Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"blebbistatin"”.
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The rule of Myosin II and Rap2 in synaptic structure and function
… thin, filopodia-like structures. Treatment with blebbistatin, a chemical inhibitor of myosin II, phenocopied this result. Live imaging revealed that mature spines unravel into filopodia within tens of minutes of myosin II inhibition by blebbistatin. Furthermore, blebbistatin treatment led to …
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Synthesis and Structure-Activity Relationship Studies of 3-(N-Butylethanimidoyl)-4-hydroxy-2H-chromen-2-one (BHC) Analogues for Myosin II Inhibition
… various isoforms of muscle myosin II including blebbistatin. Recently a coumarin based Schiff base, 3-(N-butylethanimidoyl)-4-hydroxy-2H-chromen-2-one (BHC), was found to inhibit myosin II. The structure-activity relationship (SAR) study of BHC analogues are performed in this study. To implement …
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The role of actomyosin contractility in zebrafish neural tube formation through hollowing.
… myosin II (NMYII) contractility with the drug Blebbistatin over the course of cell polarisation, apical surface generation, and lumen inflation. This resulted in a narrower lumen, collapsed tissue shape, and buckled apical surface. The apical surface buckled at hinge points which suggests a …
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Application of a Novel Quasi-3D Microscopy Technique to Investigate Early Osteocyte Mechanotransduction Events
… down the kinetics of contraction initiation, but blebbistatin, a potent skeletal and non-muscle inhibitor, had no effect on the actin contraction. Furthermore, smooth muscle contraction-related proteins were detected by Western blot. The observation of muscle-like contractility in osteocytes …
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The role of protein phosphorylation in the switching between modes of synaptic vesicle release
… fusion pore. Likewise, inhibition of myosin 2 by blebbistatin also revealed that with some stimuli this protein might also regulate the kinetics of the fusion pore opening. Intriguingly, there were some differences between these two inhibitors and the effects that they had on specific stimuli. …
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Arrhythmia mechanisms in acute ischaemia and chronic infarction in rabbit heart
… artefacts were practically eliminated with blebbistatin (5µM). An alternative mechanical uncoupler, BDM, was found to be not suitable for the study of arrhythmic behaviour associated with ischaemia. After occlusion of the left coronary artery, a progressive reduction in action potential …