Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"blast exposure"”.
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The Post Deployment Lived Experience of U.S. Military Troops after Combat-Related Blast Exposure
Blast-induced neurotrauma (BINT) is a newly emerging re-occurrence of an old combat-related injury in U.S. military troops returning from deployment in Afghanistan and Iraq. BINT is leading to a silent epidemic of symptomatic troops who face barriers to accessing healthcare and suffer debilitating …
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Investigating Injury Pathology of Blast-induced Polytrauma and Assessing the Therapeutic Role of Hemostatic Nanoparticles after Blast Exposure
… combat related injuries (Ramasamy et al. 2008). Blast overpressure from explosions can cause barotrauma to the lungs and the brain. Blast-induced mild traumatic brain injury has been labeled the "signature wound" of current military conflicts in Iraq and Afghanistan (Snell and Halter 2010). In …
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Silencing ITGB3 in Astrocytes
… The samples were then exposed to a simulated blast, and after blast exposure, the protein levels were assessed. Blast exposure significantly increased ITGB3 protein and mRNA levels 48 hours after injury. Based on the 48 hour time point, a gene silencing technique was used to successfully lower …
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The Biomechanical Response of the Eye, Face, and Orbit to Primary Blast Overpressure
Combat-related blast injuries are occurring more frequently with the increased use of improvised explosive devices in current military conflicts. Though much research has focused on how the body responds to the relatively low loading rates associated with blunt trauma, little is known regarding the …
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The Effects of Blast-Induced Neurotrauma on Blood-Brain Barrier Permeability, Cell-Cell Junction Protein Levels and the Role of Peroxynitrite
… challenge for researchers and clinicians alike. Blast-induced Neurotrauma (BINT), often caused by improvised explosive devices (IEDs), is an injury that affects military personnel, however, the increasing threat of worldwide terrorist attacks makes this a concern for all individuals. Many of …
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Biomechanical Responses and Functional Outcomes in Large Animal and Human Surrogate Models of Primary Blast Injury
… over the past century has led to a rise in blast traumatic brain injuries (bTBIs), particularly among military personnel. More than 515,000 servicemembers have been diagnosed with a traumatic brain injury (TBI) since the year 2000, and blast was reported to be the most common cause of TBI in …
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The Influence of Biomechanics on Acute Spatial and Temporal Pathophysiology Following Blast-Induced Traumatic Brain Injury
Blast-induced traumatic brain injury (bTBI) remains a significant problem among military populations. When an explosion occurs, a high magnitude positive pressure rapidly propagates away from the detonation source. Upon contact, biological tissues throughout the body undergo deformation at high …
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Ultrastructural damages in the brain induced by low-intensity primary blast wave : a transmission electron microscopy study on mild traumatic brain injury
… AT AUTHOR'S REQUEST.] Explosive blast-induced mild traumatic brain injury (mTBI), a "signature wound" of recent military conflicts, commonly affects Service Members. While past blast injury studies have provided insights into TBI with moderate-to high-intensity explosions, the …
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Pro-oxidative and Pro-inflammatory Mechanisms of Brain Injury in Experimental Animal and 3D Cell Culture Model Systems
… and cellular mechanisms responsible for blast- and radiation-induced brain injuries and (2) Development of a three-dimensional (3D) model system in order to mimic in vivo-like microenvironments to further broaden our knowledge in pro-oxidative and pro-inflammatory mechanisms and their …
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Impaired Behavioral and Pathological Outcomes Following Blast Neurotrauma
Blast-induced neurotrauma (BINT) is a major societal concern due to the complex expression of neuropathological disorders after exposure to blast. Disruptions in neuronal function, proximal in time to the blast exposure, may eventually contribute to the late emergence of the clinical deficits. …
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Blast-Induced Tinnitus: A Combined Behavioral, Memri, And Electrophysiology Study
<p>ABSTRACT</p> <p>BLAST-INDUCED TINNITUS: A COMBINED BEHAVIORAL, MEMRE, AND ELECTROPHYSIOLOGY STUDY</p> <p>by</p> <p>JESSICA OUYANG</p> <p>May 2014 Advisor: Drs. Steve Cala & Jinsheng Zhang</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>Tinnitus and hearing loss are the …
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Experimental and Finite Element Evaluation of Mild Traumatic Brain Injury
… and biological impacts of mTBI induced by blast exposure and rapid acceleration, focusing on both experimental replication and finite element (FE) modeling. In experimental studies, using a custom-built shock tube, this study replicated blast-induced TBI (bTBI) in rats, examining the …
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Development of a Workflow to study Neuronal Injury In Vivo in the Retina and In Vitro in Collagen Hydrogels
… et al., 2023). In the military, the frequency of blasts has increased during recent military conflicts where 186,555 active-duty military personnel are now diagnosed with ocular injuries (Hilber, 2011). This study used in vitro and in vivo models to determine the cellular responses to mechanical …
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Evaluating Microglia Dynamics in Blast and Impact-Induced Neurotrauma and Assessing the Role of Hemostatic Nanoparticles in Microglia Activation
… of explosive devices during combat has caused blast TBI (bTBI) to become a widespread consequence in military and Veteran populations, and impact-related trauma from contact-related sports or motor vehicle accidents has made mild impact-induced TBIs (concussion) a major health problem. There is …