Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"blood pressure regulation"”.
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Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation
… Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation. Master of Science (Biomedical Sciences), December, 1999, 70 pp., 7 tables, 8 illustrations, references, 83 titles. This study was designed to test the hypothesis that an age-related vagal dysfunction compromises arterial …
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Blood Pressure Regulation by the Endocannabinoid System in Conditions Associated with Hypertension
Hypertension is associated with various conditions including obesity, type II diabetes and aging. Despite decades of research, the mechanisms involved in the development of hypertension are still poorly understood. Emerging evidence suggests hypertension is mediated by an imbalance in autonomic …
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Role of the Baroreflex in Long-Term Blood Pressure Regulation in Children Born With Very Low Birth Weight
… are at increased risk of developing elevated blood pressure (BP) later in life. One mechanism of short-term BP regulation is the baroreflex, which can be assessed by calculating baroreflex sensitivity (BRS). There is evidence in animals that the baroreflex may play a role in regulating BP on a …
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Estradiol regulation of the neurohypophysial hormones in the goldfish, Carassius auratus.
… as AVP is involved with fluid homeostasis and blood pressure regulation whereas OXT is involved with reproductive physiology. In teleosts, AVT plays a role in blood pressure regulation and both AVT and IST possess some overlapping actions in the induction of spawning or parturition in various …
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Structural and Molecular Basis for Multifunctional Roles of Cellular Proteases
… in many other biological processes including blood pressure regulation and virus infection. However, the knowledge gathered thus far is still limited regarding the underlying mechanisms for these functions. Therefore, my thesis research focuses on elucidating the structural and molecular basis …
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The Brain Renin-Angiotensin System: Biochemical Characterization and Possible Role in Hypertension
… to be involved fluid balance homestasis and blood pressure regulation. The data in this thesis provides additional evidence for a functional RAS in the brain and provides possible insight into the role of this system in the pathophysiology of hypertension.
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Structure, dynamics, and interactions of Angiotensin family of peptides with functional implications.
… in the Renin Angiotensin Aldosterone system for blood pressure regulation. Smaller metabolites of AngII, including AngIII, AngIV and Ang₁₋₇, have recently been discovered to play an important role in blood pressure regulation. Experimental structural characterization of these peptides, carried …
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Alterations in the Brain Renin-Angiotensin System in a Model of Fetal Programming
… exposure may lead to elevated mean arterial pressure and decreased autonomic function in young adults. Baroreflex sensitivity for control of heart rate is an important marker of autonomic function and is reduced in conditions associated with hypertension. Indeed, sheep exposed in utero to BM …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
… renal vs extrarenal ENaC in sodium retention and blood pressure regulation during pregnancy to do so we chronically blocked ENaC with either daily subcutaneous injections of benzamil (BZ) or intrarenal transfection of αENaC shRNA. Chronic ENaC blockade with benzamil prevented normal sodium …
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Genetics of serum urate regulation in human health and disease
… role in oxidative stress, inflammation, and the regulation of blood pressure. Excessively high serum urate levels (hyperuricaemia) are associated with a wide range of diseases. With the exception of gout, where monosodium urate crystals are known to trigger a painful inflammatory response, both …
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Stretch-Dependant Tonic Force Maintenance in Rabbit Epigastric Artery
… vascular smooth muscle (VSM) plays a key role in blood pressure regulation. Abnormal VSM contractility characterizes hypertension and understanding the regulatory mechanisms of VSM may provide some insights to specific treatment of hypertension. Upon muscle stimulation, Ca2+, myosin light chain …
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Electrical and Optogenetic Stimulation of Sympathetic Neurons to Stabilize Blood Pressure after Acute Spinal Cord Injury
… disability and autonomic dysfunction. Acute blood pressure instability is associated with poor long term neurological recovery. Despite current clinical standards of care, blood pressure instability still occurs in the acute phase, and the in-hospital mortality of patients with acute SCI …
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Characterisation of the Apelin Receptor and its Endogenous Ligands, Apelin and Elabela/Toddler in the Cardio-Renal System
… juxtaglomerular apparatus involved in systemic blood pressure regulation. Importantly, in models of kidney disease, the expression of both ligands were downregulated, but the receptor was not altered. In chronic kidney disease patients, plasma levels of both apelin and ELA were elevated. Using a …
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The Role of Oral Nitrate Reducing Bacteria in Cardiovascular Health: Impacts of Diet and Exercise
… the important role of oral bacteria in blood pressure regulation and vascular function through the NO3--NO2--NO pathway following exercise or dietary interventions. Study 1 examined the effect of antibacterial mouthwash on the oral microbiome and nitrate metabolism in vegetarians and …
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Investigation of slow oscillations in blood pressure
This thesis addresses blood pressure regulation from a mathematical modelling perspective. Blood pressure is controlled via a number of different negative feedback mechanisms. The baroreflex loop is the most dominant of these mechanisms for short-term control of blood pressure, and soft-limiting …
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Investigating domain-selective angiotensin converting enzyme inhibition and oxidative inactivation
… similarity). The C-domain is responsible for blood pressure regulation via angiotensin I cleavage while the N-domain inactivates an antifibrotic peptide Acetyl-Ser-Asp-Lys-Pro (AcSDKP). Since selective N-domain inhibition will result in AcSDKP accumulation, it shows promise for the treatment …
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Arterial Baroreflex Regulation of Sympathetic Discharge During Maximal Voluntary End-Inspiratory Apnea
… outflow during physiological stress to maintain blood pressure (BP) homeostasis. The arterial baroreflex represents a critical mechanism regulating sympathetic outflow during rest and physiological stress. Volitional apnea, seen in breath-hold diving, serves as a physiological stressor and a …
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Ultraviolet a irradiation on human skin : nitric oxide mediated cardiovascular responses
… correlation for both the systolic and diastolic blood pressure in mankind. A hypertension trial done by the Medical Research Council in the 1980s showed the average blood pressure being lower in summer than winter, and this difference was more significant in the elderly than the younger …
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