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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"blood platelets"”.
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Roles of coagulation factor XIII in the functions of blood platelets
Activated blood coagulation factor XIII (FXIIIa) is a transglutaminase that stabilises fibrin clots and associates with platelets. In the present study, the role of factor XIII (FXIII) in modulating physiological platelet functional responses including adhesion, signal transduction and spreading …
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Roles of coagulation factor XIII in the functions of blood platelets
Haemostasis is initiated following blood vessel injury to preclude loss of blood. It involves concerted actions of blood platelets and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their …
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Biochemical and pharmacological studies on blood platelets and erythmocytes in affective illness
… thesis describes various measurements made in blood platelets and erythrocytes from patients suffering from affective disorders, and the effect a variety of therapies have on these measures. No significant differences were detected in either platelet membrane ATPase or adenyl cyclase specific …
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Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets
… event, whose main role is to prevent excessive blood loss and repair vessel wall injuries. However, platelet activation must be controlled to prevent unwanted and exaggerated responses leading to the occlusion of the blood vessel. The endothelial-derived inhibitors prostacyclin (PGI2) and nitric …
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Lipoids and blood platelets with reference to blood coagulation and the hemorrhagic diseases
… for the various active principles of plasma, platelets, tissues and their fractions, much new information has been obtained concerning the role of lipoids and platelets in blood coagulation and in the hemostatic mechanisms in health and disease. Analysed components are studied in artificial …
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The Imipramine Binding Site: Effects of Aging, Ovarian Hormones, Adrenal Hormones, and Chronic Antidepressant Treatment
… imipramine have been described in the brain and blood platelets of several species of animals, including rats and humans. Decreased levels of imipramine binding sites are found in depressed patients when compared to controls.
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The influence of carrageenans on the cells and pathways of haemostasis and their role in immunosuppression
… the effects of defined carrageenan fractions on blood coagulation using plasma obtained from polysaccharide treated and untreated rats. Both in vitro and ex vivo samples were then subjected to amidolytic and functional clotting assays. Results obtained suggest that carrageenan is able to inhibit …
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Určování pohlaví kalouse ušatého (Asio otus) na základě PCR amplifikace DNA
… of captured Long-eared Owl by DNA isolation from blood platelets in the bird quail and subsequent PCR reaction. This thesis also describes the PCR method, which is one of the most used methods in the todays laboratories of many different field of science. I also mention the individual components …
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The mechanism(s) of post-transcriptional regulation of the human constitutive endothelial nitric oxide synthase gene by tumor necrosis factor-alpha
… first identified in endothelial cells lining the blood vessels. Its product, NO, plays a crucial role in the maintenance of vascular tone and homeostasis. Being a gas, NO can diffuse out of the endothelial cells into the underlying smooth muscle cells to cause vasodilation and into the lumen to …
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Fabrication of natural and magnetic slippery surfaces
… to reduce the adhesion of food, ice, and even blood platelets to surfaces. As a result, LIPS have applications in reducing food waste, aircraft and powerlines deicing, and hemocompatable implants. However, most LIPS are made of toxic fluorocarbon materials. In this work, in order to eschew …
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Novel blood platelet diagnostic platform
… platform to investigate the activation state of platelets. The final aim is to develop an assay to be used for diagnostic purposes. Blood platelets play a key role in the cardiovascular system. When the en- dothelium of the vessel wall is damaged platelets adhere and become activated, leading to …
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Regulation of blood platelet function by the AGC family of protein kinases
Upon vascular injury, platelets aggregate at the site of blood vessel injury to form a hemostatic plug maintaining the physiological integrity of the vascular system. Platelets respond to a variety of extracellular stimuli to undergo a rapid aggregation response, releasing active granule contents …
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Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling
… Hamberg and associates [1] discovered that human platelets transform arachidonic acid into prostaglandin endoperoxides then further into thromboxane B₂ through the unstable intermediate thromboxane A₂. Pinane thromboxane A₂ is a stable analog of the unstable thromboxane A₂ [2]. Its antithrombotic …
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Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram
… by the serotonin transporter (SERT). Since blood platelets express SERT, SSRIs may modify platelet function and the risk of cardiovascular disease. However, the beneficial or adverse effects of SSRIs on arterial thrombosis are poorly characterised and detailed in vitro experimental data is …
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The Relationship of Discrete Amino Acid Regions to the Biochemical Properties of Human Phenol Sulfotransferases (SULTs)
… variants) of SULT1A1 have been detected in human blood platelets at different proportions in separate ethnic populations. The SULT1A1 level of activity and thermal stability measured in the human population are variable. Allozymes are associated with the variability measured in human SULT1 Al …
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1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (Platelet Activating Factor): Interactions with Sheep Platelets
… events associated with the action of PAF on platelets are poorly understood, but PAF appears to interact with a platelet membrane receptor. Two photoaffinity-labelling analogs of PAF, diazoacetyl PAF and trifluorodiazoacetyl PAF, were designed for examining the interaction between PAF and its …
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The Requirement for Viable Platelets in the Coagulation of Heparinized Blood
… coagulation times (ACT's) of heparinized blood or plasma samples containing normal platelets were compared with ACT’s of heparinized samples containing non-viable or abnormally functional platelets. The non-viable platelets were prepared by freeze/thawing, and the abnormally functional …
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Effects of paraquat and diquat on the pulmonary and platelet disposition of 5-hydroxytryptamine
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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