Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"blocking agents"”.
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The effect of calcium channel blocking agents on cold induced cerebral edema in mice
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Increased Control over Gold Colloid Adsorption on Substrates for Colloid Displacement Lithography
… work a variety of salts are used as potential blocking agents to prevent or modify the colloid adsorption. These include potassium iodide, potassium bromide, potassium chloride, sodium fluoride, sodiumsulfate, potassium hydrogen phosphate, potassium hydrogen phthalate, and sodium citrate. In …
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Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model
… in the human body. The use of neuromuscular blocking agents to inhibit neuromuscular transmission is sufficient to produce skeletal muscle paralysis, a mechanism used to facilitate muscle relaxation during surgery. Residual neuromuscular block postoperatively has been found to be a major risk …
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Adrenal steroid, blocking agent, and social stress effects on northern fowl mite population development on Leghorn chickens and toxicological evaluation of selected acaricides (Acarina: <i>macronyssidae</i>)
Administration of adrenal steroids or blocking agents at optimum doses influenced northern fowl mite development on chickens. Corticosterone at 20 ppm or desoxycorticosterone at 30 ppm in feed were most effective in inhibiting mite infestations. High levels of social stress increased resistance of …
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Characterization of Attachment and Receptor Isolation of Infectious Pancreatic Necrosis Virus to Chse-214 Cells
… with various proteolytic enzymes, reducing agents and specific blocking agents. IPNV attached optimally at a pH of 7.2-7.4 within 10 to 15 seconds at 23°c. Treatment of the monolayer with chyrotrypsin and neuraminidase decreased viral attachment at all concentrations tested. Protease at …
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A Rational Approach to the Design of Highly Effective Chiral Stationary Phases
… compounds, such as the (beta)-adrenergic blocking agents, propranolol and metoprolol (3,5-dinitrobenzoyl derivative), central nervous system stimulant amphetamine (3,5-dinitrobenzoyl derivative) and antiinflammatory agent ibuprofen (3,5-dintiroanilide derivative) also resolved quite well …
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Investigating the role of the Apicoplast in Plasmodium falciparum Gametocyte Stages
… novel targets for development of transmission-blocking agents. Furthermore, increasing drug resistance of the parasites to current antimalarials, including slowed clearance rates to artemisinin, requires the discovery of innovative drugs against asexual intraerythrocytic stages with novel …
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The Role of Escherichia Coli Endotoxins in The Pathogenesis of Lactation Failure in The Sow
… reserpine (0.025 mg/kg), and the DA receptor blocking agents, haloperidol (10 mg/sow) and chlorpromazine (0.5 mg/kg), were ineffective in elevating PRL concentrations when given on PP + 5 or PP + 6. TRH (500 (mu)g IM) elevated PRL for 20-30 minutes. These results suggested that PRL is not …
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Cancer Chemoprevention by Curcumin and Structurally Related Beta-Diketones
… related compounds, to act as effective blocking agents toward the initiation stage of chemically induced carcinogenesis. We have shown that curcumin can inhibit tumorigenesis when administered intraperitoneally. After screening various compounds for their capacity to induce …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… are likely candidates for immune checkpoint blocking agents.</p>
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A Study on the Modes of Action of Angiotensin on Isolated Smooth muscle Preparations
… were examined using known pharmacological blocking agents in selective concentrations. The results obtained suggest that the receptors for angiotensin are probably different in the same tissues from different species and in different tissues of the same species. Using a modified sucrose-gap …
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… also inhibits the efficacy of immune checkpoint blocking agents, implicating it as a promising target to improve the generation of anti-cancer immunity. Thus, the work in this thesis identifies the molecular control of therapy induced endothelial paracrine signaling and identifies a key role for …
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The neuroinflammatory basis of disease progression and cognitive impairment in Parkinson's disease
… study was to assess the tolerability of two TLR-blocking agents (Candesartan cilexetil and TAK242) and their efficacy in reducing TLR expression and protein levels over a two-month treatment in this model. This chapter showed a gradual increase in microglia in the brainstem, accompanied by an …
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Morphological and Physiological Examination of a Demyelinating and Remyelinating Lesion
… not by the administration of potassium channel blocking agents. Remyelination by either Schwann cells or oligodendrocytes was accompanied by the restoration of near normal conduction properties in virtually all of the affected fibers, as measured by the RPT, and the ability of the fibers to …
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Investigation of stability, dynamics and scope of application of mycobacterial porin MspA: a highly versatile biomolecular resource
… stable channels across DPhPC lipid bilayers. Blocking of the channel current via external molecules (i.e. channel blocking) is an extremely important process, which helps to evaluate the biosensor ability of the pore. In this regard, two Ruthenium based compounds, Ru(QP-C2)38+ (i.e. RuC2) and …
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Analysis of the Role of Bacillus oleronius Proteins in the Induction of Rosacea and Evaluation of Novel Therapeutics for the Treatment of Dermal and Ocular Rosacea
… of which help to treat patient symptoms. Three blocking agents were evaluated in this research to determine the potential capturing of B. oleronius antigens. Mucin is naturally present in tear fluid and protects the epithelial barrier. This antimicrobial displayed potential as an adhesive decoy …
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Biochemical studies on Oestradiol 17β in human mammary tumours and chemically induced rat mammary tumours
… apparently competitively, and by thiol blocking agents. Thiol containing compounds affected binding in varying ways:mercaptoethanol and dithiothreitoL were stimulatory, L-cysteine was inhibitory. The dithiothreitol effect was further investigated with respect to anti-oestrogen inhibition …
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Multi-Pronged Approach to Understanding the Toxicity Associated with CAR T-Cell Therapy
… armoured CAR T-cells capable of secreting blocking agents targeting the CCL2–CCR2 axis, the principal pathway of monocyte chemotaxis. Several approaches iv were tested, including secretion of eotaxin-3, scFvs, and a nanobody. While eotaxin-3 and anti-CCR2 scFvs showed limited efficacy, …
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Sulfato de magnesio en intubación orotraqueal sin relajantes musculares: revisión sistemática con meta-análisis y análisis secuencial de ensayos
En anestesiología, el Sulfato de Magnesio actúa como sedante, analgésico y relajante muscular. La sedación se debe a la inhibición del receptor NMDA, reduciendo los requerimientos anestésicos halogenados y propofol. En analgesia, modula el estímulo nervioso y disminuye la liberación de …