Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"bioprocessing"”.
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Characterisation of chromatography adsorbents for antibody bioprocessing
Currently the purification of monoclonal antibodies for therapeutic purposes is reliant on protein A affinity chromatography. The rapid growth of this class of therapeutic and their high value makes the understanding of protein A chromatography an important target. There is a range of commercially …
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Neural Networks in Bioprocessing and Chemical Engineering
… networks, focusing on their applications in bioprocessing and chemical engineering. This study introduces neural networks and provides an overview of their structures, strengths, and limitations, together with a survey of their potential and commercial applications (Chapter 1). In addition to …
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The Biological Impact of High Throughput Continuous Bioprocessing
… control strategy for perfusion equips the bioprocessing industry to explore the benefits of perfusion culture to meet increasing global demand for mAbs.
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Centrifugal recovery of embryonic stem cells for regenerative medicine bioprocessing
… medicine applications to examine the bioprocessing impact of centrifugal recovery cells. A micro scale-down approach was used to examine the e�ffects of centrifugal force, centrifugation time and process temperature on both the yield and biological characteristics of cells subjected to …
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Increasing the Nutritional Value of Canola Meal via Fungal Bioprocessing
<p>The main limitation of meals from canola and other <em>Brassica </em>spp. is the presence of glucosinolates (GLS), which are anti-nutritional and can even be toxic at high ingestion levels. Furthermore, large amounts of GLS can reduce palatability for livestock and thus reduce intake and growth …
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Developing Serum-Free Media Via Bioprocessing For Cultivated Seafood Products
Global food production management has become a challenge with an anticipated population of 10 billion people by 2050 and the ongoing COVID-19 epidemic. Seafood is a vital food source due to its widespread consumption, excellent nutrient profile, and low feed conversion ratio, rendering its …
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Machine Learning and Multivariate Statistics for Optimizing Bioprocessing and Polyolefin Manufacturing
… of ensemble-based machine learning methods in bioprocessing, particularly for the prediction of different fermenter types in a fermentation process (to allow for successful data integration) and the prediction of the onset of foaming. We apply two ensemble frameworks, Extreme Gradient Boosting …
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Oxidative stress and nitrosative stress, their interaction and implications for bioprocessing
The present study focuses on a series of physiological studies to study oxidative and nitrosative stress and online monitoring of fungal biomass growth in submerged batch cultures of the filamentous fungus Aspergillus niger B1-D, modified to secrete lysozyme. The results of the undertaken studies …
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Studies on cell disruption and cell debris removal in downstream bioprocessing
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1989.
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An Analysis Of The Impact Of Storage Temperature, Moisture Content & Duration Upon The Chemical Components & Bioprocessing Of Lignocellulosic Biomass
<p>The successful utilization of lignocellulosic biomass as a feedstock for fuels and chemicals necessitates storage for 2-6 months. It is correspondingly important to understand the impact of storage parameters - moisture concentration, temperature and duration - on biomass quality.</p> <p>As …
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New approaches to real time monitoring of bio-manufacturing processes
Over the past decade the bioprocessing industry has embraced and led the creation of a number of initiatives to drive process development and optimisation. There has consequently been an increased demand for tools capable of meeting the requirements of these initiatives. Spectroscopic monitoring …
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Utilization of Soybean Products as Fish-Meal Protein Replacements in Yellow Perch Perca flavescens Feeds
… success. Novel soy ingredients created through bioprocessing technology potentially provide more highly digestible nutrients with fewer anti-nutritional factors (ANFs) than traditionally processed soy products. To examine the utility of certain bioprocessing technologies, ingredient compositions …
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Application of MRI and low-field NMR in biopharmaceutical development
… Understanding the processes involved in upstream bioprocessing, where mAbs are manufactured by cells, is therefore paramount. To date, nuclear magnetic resonance (NMR) has had limited application in upstream bioprocessing, stemming from the use of high-field NMR systems that require large capital …
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Enabling Cl-Based bioconversion with metabolic engineering
… food supply. However, their use in industrial bioprocessing remains limited, primarily because microbes that utilize these substrates are poorly characterized biochemically, and limited tools exist for their genetic modification. This leaves the metabolic engineer with a choice: to develop …
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Improvement of a cell-based test system for the biological assessment of plastics for use in single-use bioreactors
The application of Single-Use (SU) bioprocessing technology in the biopharmaceutical market is fully established due to their manifold advantages. Therefore, the demand for biocompatible SU materials is increasing to ensure consistent cell growth and patient safety. Biocompatibility must be …
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Altering an Epoxy-Amine Thermoset's Performance Through Varying Mix Ratios
… prescribed recommendations. When manufacturing bioprocessing products for the medical field, a company is under a limited capacity to change materials of construct. Determining how to modify the processing conditions in order to control the material properties of an epoxy would benefit …
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Carbon Catabolite Repression Relaxation: Approaches for Sugar Co-Utilization in Escherichia coli
Bioprocessing provides a sustainable, renewable, and green alternative to petroleum-based methods for the production of chemicals. A primary reason for the benefit of bioprocessing is its ability to utilize waste materials containing sugars as a feedstock, such as those from agriculture. This …
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Design and Fabrication of Piezoelectric Sensors and Actuators for Characterization of Soft Materials
… biosensors in practical biomanufacturing and bioprocessing formats, as insight into a material's composition (i.e., concentration of a given biologic within a material or product) provides molecular-scale insight into processes and product quality. The second objective was to design, …
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The effect of non-biological particulates on microbial cell disruption in a slurry bioreactor
… particles are used, include bead mills, minerals bioprocessing, soil bioremediation and immobilised biocatalysts. An understanding of the rate, extent and mechanisms of cell disruption in these systems will facilitate the design of bioreactors to minimise or maximise microbial cell disruption, …
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