Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"bombesin"”.
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Radiolabeled Bombesin Analogs to Improve Prostate Cancer Diagnosis by PET Imaging
Le récepteur du peptide de libération de la gastrine (GRPR) est un récepteur couplé aux protéines G. Ce récepteur est fortement exprimé dans le cancer de la prostate, il est ainsi un biomarqueur potentiel pour ce cancer. La bombésine est un peptide de 14 acides aminés qui se lie avec une forte …
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Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
… remains incurable. Aberrant expression of the bombesin subtype 2 receptor (BB2r) is present on over 80% of human prostate cancer tissues evaluated. The BB2r binds with high affinity to the bombesin peptide (BBN), stimulating agonist mediated receptor-peptide internalization into the cancer …
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An assessment of the conformational profile of bombesin and its mammalian analogues using computational chemistry methods
Submitted in fulfilment of the requirements of the Degree of Doctor of Technology: Chemistry, Durban University of Technology, Durban, South Africa, 2011.
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Role of Histamine, and Its Interaction With Corticotropin Releasing Factor and Bombesin in Food Intake Regulation of Chickens
… with corticotropin releasing factor (CRF) and bombesin (BM) in food intake regulation of chickens. The hypothesis being tested was as follows: One component of the neuroregulation of food intake involves histaminergic activity in the hypothalamus, acting on either H1 or H2 receptors, how these …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
… method. Afterwards, three novel peptide (bombesin-OS, bombesin-PE and QUB2455) sequences were deduced from cDNAs and then confirmed by high performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS). The pharmacological effects of bombesin-OS and bombesin-PE were tested. …
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Experimental studies on the control and regulation of feeding in the common carp, Cyprinus carpio (L. )
… for the peripheral administration of bombesin and its effect on food intake. Animals held individually and feeding on an operant regime showed no indication that they were feeding in bouts. Satiety was seen to increase exponentially or logarithmically over the course of a feeding …
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Clinical translation of nanomaterials for early detection of genetic abnormalities in fetus and retinopathy in neonates and adults
… Re(V), 99mTc(V), and 186Re(V) with respect to bombesin for receptor targeting in the pancreas. While procedures for synthesizing 99mTc complexes is similar to other reported procedures, rhenium complexes were synthesized using [ReO(citrate)2] - as the starting material, simplifying purification …
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The Development of Peptide Analogues as Potential Fluorescent and PET Imaging Probes.
… to in vivo PET imaging. 69/71Ga-hematoporphyrin-bombesin analogues were synthesized as potential PET/fluorescence imaging probes for the gastrin releasing peptide receptor (GRP-R), but the reaction yields were low and all the components of the hematoporphyrin-bombesin mixture could not be …
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… fluorescent Alexa Fluor 680 and Alexa Fluor 750-Bombesin (BBN) probes to target gastrin-releasing peptide (GRP) receptors on prostate and breast cancer for optical molecular imaging. Confocal fluorescence microscopic imaging of the molecular probes for in vitro PC-3 prostate and T-47D breast …
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QUB-1073: a bioactive peptide from the skin secretion of Phyllomedusa rohdei
… the peptide had a similar sequence to several bombesin-like peptides which all had agonistic function on the neuromedin B (NMB) receptor (BB1).<br/>In conclusion, this study assessed QUB-1073 for several biological actions and found it to be potently myotropic. Considering sequence of peptide …
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Entwicklung neuer radioaktiver Kupferkomplexe hoher Stabilität auf der Basis sechszähniger 3,7-Diazabicyclo[3.3.1]nonan-Derivate
… anhand der Peptidsequenzen Neurotensin(8-13) und Bombesin(7-14). Dabei konnte demonstriert werden, dass eine Erhöhung der Ausbeuten an Peptidkonjugat ausgehend von Spacer-funktionalisierten Liganden erzielt werden kann. • Die radioaktive Markierung der Bispidin-Liganden mit den Radionukliden …
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Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
… that targets the bombesin receptor (BB2r) overexpressed in human prostate cancer. Two radionuclides, [203]Pb and [212]Pb, were selected due to their uniqueness as a chemically identical theranostic matched pair. Lead--203 (t1/2 = 51.9 hours) decays by electron …
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
… peptide (GRP), and its analogue bombesin (BBS), in neuroblastomas. Our lab also found that undifferentiated neuroblastomas express increased levels of GRP receptor (GRPR). Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a crucial regulator of cell survival, is …
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Molecular Mechanisms of Itch Sensations
… in the spinal cord. GRPR cell ablation by bombesin-saporin abolished general scratching responses to pruritogens. Because GRPR mutant mice still have remained itch responses, it is possible that additional itch mediators are present in the spinal GRPR neurons. Differential screening and …
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Ανάπτυξη, βιοκατανομή και φαρμακοκινητική μελέτη πεπτιδικών αναλόγων μπομπεσίνης επισημασμένων με διαγνωστικά ραδιονουκλίδια για την αντιμετώπιση του καρκίνου
Η παρούσα διατριβή αναφέρεται στην ανάπτυξη νέων πεπτιδικών αναλόγων μπομπεσίνης (ΒΝ) με απώτερο στόχο την ενδεχόμενη κλινική εφαρμογή τους στο πεδίο της διαγνωστικής ογκολογίας με SPECT (Υπολογιστική Τομογραφία Εκπομπής ενός Φωτονίου, Single-photon emission computed tomography) και PET (Τομογραφία …