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Showing 1 to 8 of 8 for “"biotin synthesis"”.
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Biotin synthesis in Escherichia coli
Biotin is an essential enzyme cofactor required by all three domains of life. It functions as a covalently-bound prosthetic group, which mediates the transport of CO2 in many vital metabolic carboxylation, decarboxylation and transcarboxylation reactions. Although biotin is essential, our knowledge …
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Biotin synthesis in α-proteobacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Biotin synthesis in Bacillus subtilis
Biotin is a cofactor required by all three domains of life. It is an enzyme cofactor that acts as a “swinging arm” to transfer carboxyl groups in important metabolic pathways involving carboxylation, decarboxylation and transcarboxylation reactions. Despite its importance, the biotin biosynthetic …
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Fatty Acid and Biotin Metabolism in Escherichia Coli
Biotin which is essential for the synthesis of fatty acids in E. coli is thought to be derived from a modified fatty acid pathway. In experiments used to verify this hypothesis I discovered a new intermediate in biotin synthesis. This intermediate `X', was purified from the spent growth medium of …
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Studies of lipoic acid and biotin metabolism in bacteria and higher eukaryotes
… focus has been the study of lipoic acid and biotin metabolism in several bacteria. Lipoic acid and biotin are essential enzyme cofactors found in all three domains of life. Both molecules function only when covalently attached to key metabolic enzymes, 2-oxoacid dehygrogenase (OADH) and …
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The synthesis, regulation and function of biotin in bacteria
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Transcriptional regulation and enzymatic functions of the Escherichia coli biotin protein ligase
Biotin metabolism in prokaryotes is directly linked to transcriptional regulation by the enzyme biotin protein ligase (BPL). This system is most thoroughly studied and characterized in Escherichia coli. Transcription of the E. coli biotin (bio) operon is directly regulated by the biotin-protein …
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Regulatory function and interdomain communication of group II biotin protein ligases
Biotin is a cofactor required for function of essential biotin dependent enzymes that are involved in metabolic processes including fatty acid biosynthesis, gluconeogenesis, and amino acid catabolism. In order for biotin to act as a cofactor it must first be covalently attached to the biotin …