Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 230 for “"bioprocess"”.
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Microbioreactors for bioprocess development
… and actuators as a step towards high-throughput bioprocess development. In particular, this thesis demonstrates the feasibility of culturing microbial cells in microliter-volume reactors in batch, continuous, fed-batch operations. The microbioreactor is fabricated out of poly(methylmethacrylate) …
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Data reconciliation in bioprocess development
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1997.
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Advanced Raman spectroscopy for bioprocess monitoring
… the lack of sensitivity of conventional Raman in bioprocess applications, the major drawback of this technique so far has been the disturbance of the broad fluorescence background especially in biological samples. The main objective of this thesis was to find solutions for increasing the limit of …
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Online Raman spectroscopy for bioprocess monitoring
Online monitoring of bioprocesses is essential to expanding the potential of biotechnology. In this thesis, a system to estimate concentrations of chemical components of an Escherichia Coli fermentation growth medium via a remote fiber-optic Raman spectroscopy probe was studied in depth. The system …
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Developing Magnetic Resonance Based Analytics to Support Continuous Bioprocess
This thesis presents the development and implementation of magnetic resonance techniques to study biopharmaceutical samples, specifically from upstream bioreactors. The motivation for this research is to improve our ability to produce therapeutic proteins of appropriate quality and quantity. The …
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Modelling and simulation based assessment in sustainable bioprocess development
… the present study, such a simplified approach to bioprocess design is demonstrated using a case study for the large-scale production of citric acid.
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Tradespace as a decision making tool in bioprocess design
… (DoE) and applied for the first time to a bioprocess design problem. The implementation of DoE was necessary due to the high complexity of bioprocess systems, where a design variable (or a reasonably small number of design variables) cannot be easily identified to explain a given attribute …
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Development of a regenerable glucose biosensor probe for bioprocess monitoring
… of enzyme-based biosensors for on-line bioprocess monitoring and control has been slowed by problems relating to the in situ sterilizability of the probe and the stability of the enzyme component. A novel technology is presented here which addresses both of these difficulties. The …
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Manufacturing GMP-grade mRNA vaccine-associated Enzymes: Bioprocess Development and Economics
… methodology was employed, integrating bioprocess simulation in SuperPro Designer with capital and operating expenditure modelling, deterministic sensitivity analysis, and stochastic risk quantification through Monte Carlo simulation. Process models were constructed from mass and energy …
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A Bioelectrochemical Sensing System for Measuring Acidic Bioprocess Fermentation End Products
… is an important tool in the management of bioprocesses such as anaerobic digesters, wastewater treatment plants and bioelectrochemical systems. There are several important parameters which are considered for regular monitoring, including pH, temperature, conductivity, gas composition and …
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Characterization of Extremophilic Bacteria for Potential in the Biofuel and Bioprocess Industries
Industrial bioprocesses are constrained by the availability of microbes that are optimized for harsh bioprocess conditions. Over 500 soil and sediment samples collected from 77 saline and/or thermal sites in the continental United States, Hawaii, and Puerto Rico were used to inoculate fermentations …
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Development of an eicosapentaenoic acid production bioprocess using an indigenous microalgal isolate
… microalgal isolate suitable for an EPA bioprocess was selected by screening monoalgal isolates from the Council for Scientific and Industrial Research (CSIR) micro-algal culture collection. A Cymbella diatom (A23.2) was selected for superior EPA production in both growth and stress …
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BioSTEAM: The open-source bioprocess simulation and techno-economic analysis modules in Python
… emerging and conceptual processes. The Bioprocess Simulation and Techno-Economic Analysis Modules, BioSTEAM, is an open-source steady state process simulation package in python for preliminary TEA that will enable rigorous uncertainty analysis through its fast and flexible platform. …
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Combining Chemometrics and non-target GC-IMS gas phase analysis for improved bioprocess monitoring
… technologies is an active area of research. In bioprocess monitoring, most established PAT focuses on the liquid broth. A potential addition to established PAT is the analysis of volatile organic compounds (VOC) including microbial VOCs (mVOC), in the fermentation headspace. The hypothesis was, …
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Algal biomass production inhibition and adaptive bioprocess pathways via reutilization of hydrothermal liquefaction wastewater
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development
A critical early step in the development of a new biopharmaceutical is the selection of the master cell bank. Per FDA requirements, the same master cell bank must be used for all toxicity and clinical trials, as well as all production of the drug should it be commercialized. Developing a master …
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Optically pure D (-) lactic acid biosynthesis from diverse renewable biomass: microbial strain development and bioprocess analysis
Lactic acid is an important platform chemical that has long history and wide applications in food, polymer, pharmaceutics and cosmetic industries. Lactic acid has two optical isomers; namely D-lactic acid and L-lactic acid. Racemic mixture of lactic acid are usually used as preservatives and …
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A study of bioprocess designs for development of the myogenic secretome as a source of bioactive extracellular vesicles
The human skeletal muscle myoblasts (HSMM) secretome decreases cytokine-induced inflammation in chondrocytes, indicating potential as therapy for arthritis. The lack of an efficient scalable workflow for the human skeletal myoblast secretome limits its development as a source of therapeutic …
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Green Chemicals via Photosynthetic Microbial Factories: Integrating Metabolic and Bioprocess Engineering for 2-Phenylethanol Production and CO2 Valorization
L'abstract è presente nell'allegato / the abstract is in the attachment
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