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Showing 1 to 20 of 471 for “"blood cells"”.
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Depletant induced attractions in red blood cells
Red blood cells suspended in plasma are able to aggregate into linearly stacked rouleau. The aggregations can form complex clusters and branching networks which cause complications in various pathological cases. The self assembly and biophysics behind the aggregation of red blood cells into rouleau …
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Engineered red blood cells and their applications
The humble red blood cell (RBC) is the most abundant cell in the human body. Every second, a normal adult generates some 2.5 million RBCs, which subsequently circulate through the blood vessels for a lifespan of 50 or 120 days in mouse and human, respectively. RBCs are also unique in that they are …
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Numerical Simulation of Red Blood Cells in Capillaries
… to simulate the skeleton structure of the red blood cell (RBC) membrane and to study the RBC rheology with an immersed boundary method. We combine the above methodology with a distributed Lagrange multiplier/fictitious domain method to simulate the motion of a compound vesicle in a …
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Deformability of Plasmodium falciparum parasitized red blood cells
The biophysical properties of the human red blood cell (RBC) permit large deformations required for passage through narrow capillaries and spleen sinusoids. Several pathologic conditions alter RBC deformability that can result in abnormal circulation behavior. In the present work, altered RBC …
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EFFECTS OF RED BLOOD CELLS ON NITRIC OXIDE BIOACTIVITY
Red blood cells (RBCs) as one of important cells in human blood vessel are abundant in hemoglobin (Hb). Hb has four heme ferrous sites for binding oxygen, nitric oxide (NO), carbon monoxide (CO) and other small molecules. NO as an endothelial derived relaxing factor is involved in many …
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Computational analyses of blood cells: somatic evolution and morphology
Haematopoiesis is the complex process of blood cell production, carried out by haematopoietic stem cells in the bone marrow. Over the human lifespan, it generates quadrillions of cells which participate in essential bodily functions such as immunity (whiteblood cells), oxygen distribution (red …
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Characterization of apoptotic cell death in bovine red blood cells
Red blood cells (RBCs) in mammalian species display phenotypic variations in cellular functions and metabolism ascribed to their compositional and morphological differences. After accruing stress-induced damages, organelle-free human RBCs display a specialized apoptotic cell death process …
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Dynamic behavior of healthy and malaria infected human red blood cells
… molecular network and membrane of human red blood cells (RBCs). These structural changes lead to altered cell shape, deformability, cytoadherence and rheology which may in turn, promote the onset of vaso-occlusive events and crises that may ultimately cause pain, stroke, organ damage and …
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U0126, MEK1/2 inhibitor, Induces Adhesion Molecules Expression in Human Blood Cells
… transmigration and adherence to endothelial cells, causing inflammatory responses in vascular lesion. MAPKinase pathway has been known to be activated in inflammatory responses. In this study, we investigated the expression of adhesion molecule by MEK1/2 inhibotors such as U0126 in human …
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Forces on a wall-bound leukocyte due to flowing red blood cells
As part of the inflammation response, white blood cells (leukocytes) bind nearly statically to blood vessel walls before they transmigrate through the endothelium and exit the vessel. The inter-cellular interactions between the wall-adhered leukocyte and flowing red blood cells (erythrocytes) play …
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Modeling and Simulation of Shape Changes of Red Blood Cells in Shear Flow
… of the biomechanical character of red blood cells is given, along with an introduction to current computational schemes which use deformable capsules to simulate red blood cell shape change. A comprehensive two- and three-dimensional framework for the fluid-structure interaction between …
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Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells
… response, including dysfunctional peripheral blood immune cells has been described as part of the septic syndrome. Mitochondrial dysfunction has been suggested to be a contributing factor in the pathogenesis of these alterations and restoration of mitochondrial function has been implicated as …
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Identification and validation of Biomarkers for Breast Cancer from human White Blood Cells
… efficacy of breast cancer. Peripheral white blood cells (WBCs) carrying the information related to the presence of cancer, represent an attractive source for novel biomarkers. The main aims of the study were to develop the pipeline to discover and validate novel biomarkers in WBCs of breast …
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Environmental and age effects on methylation changes in human brain and blood cells
… predicted from DNA methylation in brain and blood tissues using two different algorithms, Random Forest and Linear Regression. Relationships between DNA methylation, genetics, disease and aging rate were also identified. Furthermore, the differences between the real ages and the predicted …
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Genomics-Based Analysis of Antibody Response to Sheep Red Blood Cells in Chickens
… titers in response to challenge by sheep red blood cells (anti-SRBC) have provided an investigative tool in the efforts to define molecular mechanisms that underlie vertebrate immune response. The overall objective of this dissertation research was to identify DNA markers associated with …
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Point-of-care microfluidic assays for measuring expression level of antigen on blood cells
… platforms for measuring nCD64 from whole blood without any off-chip sample preparation. Our first platform is an electrical biosensor that measures nCD64 by measuring the fraction of immunologically captured cells expressing CD64. It consists of a capture chamber, for immunologically …
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Simulation model of a microfluidic point of care biosensor for electrical enumeration of blood cells
… By utilizing the signals to count the number of cells coming into and out of a capture chamber that targets a specific antigen, we can obtain a quantitative measure of how many cells or beads were expressing the target antigen and use this for a diagnosis. First the simulation was tuned to be …
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Variability of Cholesterol Accessibility in Human Red Blood Cells Measured Using a Bacterial Cholesterol Binding Toxin
… to measure accessible cholesterol in human red blood cells (RBCs). Accessible cholesterol levels were stable within individuals, but varied >10 fold among individuals. Significant variation was observed among ethnic groups (Blacks>Hispanics>Whites). Variation in accessibility of RBC cholesterol …
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Bedside Washing of Stored Red Blood Cells: A Simple Apparatus Based on Microscale Sedimentation in Normal Gravity
… a short period without any alteration to current blood collection and storage practices. Washing pRBC units prior to transfusion is recommended for hypersensitive patients who have a higher susceptibility towards Allergic Transfusion Reactions (ATR) due to residual plasma proteins. Unfortunately, …
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