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Showing 1 to 20 of 765 for “"biosynthetic"”.
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The biosynthetic Claisen condensation : mechanistic enzymology of biosynthetic thiolase from Zoogloea ramigera
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1987.
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Biosynthetic Studies on Pactamycin
Pactamycin (1), a cytotoxic antibiotic produced by Streptomyces pactum, var. pactum, contains several interesting structural features, including a cyclopentanoid ring, which is rare among natural products, a 6-methylsalicylic acid (6-MSA) unit derived from acetate via a polyketide route, and a …
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Biosynthetic Studies on the Neomycins
Made available in DSpace on 2014-12-05T19:38:19Z (GMT). No. of bitstreams: 1 6402884.pdf: 5870519 bytes, checksum: 664da4bf54c90fd75cb1cee04824d3fe (MD5) Previous issue date: 1963
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Biosynthetic engineering of plantazolicin natural products
… to thiazoles and (methyl)oxazoles. The final biosynthetic steps consist of leader peptide removal and dimethylation of the nascent N-terminus. To simultaneously establish the structure-activity relationship of PZN and the substrate tolerance of the biosynthetic pathway, an Escherichia coli …
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Biosynthetic Studies on Geldanamycin and Pactamycin
The formation of the m-C(,7)N units of geldanamycin and pactamycin via the shikimate pathway was studied. {('13)C(,6)}glucose was used to determine the incorporation of intact carbon units into both molecules. This revealed that the respective m-C(,7)N units were derived from three-carbon and …
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Biosynthetic and Mutasynthetic Studies of Neomycin
Made available in DSpace on 2014-12-13T20:10:23Z (GMT). No. of bitstreams: 1 7811285.pdf: 5372000 bytes, checksum: 94ce34fb8a88a909a5daa936231f4989 (MD5) Previous issue date: 1977
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Investigation of class v lanthipeptide biosynthetic pathway
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Genome Mining for Actinomycete Biosynthetic Gene Clusters
… procedures for analysing and manipulating the biosynthetic pathway. In this work, three strains have been studied that address different aspects of this challenge. Streptomyces sp. DSM4137 is a genetically amenable strain and a notably prolific producer of diverse natural products, but also has …
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Synthesis of Mycobacterial Ergothioneine biosynthetic pathway metabolites
… the synthesis of the EgtE enzyme substrate, ESH biosynthetic precursor, R- and S-(β-amino-β-carboxyethyl) ergothioneine sulfoxide. In order to prove that synthesized compounds are indeed mycobacterium ESH pathway enzyme substrates, crude M. smeg cell free lysate enzyme was used to convert …
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Regulation of The Candida Albicans Arginine Biosynthetic Pathway
… The strong upregulation of the arginine biosynthetic (<em>ARG</em>) genes suggests their importancefor <em>C. albicans </em>virulence.</p> <p>Using single cell reporters I have shown that the (<em>ARG</em>) genes are induced specifically upon <em>C. albicans</em> phagocytosis in response …
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Elucidation of the Biosynthetic Pathway for 7-Deazapurines
… of GTP to the previously identified queuosine biosynthetic intermediate 7-cyano-7-deazaguanine (preQ₀) is demonstrated using purified, recombinant enzymes. Also included herein is a kinetic, spectroscopic, and mechanistic characterization of QueE, an enzyme that catalyzes the third step in the …
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Biosynthetic and structural studies of neomycin and berninamycin
($\sp{13}$C$\sb6$) Glucose (3) was supplemented to seven-days old resting cells of neomycin B-proucing S.fradiae. The $\sp{13}$C NMR spectra of the enriched neomycin B (2) showed complex coupling patterns which suggested that 3 is not incorporated as an intact C$\sb6$ unit into the carbon skeleton …
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Algorithmic discovery and characterization of new biosynthetic reactions
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Biosynthetic engineering for the assembly of better drugs
… of genetic approaches to decipher the biosynthetic code that guides the assembly of several natural product families have revealed that living systems methodically and repetitively combine carbohydrate-derived building blocks in metabolic unit reactions to generate unprecedented …
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Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroline-5-carboxylate (P5C) to proline. Mutations in the PYCR1 gene alter …
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