collagen fibrils at the nanoscale, single lamella at the sub microscale, lamellar structure at the microscale, osteons at the mesoscale to a whole bone at the macroscale. Several fracture testing methods are …
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Functional Self-Assembled Poly (L-Lactide) Nanoparticles For Targeted Delivery of Bioactive Agents
… NPs an ideal carrier for applications such as bone tissue regeneration and cancer therapy. Bone diseases and cancer affect millions of people each year, and current treatments present limitations due to costs, side effects, and lack of compatibility. This work will focus on the applications of …
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Body composition especially external skeletal robustness in association with physical activity and recreation in pre-pubertal children : a national and international investigation
… may elevate the risk of cardiovascular diseases and skeletal modifications. Heredity and environmental factors as nutrition, socioeconomic status, physical activity and inactivity influence fat accumulation and the skeletal system. Based on these negative developments associations …
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The influence of nanotopographical structures on osteoblast adhesion formation and the functional response of mesenchymal stem cell populations
… of persons over 50 years of age affected by bone diseases will double by 2020 (Navarro et al., 2008). Clearly this represents a need for permanent, temporary or biodegradable orthopaedic devices that are designed to substitute or guide bone repair. Polymeric medical devices are widely used in …
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Mathematical modelling of bone remodelling at the cellular level and the interaction between myeloma cells and the bone microenvironment
After an initial phase of growth and development, bone undergoes a continuous cycle of repair, renewal and optimization, by a process termed remodelling. Bone remodelling is the coordinated processes of resorption by osteoclasts and formation by osteoblasts, where old bone is replaced by new bone. …
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Porous calcium phosphate granules for biomedical applications
… treatments and the spread of cancer and genetic bone diseases, has brought about the need to find solutions for patient care. To achieve this target/objective, biomaterials must simulate the body environment as much as possible and favour tissue repair by integrating them into the host site. …
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Cystic Fibrosis-Related Diabetes, Periodontitis, and Quality of Life in Adults with Cystic Fibrosis
… Other CF-related comorbidities like asthma and bone diseases as well as CF-related treatments like continued use of inhaled medications can also increase one’s risk for periodontitis. To date, there is no study that evaluated whether CFRD and other CF-related medical factors are associated with …
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