Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"bloodbrain barrier"”.
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Genetic and Chemical Dissection of BloodBrain Barrier Development in Zebrafish
<p>The blood-brain barrier (BBB) maintains a homeostatic environment as well as prohibits the entrance of xenobiotics into the brain. Because of these qualities, drug delivery is a fundamental challenge for the treatment of many diseases of the central nervous system (CNS). Along with limiting the …
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Systemic and local signalling regulating neural stem cell proliferation
… signals from the fat body are transmitted to the bloodbrain barrier (BBB) glia on the surface of the brain. The glia secrete insulin-like peptides, which are received by the insulin receptor on NSCs, inducing their reactivation. To identify the fat body-derived signals sent to the brain, I used …
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Molecular Profiling and Mechanisms of Cerebrovascular Function in Health and Neurodegeneration
… nutrients. Furthermore, the presence of a bloodbrain barrier (BBB) provides protection to vulnerable neurons but poses a challenge for drug delivery. In neurodegeneration, BBB breakdown and vascular impairments are hallmarks that precede the onset of disease-specific phenotypes. Efforts to …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… brain and a blood to cerebrospinal fluid (CSF) barrier. The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) regulate the passage of many molecules to maintain and protect these sensitive organs from harmful xenobiotics (i.e. drugs, pollutants, etc.) or physiologic changes (i.e. glucose, …