Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"blood clotting"”.
-
Blood clotting inspired polymer physics
The blood clotting process is one of the human body's masterpieces in targeted molecular manipulation, as it requires the activation of the clotting cascade at a specific place and a specific time. Recent research in the biological sciences have discovered that one of the protein molecules involved …
-
Control of blood clotting using gold nanorods
We have developed a method to externally control blood clotting using gold nanoparticles. Gold nanorods (NRs) have unique size and shape-dependent optical properties that can be used for externally controlled release of biomolecules by laser excitation. Femtosecond pulsed laser irradiation at the …
-
Polyphosphate modulates hemostasis, thrombosis, and inflammation
… activator of the contact pathway of blood clotting. These studies also implicate polyP in contributing to thrombosis and consumptive coagulopathies accompanying bacterial sepsis. PolyP polymer lengths are known to vary substantially among different organisms and cell types, with …
-
Polymers and colloids in flows : from dynamics to self-healing
… simulations. A special motivation comes from the blood clotting process. Our blood is a complex uid made of polymeric proteins and colloid-like cells. Controlled by ow, a blood-clotting protein (the so-called von Willebrand factor or vWF) can change shapes from a compact structure to an extended …
-
Contribution of different types of phospholipids in blood coagulation
… become activated and proper interaction of blood clotting proteins with membranes of activated platelets is essential for maintaining a balanced hemostasis. Hemophilia and thrombosis are the two extremes of an imbalanced hemostasis where patients with hemophilia suffer from severe bleeding …
-
Hemocompatibility of polymeric materials for blood-contacting applications
… terephthalate (PET); 3 potential materials for blood-contacting applications. The surface morphology was characterized using scanning electron microscopy (SEM), and surface wettability was characterized using contact angle goniometry. The cytotoxicity was investigated using lactate dehydrogenase …
-
Improving hydrophilicity of silicone elastomer by IPN formation with hyaluronan
… for platelet adhesion/activation and whole blood clotting. However, studies showed unfavorable results as the treated samples still caused platelet activation and blood clotting. Additionally, overall optical transmittance of the treated materials was significantly decreased. Further …
-
Towards atomistic characterization of blood coagulation proteins by NMR spectroscopy
Proteins involved in the blood coagulation cascade are of vital biomedical importance, and most essential blood-clotting reactions occur preferentially on phospholipid membranes. Understanding the interactions between the proteins and membranes involved in blood clotting is crucial to the continued …
-
In vitro anti-platelet aggregation activity of the extracts of protorhus longifolia
… of haemostasis is the underlying cause of blood-clotting related diseases. Concoctions of P. longifolia are used by Zulu traditional healers to manage such diseases. This work aimed at investigating the anti-platelet aggregation activity of the extracts of this plant and to identify and …
-
Computational modeling of extravascular platelet aggregation under flow
Platelets in blood aggregate as part of the normal physiologic response to a blood vessel injury. Extravascular injuries, those that occur outside the blood vessel, are not well understood and lack numerical tools to study them. In this research, we develop and validate numerical tools to study …
-
Blood coagulation reactions on nanoscale membrane surfaces
Blood coagulation requires the assembly of several membrane-bound protein complexes composed of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these procoagulant proteins, but can also affect their function. Increased exposure of …
-
ΦΩΣΦΑΤΑΣΗ ΤΗΣ 1,6-ΔΙΦΩΣΦΟΡΙΚΗΣ ΦΡΟΥΚΤΟΖΗΣ ΚΑΙ ΑΤΡ-ΔΙΦΩΣΦΟΥΔΡΟΛΑΣΗ ΣΤΟΝ ΑΝΘΡΩΠΙΝΟ ΠΛΑΚΟΥΝΤΑ
… ADP THUS PREVENTING PLATELET AGGREGATION AND BLOOD CLOTTING. THE PHYSIOLOGICAL ROLE OF THIS ENZYME WILLBE FURTHER INVESTIGATED WHEN THE ACTIVITY IS SOLUBILIZED AND PURIFIED.
-
Clot retraction
… the problem of the coagulation of the blood, this problem until quite recently could only be looked upon as being mainly of academic physiological interest. With the advent and daily increasing use of the highly dangerous anti-coagulant therapy for thrombosis and embolism, demanding at …
-
Improving blood compatibility of surfaces using tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers
Blood-contacting medical devices are indispensable in modern medicine but often cause complications like thrombosis, infections, and undesirable cellular responses. This research addresses these challenges through surface modifications using bio-derived polymers and nanoscale topographies. The …
-
High performance lattice boltzmann method yield-stress calculations based on intravital images of clot formation in live mice
… is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce …
-
Mechanistic Investigation of A Hemostatic Keratin Biomaterial
… the mechanism by which these proteins aid in blood clotting. Inspection of the amino acid sequence of known keratins shows the presence of several cellular binding motifs, suggesting a possible mechanism and potentially eliminating the need to functionalize the material's surface for cellular …
-
The Biochemical Pathway Leading to Lpa Generation Upon Blood Coagulation
… pathway responsible for LPA production during blood clotting is not fully understood. We have purified a phospholipase A<sub>1</sub> (PLA<sub>1</sub>) from thrombin-activated human platelets using sequential chromatographic steps followed by fluorophosphonate‑biotin affinity labeling and …
-
NMR investigations of blood coagulation: Conformational changes of membrane bilayers and proteins in blood coagulation
… investigate important interactions involved in blood coagulation. Structural and dynamics data of Ca2+-induced clusters of phosphatidylserine in membranes, important in blood clotting, is investigated using isotopically 13C, 15N-labeled phosphatidylserine in lipid bilayers. Finally, backbone …
-
Synthesizing a Heparin Mimic Material Derived from Cellulose Nanocrystals
To prevent clotting during dialysis, heparin is used to line the tubing which blood flows through. Unfortunately, many side effects arise from taking heparin, especially when it is used for an extended period of time. As such, long-term exposure for individuals undergoing dialysis every day is …
-
In vitro anti-platelet aggregation activity of the extracts of bulbine natalensis
… used by Zulu traditional healers to treat blood clotting-related diseases. The aim of this research was to test the anti-platelet aggregation effect of B.natalensis’ extracts on rat platelet aggregation separately induced by thrombin, ADP, collagen, epinephrine, papain, bromelain and …
Page 1 of 3