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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 376 for “"blood-brain barrier"”.
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Radiation effects on the blood-brain barrier
… compounds are restricted to the lumen of the blood vessel, the resulting high-LET alpha and lithium particles cannot deposit their energy in the normal cells beyond the vasculature after the target is exposed to thermal neutrons. This allows for a 2- to 3-fold increase in the calculated dose …
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MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS
<p>The molecular interface of the blood-brain barrier (BBB) is a highly selective physiological barrier. The BBB shields the central nervous system (CNS) for harmful agents while also preventing lifesaving drugs from entering the CNS. With the prevalence of neurogenerative disease on the rise, …
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Systemic inflammatory regulation of blood-brain barrier inflammation
The endothelial cells of the blood-brain barrier are essential for the maintenance of homeostasis in the central nervous system. These cells act as a physical and transport barrier, restricting the movement of systemic immune cells and blood components into the brain. The physical barrier is …
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Regulation of P-glycoprotein at the Blood-Brain Barrier
… depression, epilepsy, multiple sclerosis, brain tumors, Alzheimer’s and Parkinson’s disease, as well as infections of the brain such as meningitis and HIV encephalitis. Consequently, there is a strong demand for effective treatments. However, pharmacotherapy of CNS disorders is greatly …
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Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
… using tissue sections and cleared half-brains showed that endotoxemia increased tracer penetrance into the brain parenchyma. Temporal and spatial distribution of tracers suggested that penetrance occurred across neurovasculature, choroid plexus, and circumventricular organs (CVOs). …
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Gene Delivery to the Blood-Brain Barrier for Ischemic Stroke Therapy
… (EXOs) / microvesicles (MVs)) to deliver brain-derived neurotrophic factor (BDNF) plasmid DNA (pDNA), a functional gene encoding a neurotrophin. In the first project, our data showed that DNA nanoparticles (NPs) with 0.03% P84 was a promising formulation to deliver Luciferase pDNA into …
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Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… are incompletely understood. Both increased blood-brain barrier (BBB) permeability and inflammation have been suggested to play a role. We hypothesised that BBB permeability and microglia activation would be increased in SVD and explored the relationship between these processes and other …
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Development of a physiologically accurate 3D blood-brain barrier hydrogel model
The blood-brain barrier (BBB) is a tightly interconnected network of cells that creates a semi-permeable barrier between the central nervous system and the rest of the human body, taking in nutrients and blocking/excreting waste/potentially toxic chemicals from the brain, maintaining the brain's …
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Technique for Repeatable Hyperosmotic Blood-Brain Barrier Disruption in the Dog
Reversible hyperosmotic blood-brain barrier disruption (BBBD) has been used in pharmaceutical research as well as human medicine to enhance drug delivery across the blood-brain barrier. However a technique for repeatable BBBD in the canine has not been described. This study describes a repeatable …
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Neurotoxic effects of malathion and lead acetate on the blood-brain barrier: Disruptive effects caused by different mechanisms examined with an in vitro blood-brain barrier system
… not only on the nervous system, but also on the blood-brain barrier (BBB). The BBB consists of specialized endothelial cells that form the vasculature of the brain; it regulates passage of nutrients, while preventing potentially damaging substances from entering the brain. The main feature of the …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… nervous system (CNS) diseases is limited by the blood-brain barrier (BBB), a selective vascular interface restricting passage of most molecules from blood into brain. Specific transport systems have evolved allowing circulating polar molecules to cross the BBB and gain access to the brain …
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Transport of Antibodies and Nanoparticles across An in vitro Blood-Brain Barrier
"The blood-brain barrier (BBB) is a dynamic interface between the blood circulation and the central nervous system (CNS). While it serves as a selective barrier to water and solutes to prevent the blood-borne toxins from entering into the brain tissue, it hinders the drug delivery to the CNS for …
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Supramolecular Structure-Enabled Delivery of Porphyrin to Glioblastomas Beyond the Blood-Brain Barrier
… resistance. However, the presence of an intact blood-brain barrier (BBB) within infiltrative tumor tissue restricts porphyrin delivery and, thereby, therapeutic efficacy. This thesis leverages the drug delivery advantages of porphyrin supramolecular chemistry to address this limitation through …
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Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
… the field of neuroscience, drug delivery to the brain and CNS remains a major challenge. Neurological diseases/disorders, infections, and brain cancers are becoming more predominant but effective drug therapies remain elusive. The blood-brain barrier (BBB) is a physical, chemical and metabolic …
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The Physical Mechanism of Blood-Brain Barrier Opening Using Focused Ultrasound and Microbubbles
… diseases resides in the safe opening of the blood-brain barrier (BBB), a specialized structure that impedes the delivery of therapeutic agents to the parenchyma. Despite the fact that several approaches have been successful in overcoming the BBB impermeability, none of them can induce …
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Unbiased assessment of P-gp efflux towards designing blood—brain barrier penetrant compounds
The student, Aya Kelly, accepted the attached license on 2022-04-15 at 10:24.
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Modeling HIV-1 Infection in the Brain: The Effect of the Blood-Brain Barrier
… As many ART drugs may fail to penetrate the blood-brain barrier (BBB), the long-term presence of viral RNA in the brain is considered to be associated with these disorders, such as early-onset dementia. \textit{In vivo} study of HIV infection in the brain is extremely difficult, and thus …
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A Cytochemical Evaluation of Blood-brain Barrier Sodium, Potassium- and Calcium-Adenosine Triphosphatase Polarity
<p>The blood-brain barrier (BBB) is formed by cerebral vascular endothelial cells. Brain ion and fluid homeotasis essential for proper neural functioning is due to the BBB. Sodium-potassium and calcium-activated adenosine triphosphatase (Na<sup>+</sup>, K<sup>+</sup>-ATPase and …
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