Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"biorelevant"”.
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… PhD project aimed to advance the development of biorelevant in vitro testing strategies for complex drug delivery systems intended for parenteral administration, as well as for innovative oral formulations. The first part of the work focused on the subcutaneous tissue, evaluating current …
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A 'Biorelevant' Approach for Accelerated In Vitro Release and In Vitro-In Vivo Relationship of a Biodegradable, Naltrexone Implant
… Balanced Salts Solution was characterized as a 'biorelevant' medium for in vitro drug release studies. Naltrexone was found to be sufficiently stable in the medium, as determined by a stability-indicating High Performance Liquid Chromatography (HPLC) assay. A miniature, cell-culture, capillary …
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Synthesis, Characterization and Cellular Uptake of Magnesium Complexes of Pyrones and Amino Acids
… solid-state characterization of "pharma grade", biorelevant magnesium complexes (nutraceuticals) utilizing short-chain peptides (di- and tri-), pyrones, and amino acids. There is further emphasis placed on determining the in vitro uptake of all produced complexes. This work aims to mitigate the …
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Exploring the utility of the pig model for predicting bioavailability in humans
… acid content. Based on the findings a porcine biorelevant media (FaSSIFp) was proposed. Porcine GI transit conditions were studied with a telemetric motility capsule (SmartPill®) under fasted and postprandial conditions, by determining pH values, pressure and temperature. The physiological GI …
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IN VITRO IN VIVO METHODS AND PHARMACOKINETIC MODELS FOR SUBCUTANEOUSLY ADMINISTERED PEPTIDE DRUG PRODUCTS
… immediate release (IR) peptide based drugs in a biorelevant manner. The contribution of IVIVC in drug development of orally administered drugs is very well known. For oral drugs, the in vivo process of drug absorption is often rate limited by the rate at which drug dissolves in the …
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In vitro and in silico profiling to assist pharmaceutical development
… vitro solubility of poorly soluble drugs. A new biorelevant medium simulating the fasted and fed intestinal states was developed to examine the feasibility of merging the individual fasted and fed studies into one single experiment. The purpose was to forecast the parameters influencing …
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Biomolecularly and mechanically instructive materials for guiding cell-substrate interactions
… This strategy can be used on a variety of biorelevant substrates to replicate the properties of the native extracellular matrix. Our results shed light on the combinatorial influence of multiple cues and have the potential to identify key parameters to specifically alter cell response with …
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Computational pharmaceutics approaches to inform drug developability: focus on lipid-based formulations
… completed using these fluids, where in vitro biorelevant dispersion screening with SEDDS using various dilution conditions was compared to the ex vivo results. Results: Firstly, this thesis demonstrated the applicability of ML for the prediction of a quality target product profile …
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Biomarkers: Implications from Discovery and the development of Microscale Electrochemical Sensing Techniques for Their Detection
… and environment in question. Discovery at the biorelevant level of microns and nanometers requires tools with exceptional sensitivity, selectivity, and repeatability. Among the available methodologies, electrochemical sensing techniques occupy a unique place given their well-understood …
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… excipients. These investigations incorporated biorelevant dissolution testing, multivariate data modelling, solid-state and thermal analyses, as well as particle size characterization. The first major finding of this thesis was the development of a predictive model to quantify the dissolution …
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Novel Poly(N-substituted glycine)s : synthesis, post-modification, and physical properties
Various synthetic approaches were explored towards the preparation of poly(N-substituted glycine) homo/co-polymers (a.k.a. polypeptoids). In particular, monomers that would facilitate in the preparation of bio-relevant polymers via either chain- or step-growth polymerization were targeted. A 3-step …
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Complex bioactive fiber systems by means of electrospinning
… with calcium carbonate or calcium phosphate, two biorelevant minerals. Such composite structures are attractive for the potential improvement of properties such as stiffness or bioactivity. It was possible to encapsulate nano and mixed sized plasma-treated PCL meshes to areas > 1 mm2 with calcium …
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Assessing the impact of tablet crushing, dose, and high-calorie, high-fat meal on vericiguat absorption from the upper gastrointestinal lumen using standardized commercially available equipment and materials
… σε θερμίδες και λίπη στον ανώτερο εντερικό αυλό (biorelevant gastrointestinal transfer system after high-calorie, high-fat meal, BioGIThighcal) χρησιμοποιώντας εμπορικά διαθέσιμα όργανα και υλικά. (2) Με βάση τα επίπεδα του vericiguat που μετρήθηκαν στο παρελθόν στο πλάσμα υγιών ενηλίκων, να …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
… conditions of the skin, proposed is the use of a biorelevant artificial interstitial fluid as the in vitro release medium for both MAP formulations, supplemented with a non-ionic surfactant to maintain sink conditions for lipophilic LOR. Additionally, evaluation of skin models revealed that …
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SIDEROPHORE DESFERRIOXAMINE B PROMOTED DISSOLUTION AND ADSORPTION PROPERTIES OF TITANIUM DIOXIDE BEARING MINERALS
… potential dissolution and transformation in biorelevant conditions.Transition metals like iron are considered an essential element for many microorganisms and especially for marine and terrestrial systems. However, their bioavailability is restricted due to the low solubility of Fe(III) in …