Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"biotechnology industry"”.
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Capital project development in biotechnology industry
The biotechnology industry has experienced fast growth during the first 30 years of its existence but is now reaching a stage of maturity. Companies are being challenged by weak pipelines and patent expirations, as well as increasing regulation. Mergers and acquisitions are frequent, and companies …
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The venture capital in the biotechnology industry
The Biotechnology investment sector has been booming over the last ten years delivering substantial financial returns for public and private investors and most VC firms have been raising and deploying a lot of capital into fast-growing Biotechnology companies. However, it may seem paradoxical that …
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A system dynamics investigation of sustainable growth in the biotechnology industry
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
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Economic development challenges in the City of Cambridge : the biotechnology industry
… abundant resources, some firms in the hi-growth biotechnologyI sector have either left Cambridge 2 or, are considering leaving the City. The reasons why new biotechnology firms locate in Cambridge are well understood and conform to prevailing location theories; A highly skilled and educated labor …
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Determinants of location and competitiveness in the biotechnology industry : the case of Massachusetts
Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1993.
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The Determinants of Organizational Form in the Biotechnology Industry: An Integrative Organizational Economics Framework
… of equity investment in the pharmaceutical-biotechnology alliances in this sample suggests that investments are not made so much for equity participation, but as a financing method, and possibly as a signal of commitment. Lastly, the informal mechanisms seem to be byproducts of doing …
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The role of biotechnology training partnerships in expanding local employment opportunities for community college graduates in California's biotechnology industry
… intermediaries in a knowledge-intensive industry expand employment opportunities for a nontraditional, i.e., less-educated or displaced workforce. Specifically, it investigated the recruitment and hiring practices for entry-level biomanufacturing and biological technicians among a sample …
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The evaluation of system-wide financial incentives in pipeline decisions in the pharmaceutical and biotechnology industry : the paradox of R&D spend Vs. new drug approvals
… environment, the basic economic model of the industry is now being questioned. In this work I review the recent financial performance of ten major global pharmaceutical companies, and the challenges faced by the industry in moving from a deterministic, blockbuster era to a more stochastic era …
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Essays on Intellectual Property Protection and Innovation in Agriculture
… rate of technical changes in the agricultural biotechnology industry. Results from this essay imply that innovation networks in agricultural biotechnology are rather undifferentiated, in which various inventors take advantage of the diffusion of knowledge facilitated by patents. Further, such a …
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An analysis of the role of government in the locational decisions of Cambridge biotechnology firms
… the locational decisions of firms in Cambridge's biotechnology industry, the impact of the state sector in the evolution of a critically important knowledge-intensive industry is explored. Interviews, surveys, and geographical analysis were conducted to evaluate the author's hypothesis. The answer …
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Understanding social amplification of risk : possible impact of an avian flu pandemic
… a pandemic may cause. For the pharmaceutical/biotechnology industry, the major concerns of a pandemic include high employee absentee rates, lack of accessibility to the medical facilities, and disruption to the product supply chain. This work introduces social amplification of risk theory to …
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Commercialization strategies of biotechnology companies
In the biotechnology industry today, there are many business models for project commercialization. These models range from independent vertical integration to certain forms of collaboration with pharmaceutical companies to complete acquisitions of projects by the big pharmaceutical companies. In …
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Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
… have been plaguing the pharmaceutical and biotechnology industries. Amgen has felt the effects of these forces and launched a new effort to improve its operations via continuous improvement and Lean, ultimately reducing costs and improving productivity of operations. This thesis examines …
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The extraction of Cytochrome C and DsRed2 into reverse micelles
… primary separation step for the recombinant biotechnology industry. However, each process will have to be optimized to the protein of interest, as protein extraction is specific to certain properties and is extremely sensitive.
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Comparison of the growth and monoclonal antibody production of suspended mammalian cells in three perfusion systems
… for typical drug production vehicles in the biotechnology industry. This goal was accomplished by comparing the growth and monoclonal antibody production by HPCHO Chinese hamster ovary cells and IB4 hybridoma cells in batch, fed-batch, and three perfusion systems: the stirred ceramic membrane …
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A network planning process and inventory strategy for high-mix low-volume markets
… leading human therapeutics companies in the biotechnology industry - was investigated and a strategy was developed to mitigate the major challenges associated with globalization. Amgen is transitioning from predominantly high-volume low-mix manufacturing and a "one size fits all" Operations …
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Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large-scale production bioreactors (15,000L), but process development occurs in lab-scale production bioreactors (2-3L). Cell culture processes are complicated and the scale-up from bench-scale to commercial-scale …
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Process Analytical Technology in biopharmaceutical manufacturing
… a well-defined concept within the pharmaceutical industry as a result of a major initiative by the FDA called "Pharmaceutical cGMPs for the 21st Century: A Risk-Based Approach." The FDA defines PAT as "a system for designing, analyzing, and controlling manufacturing through timely measurements …
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Feasibility study of Korea biocluster with real estate perspectives
… changing environment. For example, many global biotechnology firms are seeking new geographical locations as part of their strategy to expand their business. Korea's biotechnology reputation and prospects as a potential site for biotech businesses is attracting increase attention. The Yeongjong …
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Building a biomedical cluster : a comparative study of MIT and Singapore
… its role in the development of the biomedical industry cluster in Cambridge, Massachusetts. However, while the important role that academic institutions play in the process of transforming science to marketable technology is acknowledged, the question of who are the actual researchers most …
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