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Showing 1 to 11 of 11 for “"block copolymer micelles"”.
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Amphiphilic block copolymer micelles : creation of functional nanocavities and their use as nanocontainers for controlled release
Block copolymers in solution can self-assemble in to a variety of morphologies, with features on the nanometer length scale. This has lead to significant recent research into this assembly process and a wide range of potential applications. The exchange of block copolymer molecules between micelles …
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Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
… into nano-sized, biocompatible PEG-b-PCL block copolymer micelles (BCMs). Encapsulation of DTX in micelles via chemical conjugation or physical entrapment resulted in a dramatic increase in drug solubility and customizable drug release rate. The use of multicellular tumor spheroids (MCTS) …
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Probing diffusion and molecular dynamics to study self-assembly and intermolecular interactions in macromolecular and colloidal systems using NMR diffusometry and spectroscopy
… The materials under investigation include block copolymer micelles (BCMs), ligand-capped quantum dots (QDs), and linear polyelectrolyte chains – each with unique structural characteristics and promising applications. Block copolymer micelles are of particular interest for drug delivery …
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Developing New Methodologies for Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, and Applications as Imaging and Delivery Agents
… research includes the syntheses of amphiphilic block copolymers bearing functional groups through controlled radical polymerization techniques, followed by the aqueous assembly of these block copolymer precursors to construct polymeric nanostructures with different sizes and morphologies. …
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Block Copolymer Solutions: Transport and Dynamics, Targeted Cargo Delivery, and Molecular Partitioning and Exchange
Block copolymers have been extensively applied in diverse fields including packaging, electrolytes, delivery devices, and biosensors. Multiple investigations have been carried out on polymeric materials for cargo delivery purpose to understand how they behave over time. Block copolymer micelles …
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Smart organic-inorganic nanohybrids of functionalized silsesquioxane nanoparticles
… were used for the organic side: amphiphilic block copolymer micelles of poly(n-butyl acrylate)-block-poly(acrylic acid) and star-shaped poly(acrylic acid)s, the latter serving as a model system for frozen micelles. In all cases the mixing of aqueous solutions of anionic block copolymer …
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EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors
… and release kinetics of Pc 4 in biocompatible block-copolymer micelles, (2) Modify micelle surface with EGFR-specific ligands and investigate cancer cell targeting of the surface-modified micelles in vitro, and, (3) Investigate targeted PDT effects on SCC cell lines in vitro and suitable animal …
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Solution and Adsorption Characterization of Novel Water-Soluble Ionic Block Copolymers for Stabilization of Magnetite Nanoparticles
… models for brush extension and pair potential. Block copolymer micelles were first utilized for experimental validation by using the brush extension model to predict the size and the interaction model to predict the second virial coefficient, A2. Subsequently, the models were used to predict the …
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Efficient Drug and Nucleic Acid Delivery Systems based on Synthetic Amphiphiles with Tuned Oil/Water Interfaces
… novel oil/water interface-engineered amphiphilic block copolymer micelles that were previously introduced by our lab were assessed for their stability in the presence of various esterase enzymes present in serum and on blood vessel walls, normally encountered by drug delivery systems on route to …
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Hybrid Devices : Morphology Control by Self-Assembly
… dyes as well as well-controlled polymers and blockcopolymers. In the first part, BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) dyes were investigated which feature a broad absorption range up to the IR region accompanied by high extinction coefficients. These dyes were tested in solid …
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Effect of Encapsulated Species on Block Copolymer Micelle Self-Assembly
Due to their amphiphilic nature, block copolymers spontaneously form assemblies known as micelles in selective solvents. Minimization of the solution free energy drives the micellization process, with contributions from the polymer chains, surrounding solvent, and any additive molecules. Through …