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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"bitopic"”.
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Introduction of a Novel Family of Bitopic N-Heterocyclic Carbenes
<p>Catalysts lower the energy barrier of different reactions and can provide greater selectivity with higher yields and therefore are of particular interest to material production. Improvement in catalysts can lead to greener production and a decrease in cost. N-heterocyclic carbenes (NHCs) have …
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<em>Agrobacterium</em> Virb10 Contributions to Type Iv Substrate Secretion, T-Pilus Biogenesis, and Outer Membrane Pore Formation
… through a mutational analysis. VirB10 is a bitopic protein with several domains, including a: (i) cytoplasmic N-terminus, (ii) single transmembrane (TM) α-helix, (iii) proline-rich region (PRR), and (iv) large C-terminal modified β-barrel. I introduced cysteine insertion and substitution …
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Structural characterization of the type II secretion system of Aeromonas hydrophila
… hydrophila codes for a 31 kDa, three domain, bitopic inner membrane protein. The components of the ExeC protein include an amino-terminal cytoplasmic domain, a trans-membrane helix and two periplasmic domains. The two periplasmic domains are involved in recognition and selection of protein …
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DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS
… the required D2/D3 receptor agonist properties. Bitopic compounds with the above cited molecular features should ideally inhibit dopamine release, a condition that could be exploited in therapeutic protocols for nicotine addiction. On the other hand, the synthesis of bivalent derivatives …
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The bacterial actin-like cell division protein FtsA forms antiparallel double filaments upon binding of FtsN
… The late divisome component FtsN is a bitopic membrane protein that activates peptidoglycan synthesis. Recent genetic studies have suggested that the interaction of FtsA and FtsN is crucial for divisome integrity and function. So far biochemical and structural evidence for the FtsA-FtsN …
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Insights into the Energetics of Membrane-Bound Peptides : Towards an Understanding of the Structural Organisation of Membrane Proteins
… of membrane proteins, namely the monotopic and bitopic peptides. Analysis of several aspects of these peptides such as their orientation, electrostatics and association is reported here. The environment of these peptides is represented by a continuum model that distinguishes between water, …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
… the mature glycoprotein complex, SSP assumes a bitopic membrane topology with both its N and C termini in the cytosol, and a short ectodomain loop. This membrane orientation allows it to mask the endogenous endoplasmic reticulum retrieval signals in the cytoplasmic tail of G2 thereby allowing …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
… the mature glycoprotein complex, SSP assumes a bitopic membrane topology with both its N and C termini in the cytosol, and a short ectodomain loop. This membrane orientation allows it to mask the endogenous endoplasmic reticulum retrieval signals in the cytoplasmic tail of G2 thereby allowing …
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Characterisation of novel alpha1-adrenoceptor ligands
… interacted with a second allosteric site in a bitopic manner. 4-aminoquinoline, C9, C10, and C11 increased the dissociation rate of [3H] prazosin from the α1A-AR, suggesting allosteric modulation. C9 was further characterised and demonstrated to be a negative allosteric modulator of orthosteric …