Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"bleeding disorders"”.
-
Rare bleeding disorders: diagnostic strategies and clinical features
Contains fulltext : 229980.pdf (Publisher’s version ) (Open Access)
-
RARE BLEEDING DISORDERS: INSIGHTS INTO CLINICAL PRESENTATION, LABORATORY PHENOTYPE, AND GENETIC CHARACTERIZATION
… stati caratterizzati tramite il Prospective Rare Bleeding Disorders Database, fornendo informazioni sui profili clinici, di laboratorio e genetici. I gradi di gravità emorragica corrispondevano alle soglie di attività dei fattori in quasi metà dei casi con difetti quantitativi di fibrinogeno. …
-
Study of patients with suspected platelet-based bleeding disorders: a search for patients with a defect in the P2Y12 ADP receptor
Mild platelet-based bleeding disorders are among the most complex bleeding disorders to understand, due to the absence of a ‘gold standard’ test for diagnosis and the significant overlap with the bleeding phenotype observed in healthy individuals. The work in this thesis is focussed on patients …
-
Evaluation of the determinants and characterization of bleeding in hemophilia A and B carriers
Hemophilia A and B are bleeding disorders caused by a deficiency in coagulation factor VIII (FVIII) or coagulation factor IX (FIX), respectively. Due to the X-linked inheritance pattern, males are affected with the disease, while females are almost exclusively carriers of hemophilia. Although …
-
An investigation into the understanding of basic genetic inheritance amongst amaXhosa caregivers of patients with Haemophilia
… caregivers of patients with the genetic bleeding disorder haemophilia. Haemophilia A and B are X-linked recessive inherited, lifelong bleeding disorders that are caused by deficiencies in blood clotting factors. The condition predominantly affects males, while females are carriers and …
-
Haemophilia 2010; an exploration of the lived experience of boys with haemophilia
… infusions every other day to prevent bleeding. This means that children can lead near normal lifestyles, yet it is not normal to be expected to learn to self-infuse and self-manage a long term condition from a young age. This thesis provides a cohesive body of work examining life with …
-
Biochemical And Genetic Studies of Quebec Platelet Disorder
<p> Inherited bleeding disorders can be caused by mutations affecting platelet, coagulation, or fibrinolytic proteins. Quebec platelet disorder (QPD) is a rare, autosomal dominant disorder associated with increased expression of the fibrinolytic enzyme urokinase plasminogen activator (uPA) in …
-
Predictors and Outcomes of Pica
… other comorbid conditions, psychiatric disorders, behaviors and laboratory markers in children and adults. We also studied health outcomes of pica including but not limited to hospitalizations in children and adults. This is a case-control study of 7,684 patients aged 2 to 64 years who …
-
Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
… arterial hypertension, heart failure, and bleeding disorders, where the receptor also mediates antithrombotic responses. Here, four novel fluorescent ligands, designed as functional analogues of endogenous apelin and ELA peptides, were validated and used as a versatile tool for the …
-
The experiences of caregivers caring for patients with haemophilia in rural areas
… Most people in rural areas lack insight on bleeding disorders because of their cultural beliefs; as a result, they fail to be supportive of the patients and their caregivers. However, there are a few people who do understand the nature of haemophilia as a disorder when it is explained to …
-
Lipoids and blood platelets with reference to blood coagulation and the hemorrhagic diseases
… thrombin- forming system. Some 86 cases of bleeding disorders, 32 new born normal infants and their mothers, and many normal adult bloods have been analysed with respect to components of the clotting and hemostatic functions. The detailed considerations embodied in the thesis are encompassed …
-
Label-Free Functional Imaging Of Platelets At Nanoscale
… haemostatic plugs that have wide application in bleeding disorders and cardiovascular diseases. During clotting, individual platelets sense physical and biochemical agonists on their surface receptors that trigger the formation of membrane protrusions. Platelets would reorganize their …
-
Label-Free Functional Imaging Of Platelets At Nanoscale
… haemostatic plugs that have wide application in bleeding disorders and cardiovascular diseases. During clotting, individual platelets sense physical and biochemical agonists on their surface receptors that trigger the formation of membrane protrusions. Platelets would reorganize their …
-
Reducing Maternal Morbidity from Peripartum Hemorrhage in Cesarean Delivery
… hypertension, diabetes, chronic steroid use, and bleeding disorders) with maternal hemorrhage. Peripartum and postpartum clinical outcome analytic variables include postoperative diagnosis, blood transfusion administration, sepsis occurrence, and days from operation to discharge. The relationship …
-
Pathogenicity assessment of genetic variants in von Willebrand disease using quantitative, qualitative, and functional approaches
… disease (VWD) is the most common inherited bleeding disorder. It is defined by a deficiency or dysfunction of plasma von Willebrand factor (VWF), a glycoprotein with a multifaceted role in haemostasis. The majority of circulating VWF is synthesised and released by endothelial cells (ECs). …
-
Investigating the role of rare genetic variants in the aetiology of haemostasis disorders
… the genetic bases for thousands of Mendelian disorders have been identified. However, providing a molecular diagnosis for these conditions remains challenging, and a considerable portion of patients with inherited conditions still lack a genetic diagnosis. In clinical genomics, identifying the …
-
Development of novel approaches for industrial fermentation of menaquinone-7
… 1929, is capable of correcting dietary-induced bleeding disorders in chickens. It is essential for blood coagulation, and therefore must be supplied in the diet. Menaquinones (MK) together with phylloquinone (PK) fall under the common name ‘vitamin K’. Recent studies show that dietary intake of …
-
Fermentation of vitamin K2 (menaquinone-7): Development of an optimal fermentation process to selectively enhance the production of the biologically significant all-trans isomer
… factor capable of correcting dietary-induced bleeding disorders in chicks. The vitamin K family encompasses a series of structurally related compounds, namely vitamin K1 (phylloquinone), vitamin K2 (menaquinones), and vitamin K3 (menadione), which share a common 2-methyl-1,4-naphthoquinone …