Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"biosynthetic engineering"”.
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Biosynthetic engineering of plantazolicin natural products
… to thiazoles and (methyl)oxazoles. The final biosynthetic steps consist of leader peptide removal and dimethylation of the nascent N-terminus. To simultaneously establish the structure-activity relationship of PZN and the substrate tolerance of the biosynthetic pathway, an Escherichia coli …
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Biosynthetic engineering for the assembly of better drugs
… of genetic approaches to decipher the biosynthetic code that guides the assembly of several natural product families have revealed that living systems methodically and repetitively combine carbohydrate-derived building blocks in metabolic unit reactions to generate unprecedented …
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Chemical and chemoenzymatic syntheses of lantibiotics and other bioactive cyclic peptides
… in Chapter II, the activity of an engineered biosynthetic enzyme involved in lacticin 481 maturation was reconstituted in vitro and used to produce a panel of lacticin 481 analogues from synthetic precursor peptides, several of which possessed improved antibacterial potency. This enhanced …