Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 56 for “"bisphosphonate"”.
-
Bisphosphonate-related osteonecrosis of the jaw
Bisphosphonates (BP), potent osteoclast inhibitors, play a key role in managing patients with osteoporosis, Paget’s disease, bone metastasis, and multiple myeloma. BP’s anti-resorptive activity substantially reduce fracture risk by 40%-70% in osteoporosis patients, and improve quality of life in …
-
ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
… part of this work, the mechanism of action of bisphosphonates against cancer cell lines were studied. There are two types of bisphosphonates described in the literature: nitrogen containing (NBPs) and non-nitrogen containing bisphosphonates (NNBPs). These drugs are a major class of drugs …
-
NMR, Crystallographic and Quantum Chemical Studies of Metalloproteins and Bisphosphonate Inhibitors
… thesis, we describe structural investigations of bisphosphonate drugs and their target enzyme, farnesyl diphosphate synthase (FPPS), using NMR, crystallography and computational techniques. The X-ray structures of nine bisphosphonates are reported together with their 31P solid-state NMR chemical …
-
Bone Mass Preservation and Fracture Risk Assessment with Bisphosphonate Therapy During Spaceflight
… success of the mission and postflight recovery. Bisphosphonates may be able to counteract this bone loss by altering the remodeling process. These drugs increase bone mass, thus reducing fracture risk, but also lead to increased levels of fatigue microdamage. Fracture risk can be lowered by …
-
Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
The broad, long-term objective of this research is to develop drug leads for new antibiotics, antiparasitics, and cancer chemotherapeutics. Two main areas of focus are inhibition of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and …
-
Stimulation humaner V-Gamma-9-V-Delta-2-T-Lymphozyten : Untersuchungen zur Wirkung Stickstoff-haltiger Bisphosphonate und zu bakteriellen Phosphoantigenen
… war die Charakterisierung der Erkennung von Bisphosphonaten durch Vg9Vd2-T-Zellen. Weder die Alkylmonophosphonate Ethyl- und Propylphosphonat noch 3-Aminopropylphosphonat bewirkten eine Stimulation von Vg9Vd2 T-Lymphozyten. Anscheinend ist also für die gd-T-Zell-stimulierende Aktivität von …
-
Association between Genetic Polymorphisms of Enzymes Involving Mevalonate Pathway(GGPS1 and FDPS) and Bone Mineral Density Response to Bisphosphonate Treatment
Geranylgeranyl diphosphate synthase1(GGPS1)과 farnesyl diphosphate synthase(FDPS)는 골다공증 치료제인 질소 함유 비스포스포네이트가 억제하는 표적효소로, 환자마다 비스포스포네이트에 대한 반응이 달리 나타나는 이유는 이 표적효소들의 유전자 다형성에서 기인하는 부분이 있을 것으로 생각된다. 본 연구의 목적은 GGPS1, FDPS 유전자에서 한국인 고유의 유전자 다형성을 찾고, 이에 따라 비스포스포네이트 투여에 대한 반응에 차이가 있는지를 평가하는 것이다. 골다공증 외에 …
-
Osteonecrosis of the jaw in association to bisphosphonates
The use of bisphosphonate has become more widespread for the treatment of bone metastasis, multiple myeloma, osteoporosis, Paget's disease and other bone malignancies. Osteonecrosis of the jaw (ONJ) has been recently recognized as a possible complication of the use of bisphosphonate therapy. This …
-
Modeling the Long Term Effects of Alendronate on Bone Mass Preservation of the Femur with Articular Surface and Total Hip Replacements
… Recently clinicians have been administering bisphosphonate drugs in an attempt to reduce the bone resorption due to stress shielding caused by these implants. Current strain-adaptive computational models with bisphosphonate treatment don’t predict the long term effects or look at treatment …
-
Comparison of Pharmacologic Treatment on Bone Mineral Density in Patients with Osteopenia
… was carried out to compare effectiveness of bisphosphonates and calcium and vitamin D supplements on bone mineral density in patients with osteopenia. METHOD: We evaluated the data of 94 patients who were diagnosed as having osteopenia with bone mineral densitometry in the health promotion …
-
Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
… inhibited by local treatment of the graft with a bisphosphonate. Our second hypothesis was that by adding bone-inductive BMP-7 to the bisphosphonate, new bone formation would also be stimulated, leading to an increase in stability. In papers I and II, the effect of the bisphosphonate zoledronate …
-
Bone mineral density changes after Total knee replacement in women over the age of 65
… on BMD differences one year after TKR. But bisphosphonate medication for 1 year prevent early reduction of hip BMD after TKR. This suggest bisphosphonate medication after TKR is beneficial to prevention of hip fracture.
-
Evaluation der Wirkung von Bisphosphonaten auf die Tumorangiogenese und ihre Bedeutung in der adjuvanten Tumortherapie
Bisphosphonate werden erfolgreich eingesetzt in der Therapie von Knochenerkrankungen und Skelettkomplikationen, verursacht durch Knochenmetastasen unterschiedlicher solider Tumorentitäten. Erste Daten deuten aber auch auf eine direkte antitumorale Aktivität dieser Substanzklasse hin. Der …
-
Alendronate treatment elicits a reduction in fatigue-life of canine cortical bone
… remodeling leads to osteoporotic fractures. Bisphosphonate drugs are proven to reduce fracture risk. However, the long-term effects of bisphosphonates on tissue-level properties are unknown. This study characterized the fatigue-life of cortical bone tissue after bisphosphonate treatment with …
-
INCIDENCE OF DENTAL IMPLANT FAILURE IN ACADEMIC SETTING - A CLINICAL RETROSPECTIVE STUDY PART ONE: PATIENT LEVEL
… on the chi-square test results, patients with bisphosphonate IV+PO (12%, P-value=0.004) were significantly overrepresented in the failure group. In contrast, patients with no bisphosphonate use (4.60%, P-value=0.004) were significantly underrepresented in the failure group. No …
-
Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach
… health threats to societies around the globe. Bisphosphonate drugs, long known for their ability to treat bone resorption diseases, have also served as the template for designing new agents against a variety of other diseases. In this work, computational modeling methods have been applied to …
-
Drug discovery against malaria parasite: drug repositioning strategy
… work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, in vitro high throughput screening, x-ray crystallography and other biophysical techniques. First, a computational method was developed …
-
SURFACE MODIFICATION OF TITANIUM AND TITANIUM ALLOYS TO ENHANCE BONE HEALING
… significantly, immobilization of drugs, such as, bisphosphonates, played an important role in enhancing the bone healing process. The main aim of the study is to develop and identify a facile surface modification method of immobilizing bisphosphonate molecules on commercially pure titanium and its …
-
Isoprenoid Biosynthesis Pathway as a Drug Target for Bisphosphonates: Transcriptional Profile Investigation
Bisphosphonates are known as potent inhibitors of the enzyme farnesyl diphosphate synthase (FPPS) and are clinically used to treat bone related disorders such as osteoporosis and bone cancer. Here we describe the development, testing and study of the mechanism of action of novel bisphosphonates as …
Page 1 of 3