Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"blood clearance"”.
-
Development of Novel Macrophage Imaging Agents
… macrophage populations with exceptionally fast blood clearance times. In a heterotopic cardiac transplantation model of acute rejection the tracer 99mTc-SER4 demonstrated enhanced targeting to the rejected organ, whilst following recovery to localised bone marrow radioablation preliminary data …
-
Liposome Encapsulated Manganese Chloride as a Liver Specific Contrast Agent for Magnetic Resonance Imaging
… relaxation were used in experiments to study the blood clearance, liver uptake and vesicle break down. The results showed that the Mn$\sp{2+}$ must be released from the vesicle and transferred to some extent to hepatocytes in order to bring about effective relaxation enhancement in liver tissue. …
-
Toxicokinetics and structure/toxicity relationships of low molecular weight peptide toxins from cyanobacteria
… radiolabel from ($\sp3$H) 2H-MCLR present in the blood at one minute postdosing was cleared by 6 minutes. The blood clearance at the 75 $\mu$g/kg dose was slower than at the 25 $\mu$g/kg dose. Following administration of ($\sp3$H) 2H-MCLR at 75 $\mu$g/kg via the ileum, the maximal concentration of …
-
Pretargeted cancer radioimmunotherapy and radioimaging using antibodies and antibody fragments
… to achieve maximum tumor binding. This slow blood clearance results in high normal tissue irradiation and a poor therapeutic index. This is exemplified by the fact that to date, only two radiolabeled antibodies have been approved by the FDA for radioimmunotherapy of cancer. … …
-
Rational engineering strategies to improve antibody fragment pharmacokinetics and bioavailability
… SdAb also fall below the cutoff for first-pass clearance through the renal filtration system (50-60 kDa), leading to rapid blood clearance, which limits the efficacy of these potentially powerful therapeutics. Strong net negative charge has also been shown to decrease fractional kidney …
-
Quantitative analysis of perivascular antibody distribution in solid tumors
… that have shown efficacy in a range of blood and solid tumors. Antibodies targeting solid tumors face considerable transport barriers in vivo, including blood clearance, extravasation, diffusion within the tumor interstitium, binding to antigen, endocytosis, and degradation. The unique …
-
Supramolecular Structure-Enabled Delivery of Porphyrin to Glioblastomas Beyond the Blood-Brain Barrier
… resistance. However, the presence of an intact blood-brain barrier (BBB) within infiltrative tumor tissue restricts porphyrin delivery and, thereby, therapeutic efficacy. This thesis leverages the drug delivery advantages of porphyrin supramolecular chemistry to address this limitation through …
-
Exploring Critical Vehicle Parameters for the Design of Multitargeted Nanoparticles for Cancer Specific Gene Delivery
… surface protects against immune recognition and blood clearance. In this study, DNA was fully encapsulated within in stealth liposomes by complexing the macromolecule with a cationic polymer before encapsulation. Formation methods and material compositions were then investigated for their effects …
-
Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… low uptake in non-target tissues, and rapid blood clearance, preferably through renal excretion.
-
Dextran Magnetite as an NMR Contrast Agent
Made available in DSpace on 2017-07-06T18:42:13Z (GMT). No. of bitstreams: 3 Alameda_Jay_C_Jr_MS.pdf: 36399097 bytes, checksum: a08d9d029c3e486ed573a217b4bbf5e2 (MD5) Alameda_Jay_C_Jr_MS_ABS.pdf: 1261364 bytes, checksum: e54d7b39be48ea31cc1b6086ec21f499 (MD5) license.txt: 4813 bytes, checksum: …