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Showing 1 to 20 of 43 for “"blood group"”.
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Automated synthesis of the Lewis blood group oligosaccharides
Cell-surface carbohydrates are markers of specific cell types. These oligosaccharides are involved in recognition, adhesion, and signal transduction events. Advances in molecular glycobiology rely heavily on straightforward access to structurally defined oligosaccharides, but traditional syntheses …
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Enzymatic blood group conversion of human kidneys for transplantation
ABO blood group antigens present an immunological barrier in transplantation, restricting organ donor-recipient matches to blood group compatible pairings only. Due to the chronic shortage of donor organs worldwide, novel strategies to remove ABO blood group restrictions are desperately needed to …
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Association of Polymorphic Blood Group Systems and Relative Fitness in Pigs
… selected) over 7 generations were typed for blood factors in 12 blood group systems using 33 reagents. Boars in the selected lines were selected for high ('40)K count per unit weight. Both segregation analyses and least squares analyses of litter size and perinatal and preweaning …
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Biochemistry: Production of recombinant Rh blood group antigens for detection of alloimmunisation
… antigen/ antibody reaction, all hospitals and blood banks worldwide rely on routine blood group phenotyping of samples. Using recombinant antigens removes the disadvantage of the current antibody screening when using the human red blood cells, which can complicate the detection of antibody in …
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Affinity purification of blood group A-active glycolipids on immobilized Helix pomatia lectin
… glycolipids. Forssman glycolipid and a human blood group A-active hexaosylceramide were bound to the Helix pomatia column equilibrated in water/THF (5:95). After applying a step gradient of increasing water content (to 50% water), the specifically bound glycolipids were eluted when GalANc was …
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Studies on the genetic basis of Pk, P and P1 blood group antigen expression
The clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. The aim of this study was to …
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Characterisation of weak and null phenotypes in the KEL and JK blood group systems
… is on KEL and JK, two clinically important blood group systems, and the investigations of blood samples with aberrant antigen expression as in null and weak phenotypes, or with a phenotype that does not correspond to genotype. With the increasing use of DNA assays based on single nucleotide …
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Genetic Characterisation of Human ABO Blood Group Variants with a Focus on Subgroups and Hybrid Alleles
ABO is the most important blood group system in transfusion medicine and transplantation immunology. The ABO blood groups differ by the presence or absence of antigens on RBCs and antibodies in plasma. Accurate determination of ABO status is critical. Genomic typing can increase the precision of …
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Studies of the ABO and FORS Histo-Blood Group Systems: Focus on Flow Cytometric and Genetic Analysis
ABO is the clinically most important blood group system and its antigens are carbohydrate moieties present on the surface of the red blood cell (RBC) but also on other tissues throughout the body. The ABO gene encodes an enzyme, a glycosyltransferase (GT),that adds a terminal monosaccharide to the …
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Beyond the rare blood group Vel, uncovering the functions of SMIM1 in blood and in other organs
Vel is a universal antigen present on the red blood cells (RBCs) membrane, which defines the Vel-blood group system. The identification of Vel-encoding gene, SMIM1, suggested that this is a regulator of erythropoiesis. Its role in RBCs and potential role in other cells, however, remains largely …
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Parasitic infections and storage iron deficiency in children in improverished regions of Mauritius
… ferritin, haemoglobin concentration, white blood cells count, packed cells volume and blood group. It was found that there is a negative correlation between the number of parasites and haemoglobin concentration, packed cells volume of blood and degree of infestation, number of parasites and …
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Blood groups and the rise of human genetics in mid-twentieth century Britain
This dissertation reconstructs how blood groups were made into pre-eminent objects of human genetic research and powerful markers for producing human biological difference. By tracing the ways in which three British laboratories became international centres for blood-group genetic research, it also …
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Next Generation Sequencing-Based Genotyping of Human Blood Groups: FY, JK and ABO Genes
Serological discrepancies in matching blood group antigens between donors and patients for blood transfusion may lead to alloimmunisation, especially in multiply transfused patients. Blood group genotyping (BGG) has contributed in reducing this issue. ABO, Fy and Jk antigens are among those to be …
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A Study of Effects of Blood Types, Sires, Litter Size and Other Factors on Sex Ratios in Pigs
… were studied in association with 11 pig blood group systems, (A, B, C, D, E, F,G, H, J, K and L) in matings segregating for blood types and analyzed by using segregation ratios as well as by the least-squares method. Effects of sire, litter size and selection for high whole-body potassium …
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Identification and characterization of a receptor for Clostridium Difficile enterotoxin
… Toxin A did not bind to human erythrocytes from blood group A, B, or O donors. However, after fucosidase treatment of human erythrocytes, only blood group B erythrocytes could bind the toxin. This indicated that toxin A was likely binding to Ga1α1-3Ga1ß1-4GlcNAc, a carbohydrate sequence also …
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UNDERSTANDING THE MOLECULAR BASIS OF CELL DEATH MEDIATED BY ONCOSIS-INDUCING CYTOTOXIC ANTIBODIES
… A GLYCAN MOIETY STRUCTURALLY RELATED TO BLOOD GROUP H TYPE-1 EXPRESSED ON MULTIPLE GLYCOPROTEINS ON THE PLASMA MEMBRANE. MECHANISM OF CYTOTOXICITY WAS FOUND TO INVOLVE DETACHMENT OF THE PLASMA MEMBRANE FROM THE UNDERLYING CYTOSKELETON THROUGH INACTIVATION OF EZRIN, RADIXIN AND MEOSIN, AND …
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ΑΝΤΙ-HLA ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΠΟΛΥΤΟΚΩΝ ΓΥΝΑΙΚΩΝ: αξιολόγηση των συχνοτέρων ευαισθητοποιούντων αντιγόνων στον ελληνικό πληθυσμό και της χρησιμότητάς τους στην μεταμόσχευση νεφρού
… OF MULTIPOROUS SERE AGAINST ONBILICOUS BLOOD LYMPHOCYTES. THIS WAS PROVED TO BE AN EASY REPRODUCIBLE SCREENING METHOD. ON THE CONTRARY HLA TYPING ON THE SAME LYMPHOCYTES WAS UNSUCCESFULL IN ALMOST 75% CONCERNING THE COMASKING OF PATERNAL ORIGIN HAPLOTYPE. ONE OF OUR MAJOR FINDING WAS THE …
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