Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"bioweapon"”.
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Examination of Antiviral Resistance in Venezuelan Equine Encephalitis Virus
… mosquitos, it can be aerosolized and used as a bioweapon. Unfortunately, there are currently no FDA-approved vaccines or antivirals against VEEV. Efforts have been made to discover small molecules with an inhibitory effect on VEEV, but the potential for emergence of antiviral resistance to these …
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Genetic factors that determine host resistance to bacterial infection
… a country’s national security, as the use of a bioweapon is an ever increasing concern. To help combat these threats, understanding how bacteria interact with their host could be a key research area. By understanding which human genes confer resistance or susceptibility to bacteria during …
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Glycan polymeric prodrugs against pulmonary intracellular alveolar infections
… of infection, and potential development as a bioweapon. Current antibiotics are limited by poor pharmacokinetic properties, and consequently require high frequency dosing at high concentrations to show promising clinical success. The physicochemical properties may also limit the route of …
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Interaction of Bacillus Anthracis Exosporium Protein Bcla With Complement Factor H and Spore Persistence In The Lung
… States and Europe and its potential use as a bioweapon have made <em>Bacillus anthracis</em> an interest of study. Anthrax infections are caused by the entry of <em>B. anthracis</em> spores into the host via the respiratory system, the gastrointestinal tract, cuts or wounds in the skin, and …
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Surface Polysaccharides of Francisella tularensis: Further Characterization, Role in Virulence, and Application to Novel Vaccine Strategies
… are considered Tier I Select Agents due to the bioweapon potential of these subspecies. Type A strains, considered the more virulent of the subspecies, are highly infective producing respiratory tularemia with inhalation of as few as 10 cells. Due to classification as a Select Agent, a vast …
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Utilizing Proteomic Techniques to Discover Host Protein Interactions with the E1 Glycoprotein of Venezuelan Equine Encephalitis Virus (VEEV) for Anti-Viral Discovery
… qualities drove interest in the pathogen as a bioweapon by the US and the former Soviet Union during the cold war. As a precautionary response to VEEV's notoriety as a biothreat, the National Institute of Allergies and Infectious Diseases has classified VEEV as a category B priority pathogen, …
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Interactions of Francisella Tularensis With Components of the Host Fibrinolytic System
<p><em>Francisella tularensis</em> (FT) is a Gram-negative coccobacillus and causative agent of a life-threatening disease commonly referred to as tularemia. Due to the highly infectious nature of the organism, its previous development as a biowarfare agent and its potential use in acts of …