Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"bleeding time"”.
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Autologous Fibrinogen Purification and Concentration For Use in Fibrin Sealant
… Kinetic experiments showed that the clotting time decreased as the thrombin and fibrinogen concentrations were increased. A rat model with controlled renal incisions was employed to evaluate the hemostatic efficacy of the fibrin sealant made from the protamine-fibrinogen concentrate. The …
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Antithrombotic and anti-inflammatory activity of ethyl acetate extract of Protorhus longifolia stem bark
… carrageenan induced rat paw edema and rat tail bleeding time models were used to investigate the anti-acute inflammatory and antithrombotic activity of the extract, respectively. The experimental rats were orally pre-treated with the extract at 100 and 350 mg/kg for 8 consecutive days. While the …
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An observational study to assess coagulation abnormalities in patients with elevated levels of urea and/or creatinine secondary to renal failure, presenting for renal biopsy – challenging conventional testing using visco-elastic testing
… of care in our institution to assess the bleeding risk in patients with renal failure (defined by a raised urea and/or creatinine level) presenting for a renal biopsy is to use the conventional tests of coagulation, including a bleeding time if their creatinine is above 300 µmol/L. The aim …
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The Chelating Effect of 5-(p-Acetoxy-Phenyl)-4,6 Dicarbethoxy Cyclohexanedione-1,3 on the Calcium Concentration of Human Blood Serum: Also the Anticoagulant Effect of the Above Compound
… (dog) will cause prolongation of the animal’s bleeding time, coagulation time or prothrombine time and thus serve as an anticoagulant. Toxicity is also to be observed. Derivatives of the above compound are used, because the parent compound is insoluble in water.
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Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice
… induces a transient, but significant increase in bleeding time. Using different genetically modified mice, it is shown that, upon antibody injection, GPVI is both, shed from the platelet surface and internalized into the platelet. Signaling through the immunoreceptor tyrosine-based activation …
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Studie zur Bedeutung der In-vitro-Blutungszeitmessung mit dem PFA 100 für die Vorhersage peri- und postoperativer Blutungskomplikationen in der Gynäkologie
Bleeding during or after operations is one of the most often complications in surgery. Until today there is still no valid test to prove a patient's bleeding habit preoperatively. In this study we proved the advantage of the new platelet function analyzer 100 (PFA 100™) compared to the standard …
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Some bioactivity of triterpenes from stem bark of protorhus longifolia and their derivatives
… activity was investigated using tail bleeding time assay and cotton pellet-induced granuloma model in Sprague-Dawley rats, respectively. The effect of the triterpenes on the expression of heat shock protein 70 (Hsp70) and their anti-protein aggregation activity using malate …
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A Study of Capillary Resistance in the Post-Operative Period and in Experimental Animals Following Trauma and in Relation to Adrenal Function
… of this phenomenon. Ungar (1944) at this time observed a definite uniform, rise in the capillary resistance in various animals following trauma. He also found that the sera of the traumatized animals when injected into normal animals caused a simultaneous change in bleeding time and …
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Effect of Levothyroxine Administration on Hemostatic Analytes in Doberman Pinschers with von Willebrand's Disease
… period between treatments. Buccal mucosal bleeding time (BMBT), vWf antigen concentration (vWf:Ag), vWf collagen binding activity (vWf:CBA), Factor VIII coagulant activity (FVIII:C), serum total thyroxine (T4), free thyroxine (fT4), 3,5,3â -triiodothyronine (T3), and thyroid stimulating …
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Platelet Function in Dogs with Chronic Liver Disease
… liver disease have prolonged platelet closure time (CT), assessed with the PFA-100®, and buccal mucosal bleeding time (BMBT), and increased vWF concentration compared to healthy dogs. Animals: Eighteen dogs with chronic acquired liver disease undergoing ultrasound-guided needle biopsy of the …
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Protective Effects of Yuzu and Its Component against Cardiovascular Disease
… of yuzu or hesperidin prolonged mouse tail vein bleeding time in a dose-dependent manner. LV remodeling in vivo study using the permanent left anterior descending coronary artery (LAD) occlusion model demonstrated that one week pretreatment with yuzu or its major metabolite hesperidin before LAD …
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In vitro and in vivo studies on the activating platelet collagen receptor glycoprotein VI in mice
… whereas it had only moderate effects on the bleeding time, probably because the treatment did not affect other activation pathways. These results establish GPVI as a potential pharmacological target for the prevention of ischemic cardiovascular diseases and may open the way for a completely …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… kit. The compounds were fed to rats and the tail bleeding time was used to determine the ex vivo anticoagulation activity of the triterpenoids. The anti-inflammatory activity of the triterpenes was investigated using the cotton pellet-induced granuloma model in rats. The homogenates from the …
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Cloning and targeted deletion of the mouse histidine rich glycoprotein gene and functional characterization of HRG in mice
… of a fixed amount of heparin. The prothrombin time was shorter in Hrg-/- mice than in Hrg+/- and Hrg+/+ mice. Bleeding time after tail tip amputation in Hrg-/- mice was shorter than in Hrg+/+ mice. The spontaneous fibrinolytic activity in clotted blood of Hrg-/- mice was higher than in Hrg+/+ …
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Generation and characterization of spred-2 knockout mice
… observation of Spred-2-/- mice was an increased bleeding phenotype after injuries, whereas the bleeding volume was extremely enlarged and the bleeding time was significantly prolonged. So far, hypertension as cause could be excluded, but to discover the physiological reasons for this phenotype, …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… polysaccharide from fucus vesiculosus, decreases bleeding time and clotting time in hemophilia, possibly through inhibition of tissue factor pathway inhibitor. However, its effect on platelets and the receptor by which fucoidan induces cellular processes has not been elucidated. In this study, we …
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Die Wirkung von niedrig dosiertem Desmopressin auf die durch Acetylsalicylsäure verlängerte Blutungszeit
… vWF-Moleküle, denen zum Beispiel die großen Multimere fehlen, reagieren. Direkt nach DDAVP steigt der prozentuale Anteil der großen vWF, sinkt dann aber sofort wieder und normalisiert sich innerhalb einiger Stunden, wie ergänzende Daten aus zusätzlichen Analysen an ausgewählten Proben dieser …