Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"biospecimens"”.
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Informed consent and the secondary use of biospecimens in oncology research legal and bioethics perspectives
Biospecimens1 collected during routine oncology diagnostic and therapeutic interventions may be stored for future medical purposes. In accordance with legal and ethical principles, the patient provides informed consent for removal of the tissue for diagnostic or therapeutic reasons. Informed …
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Designing a state-of-the-science, accredited, commercially-successful biorepository utilizing ISO:9001(2008) quality management system requirements to construct the framework
… needs, ensure high quality, fit-for-purpose biospecimens, and, most importantly, protect and preserve the biospecimens entrusted to its care.</p>
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Biobank for America
More than 300 million biospecimens - blood samples, saliva swabs, excised tumors - are housed in different collections all over the country right now. Meanwhile, biometric data is constantly being compiled by sophisticated security systems, by lifestyle products, and even by ordinary ATMs. Because …
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Investigating kidney disease clinical epidemiology using routinely collected administrative data and proteomics
… during healthcare visits and additional biospecimens collected as part of cohort study activities are invaluable to better understand kidney disease epidemiology. This thesis explores the detection and characterization of acute kidney injury (AKI), chronic kidney disease (CKD), …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… significance of these results,we used human PDAC biospecimens to examine the effects of EUS-RFA in conjunction with chemotherapy in theneoadjuvant setting. An increase in apoptotic cell death as measured by cleaved caspase-3 expression, significant increase in collagen deposition, a decrease in …
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Identification of Lung Carcinoma Biomarkers Associated with Tumour Development and Drug Resistance
… pathways. The molecular analysis of a variety of biospecimens has allowed the discovery of relevant candidate biomarkers and consequently the identification of novel proteins that may have a role in the development of lung cancer and establishment of drug resistance. There is a need for …
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Multi-omics approaches for diagnosis, prognosis and response to treatment of colorectal cancer.
… status) investigated in different types of biospecimens from the same subjects (stool, plasma, primary tissue) for the diagnosis and prognosis of patients with CRC, identifying specific signatures. Samples collected from patients with diagnosis of CRC, recruited in our outpatient clinic and …
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Topic Model-based Mass Spectrometric Data Analysis in Cancer Biomarker Discovery Studies
… is owing to the heterogeneous nature of human biospecimens. Although this issue has been a subject of discussion in cancer genomic studies, it has not yet been rigorously investigated in mass spectrometry based omic studies. Purification of mass spectometric data is highly desired prior to …
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Inflammatory Biomarkers, Genetics, and Survival among Colorectal Cancer Patients
… aims, we first leveraged the existing data and biospecimens from the Seattle Colon Cancer Family Registry Cohort (SCCFR) and collected data on measures of all five circulating inflammatory biomarkers using stored plasma samples. Hazards ratios for circulating inflammation biomarkers were …
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Investigating Private Drinking Water Quality and Biomarkers of Associated Health Outcomes in Southwest Virginia
Approximately 1.8 million Americans living in rural communities do not have access to safely managed household drinking water. Recent research has demonstrated high rates of the US Environmental Protection Agency's (EPA) Safe Drinking Water Act (SDWA) violations in rural areas and heavy dependence …