Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"bone development"”.
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Soft Tissue Composition, Cardiometabolic Risk, and Bone Development in Young Girls
… on the effects of obesity during childhood on bone development. Obesity and skeletal fragility have been previously thought to be two distinct conditions rarely found occurring in the same individual, as excess adiposity is thought to enhance bone strength due to the increase in mechanical …
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The role of E2f4 in cell cycle exit and bone development
… E2Fs and pocket proteins results in defective development and differentiation. Mutation of the most abundant E2F, E2F4, is known to disrupt the proper differentiation of several cell types, including erythrocytes and respiratory epithelium cells. Here, I analyzed a novel role for E2f4 in bone …
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Effect of maternal dietary fats on growth rate and bone development of commercial broilers
… of maternal dietary fats on growth rate and bone development of commercial broilers was examined. Addition of fats [soybean oil (SBO), menhaden oil (MO) and chicken fat (CF)] to the maternal diet altered the tissue and yolk composition of the hens to reflect the dietary fat source. Day-old …
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How do early environment, diet and physical activity interact to determine bone development in young children?
… & physical activity) in the determination of bone mineral accrual by aged 6 years, assessed by a) bone densitometry b) hip structural analysis c) pQCT measurement of the tibia in children born to mothers from the Southampton Women?s Survey.<br/><br/>Methods: Children were recruited at 6 years …
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Effects of Maternal Dietary Fats and Antioxidants on Growth Rate and Bone Development of Commercial Broilers
… of maternal dietary fats on growth rate and bone development of commercial broilers was examined. Three hundred fifty female chicks were winged banded, weighed and equally divided among six starter pens (1.52 X 3.66m) with litter floors. At 20 wk of age, each pen was fed a basal laying diet …
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Effects of Source and Level of Trace Minerals on Performance, Mineral Excretion, Intestine and Bone Development, and Immune Response in Commercial Turkeys
… on turkey performance, mineral excretion, bone strength, and carcass yield, day-old Hybrid poults (n=1,224) were randomly distributed to one of four treatments with 9 replicates. Experimental treatments consisted of: standard inorganic (SI) with a commercial supplementation program (Mn, Zn, …
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The Notch Target Hes4 Promotes Osteosarcoma Tumor Growth and Metastasis By Inhibiting Osteogenic Differentiation, and Has Potential As A Prognostic Biomarker For Newly Diagnosed Patients With High Grade Osteosarcoma.
… of these markers in OS pathogenesis. Because the development of OS is caused by genetic disruptions of osteogenic differentiation, we sought to identify pathways that are involved in normal bone development and homeostasis. One such pathway is the Notch signaling pathway. We hypothesized that the …
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Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells
… (HS)-binding growth factors, such as Wnt, bone morphogenetic proteins (BMP), and fibroblast growth factor (FGF), critically regulate cell fate decisions of ES cells. Here, we showed that HS-deficient derived from hESCs have impaired ability to differentiate into Brachyury-positive …
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Integrating biclustering techniques with de novo gene regulatory network discovery using RNA-seq from skeletal tissues
… the molecular and cellular processes behind bone development and the differences from cartilage formation. To further elucidate these processes would provide a means to analyze the relatedness of bone and cartilage tissue by determining genes that are expressed and regulated for stem cells to …
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Characterizing slc8a4b as an Osteoblast Marker in Danio rerio
… in zebrafish, enabling further study of healthy bone development, bone regeneration, and skeletal diseases. To guide future use of slc8a4b as an osteoblast marker, this study aims to identify which osteoblast functions slc8a4b expression is most closely associated with, describe where in …
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Investigation of age related changes to porcine cortical bone using nanoindentation and ash content
… on the characterization of porcine cortical bone during its development stage. The goal of this research is to gain a further understanding of cortical bone, and to obtain data that can be used for inputs and validation of a computational model of cortical bone and individual bone lamella. …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
During bone growth, remodeling, and fracture repair, skeletal lineage cell responses require the coordinated activation of multiple transcriptional programs. As defective genetic regulation of bone formation leads to both developmental and metabolic skeletal diseases, identifying and characterizing …
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Genetics of serum urate regulation in human health and disease
… processes including phosphate metabolism and bone development, glucose metabolism, adipocyte function and blood pressure regulation. I have additionally identified 15 lipids, some of which have a potential link with cognitive function. To approach the question of uric acid from a regulation …
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In vivo imaging of cortical porosity by synchrotron phase contrast micro computed tomography
Cortical bone is a dynamic tissue which undergoes adaptive and pathological changes throughout life. An improved understanding of the spatio-temporal process of remodeling holds great promise for improving our understanding of bone development, maintenance and senescence. The use of micro-computed …
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The influence of two physical activity programs on bone and muscle health in youth with cerebral palsy and other neuromotor impairments.
… physical activity is crucial for building strong bones, especially during childhood and adolescence when bones grow rapidly. During this time, physical activity, muscle-bone interactions, and gravity help stimulate bone development. However, in conditions that limit mobility, such as cerebral …
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Runx2 and Vascular Calcification
… factor 2) is a critical regulator of bone development, early chondrocyte proliferation, and hypertrophic chondrocyte formation. Surprisingly, Runx2 has been found to be upregulated in arteries of patients with atherosclerosis (intimal calcification) and CKD (medial calcification). …
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… important processes such as blood coagulation, bone development and viral and cell fusion. Activation of TMEM16 proteins requires the binding of intracellular Ca2+ to two highly conserved orthosteric binding sites in transmembrane helices (TM) 6-8 opens the permeation pathway formed by TMs 3-7. …
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The effect of dietary pH and phosphorus source on performance, gastrointestinal digesta, bone characteristics and body composition in weanling pigs
… digesta pH and chloride ion concentration (Cl⁻), bone characteristics and body composition. Pigs were blocked according to weight within sex and litters were balanced across groups. Treatments were randomly allotted within blocks to a 3 x 2 factorial arrangement with three dietary pH levels (5.4, …
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Metal-doped silicate microparticles for collagen scaffold-guided endochondral bone regeneration
… ossification (EO) describes a process in which bone tissue builds up via a cartilaginous phase. In contrast to classical biomaterial approaches, which address bone regeneration via direct, intramembranous ossification (IO), a collagen scaffold was shown to stimulate endochondral healing of large …
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Differential expression and phenotypic activities of osterix in equine mesenchymal stem cell populations
Bone is one of the few tissues in vertebrates that possess the innate capacity for authentic regeneration, yet approximately 10% of fractures fail to heal adequately. There is considerable overlap in the cellular and molecular events occurring during embryological bone development and fracture …
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