Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"biotransport"”.
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Soluble factors and remodeling in a synthetic stem cell niche
… HSCs. The cell-cell interactions are mediated by biotransport of secreted soluble factors, which are in turn mediated by the biophysical properties of the matrix. This interdependence motivates a series of investigations to define the role of material properties on transport-mediated cell-cell …
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Stable Isotopes As Intrinsic Markers of Contaminant Dynamics in the Lake Winnipeg Food Web
… method for tracking habitat use and contaminant biotransport. Muscle of fishes and cormorants collected from Lake Winnipeg’s north basin were generally depleted in 13C and 34S but enriched in 15N relative to individuals from the south basin. Stable isotopic mixing models also revealed much of the …
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Characterization of Arterial Flow for Junctional Bleeding Control
<p>This study investigated reducing volumetric flowrate under steady flow conditions by varying lengths of compression with constant cross-sectional area and varying cross-sectional area reduction with constant length in order to better understand how to control junctional hemorrhaging. The …
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Modeling the Long Term Effects of Alendronate on Bone Mass Preservation of the Femur with Articular Surface and Total Hip Replacements
Calculating femoral bone density changes after hip arthroplasty is of interest to researchers and clinicians for predicting the longevity of the prosthetic implant and the surrounding bone. Recently clinicians have been administering bisphosphonate drugs in an attempt to reduce the bone resorption …
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Theory for diffusional encounters in heterogeneous environments and multivalent electrolyte screening of charged interface
<p>We develop a theory for encounter rates in a three-dimensional system of connected compartments. The model of connected compartments exhibits the length-scale dependent diffusion that is observed in many heterogeneous environments, such as porous catalysts and biological environments. We …
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A three constituent mixture theory model of cutaneous and subcutaneous tissue in the context of neonatal pressure ulcer etiology and prevention
<p>Localized ischemia, impaired interstitial fluid flow, and sustained mechanical loading of cells have all been hypothesized as mechanisms of pressure ulcer (PrU) etiology. Time-varying loading has experimentally been shown to increase fluid flow in human skin <em>in vivo.</em> Towards the design …
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Understanding preferred leg stiffness and layered control strategies for locomotion
<p>Despite advancement in the field of robotics, current legged robots still cannot achieve the kind of locomotion stability animals and humans have. In order to develop legged robots with greater stability, we need to better understand general locomotion dynamics and control principles. Here we …
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Unveiling the mechanical behavior of the rod-like microstructure in the radular teeth of cryptochiton stelleri
<p>Natural ceramics provided with high volume fractions of mineralized materials that are surrounded by a weak organic interface combine the stiff mechanical behavior of building blocks, like hydroxyapatite or aragonite, and the compliance of the organic surroundings. Unique mechanical properties …
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Dislocation Mechanics of Total Hip Arthroplasty: A Combined Experimental and Computational Analysis
<p>While total hip arthroplasty is considered a successful procedure, dislocation remains a serious complication as recurrent dislocations may require additional surgeries. Knowledge on dislocation events as they occur in vivo are limited, therefore researchers rely on experimental and …
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Specimen-Specific Natural, Pathological, and Implanted Knee Mechanics Using Finite Element Modeling
<p>There is an increasing incidence of knee pain and injury among the population, and increasing demand for higher knee function in total knee replacement designs. As a result, clinicians and implant manufacturers are interested in improving patient outcomes, and evaluation of knee mechanics is …
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Inverse Dynamic Analysis of ACL Reconstructed Knee Joint Biomechanics During Gait and Cycling Using OpenSim
<p>ACL (anterior cruciate ligament) injuries of the knee joint alter biomechanics and may cause abnormal loading conditions that place patients at a higher risk of developing osteoarthritis (OA). There are multiple types of ACL reconstruction (ACLR), but all types aim to restore anterior tibial …
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Mechanical Properties of Bone Due to SOST Expression: A 3-Point Bending Assessment of Murine Femurs
<p>Sclerostin, a protein coded for by the SOST gene, is an osteocyte-expressed negative regulator of bone formation. The absence of SOST in the genome may have an effect on bone formation both during skeletal maturation and full maturity. This study attempts to determine significant differences in …
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A 2-D Analysis of Strains at the Interface Between the Brain and the Skull
<p>Rapid deformation of brain tissue caused by skull acceleration is one of the most significant causes of traumatic brain injury (TBI). Although the deformation mechanisms within the brain have been revealed by analysis of tagged magnetic resonance images, the mechanical responses at the periphery …
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Assessment of material properties in bone surrounding microdamage
<p> Bisphosphonates [BPs] are the mainstay for osteoporosis treatment. They suppress bone resorption/remodeling, preventing bone loss. However, BPs also suppress the beneficial bone remodeling that replaces microscopically damaged bone that occurs from normal mechanical wear-and-tear or fatigue, …
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Quantitative In Vitro Characterization of Membrane Permeability for Electroporated Mammalian Cells
Electroporation-based treatments are motivated by the response of biological membranes to high- intensity pulsed electric fields. These fields rearrange the membrane structure to enhance the membrane's diffusive permeability, or the degree to which a membrane allows molecules to diffuse through it, …
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Intranuclear strain measured by iterative warping in cells under mechanical and osmotic stress
<p>The nucleus is a membrane bound organelle and regulation center for gene expression in the cell. Mechanical forces transfer to the nucleus directly and indirectly through specific cellular cytoskeletal structures and pathways. There is increasing evidence that the transferred forces to the …
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Restoration of Bone Material and Microstructural Properties after Long-Term Remodeling Suppression
<p>Anti-resorptive drugs, principally bisphosphonates (BPs), are the mainstay of osteoporosis treatment. They work by inhibiting bone resorption/remodeling, thus preventing bone loss. However, long-term suppression of bone resorption adversely affects bone tissue mechanical properties, even while …
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Diffuse Damage Repair Mechanism in Bone
<p>Bone microdamage is a result of fatigue, creep or ‘wear and tear’ caused by physiological activities and largely contributes to bone fragility. Bone, unlike engineered materials, has the ability to repair the microscopic cracking or microdamage through targeted, osteoclast-mediated bone …
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Youth Pitching Kinematics: Associations with Body Overweight Parameters
<p>The objective of this study was to investigate associations between injury-related kinematic parameters and overweight measures for youth baseball pitchers. The injury-related kinematic parameters considered were measurements 1) at foot contact: stride length, front foot position, shoulder …
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