Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"biotherapeutic"”.
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Functional DNA Aptamers as Biotherapeutic Molecules
Aptamers are single-stranded oligonucleotides, DNA or RNA, which can bind to a myriad of targets such as ions, peptides, proteins, drugs, organic and inorganic molecules with high affinity and specificity. Aptamers are derived using combinatorial libraries comprised of a variable region flanked by …
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Microneedle-mediated transdermal drug delivery of biotherapeutic macromolecules
In the last 20 years biotherapeutic macromolecules have become the fastest growing sector within pharmaceutical industry. Their development, facilitated by the introduction of advanced molecular engineering techniques, has led to improved treatment options for patients with autoimmune conditions, …
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Antibody drug discovery: From Idea to Biotherapeutic Molecule
… responsible for early stage drug development of biotherapeutic molecules. Part of this responsibility is delivering high quality molecules while meeting tight deadlines. Across the industry there is constant pressure to decrease timelines, while at the same time the complexity of molecules is …
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Thermal analysis of biochemical systems
… and are taken orally and 2) large molecule, biotherapeutic, or protein-based drugs, which are often synthesized via ribosome transcription in bacteria cells and are injected. Historically, the majority of drug development, revenue, and products has come from small molecule drugs. However, …
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Polymeric nanoparticle as a new platform for high removal of endotoxins from biopharmaceutical solutions
… are much cheaper to cultivate and provide higher biotherapeutic yield compared to mammalian cells. On extracting the useful biotherapeutics from the gram-negative bacterial cells (<em>E.coli</em>), endotoxin present in the bacteria is released in the surrounding media thus contaminating the …
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A platelet-mediated paradigm for the targeted delivery of microencapsulated, clot-augmenting biotherapeutics
… controlled “burst” release of an encapsulated biotherapeutics. As platelets are the “first responders” in the blood clot formation process, this platelet-hybridized system is ideal for the targeted delivery of clot augmenting biotherapeutics wherein immediate therapeutic efficacy is required. …
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The Development of Methods for Generating Fc-Conjugates and Antibody-Drug Conjugates
Biotherapeutics, such as peptides and proteins, constitute a valuable class of drugs due to their high target specificity and their ability to modulate protein interactions (PPIs), which are often considered ‘undruggable’ by traditional small molecule drugs. Additionally, antibodies possess many …
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Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering
… by exogenous proteases; this schema has biotherapeutic potential, as demonstrated by zymogens which activate in response to viral infection and exert cytotoxic ribonucleolytic activity. Efforts to establish a zymogen directed toward the coronavirus SARS-CoV-2 are described in two parts of …
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Evaluation of dynamic light scattering as a technique for the routine monitoring of therapeutic proteins on stability
Throughout the course of biotherapeutic development and manufacturing, the detection and quantification of protein aggregates and particles is critical to ensure patient safety. Size Exclusion Chromatography (SEC) is one of the most widely used techniques for the separation of proteins and allows …
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Optimisation of CHO Cell Line Development Using Hybrid Modelling for Antibody Therapeutics
… particularly for personalised medicines and biotherapeutics, which hold the potential to be the safest and most effective therapeutic of all [1, 2]. Herein I propose a novel method for optimising upstream biopharmaceutical process scaling up using a data-driven hybrid model that integrates …
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The Development of a Tumour-Responsive Format for Antibody Conjugates
Antibody-drug conjugates (ADCs) are an emerging class of targeted therapeutics which exploit the selectivity of monoclonal antibodies towards particular membrane receptors, to deliver potent cytotoxins to a desired cell type. A significant amount of research has been undertaken to improve the …
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La microbiota humana como estrategia farmacológica en el entorno regulatorio europeo.
… terapéuticos basados en microorganismos (Live Biotherapeutic Products o LBP) dado su alto potencial clínico-terapéutico. En estos actores la mayor incertidumbre emana de los aspectos meramente científico-técnicos por sus especiales características y sus diferencias con cualquier otro fármaco …
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Exploring early-life microbiome transfer and therapeutic applications in bovines and humans
… efficacy of emulsion based postbiotic and live-biotherapeutic formulations of Lactococcus lactis DPC3147, producer of the bacteriocin lacticin 3147, as alternative therapeutics for bovine mastitis. Twenty eight cows with chronic mastitis were treated with emulsion-based formulations containing …