Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"bioprinting"”.
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3D Bioprinting Pediatric Trachea
… extracellular matrix (ECM) into bioinks for 3D bioprinting patient specific, tissue engineered constructs. The results discussed in this dissertation show while ECM is a powerful mediator of cell behavior, its efficacy can be inhibited by chemical modification. Lastly, this work investigates an …
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3D bioprinting of pancreatic islets
Hintergrund/Ziel: Um Langzeitkomplikationen bei Diabetes mellitus Typ 1 (T1D) zu verhindern, können Spenderinseln transplantiert werden, was allerdings lebenslange rigorose Immunsuppression erfordert. Durch Verkapselung der Inselzellen kann die Immunsuppression umgangen werden, aber Upscaling ist …
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In situ bioprinting of the skin
… situ</italic> by using cartridge-based bioprinting to precisely deliver skin cells in a controlled manner in a wound.
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3D Bioprinting of Advanced Bioinks for Tissue Engineering Applications
… to the recently emerged three-dimensional (3D) bioprinting technology for the fabrication of functional tissue-engineered scaffold loaded with cells due to its ability to assemble complex structures with meticulous control over the entire fabrication process. It is a computer-assisted technology …
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TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING
… platform for engineering bone tissue using 3D bioprinting strategy has the capability of combining multiple clinically relevant biomaterials in biomimetic designs to improve outcomes for engineered bone graft substitutes. The aim of these explorations is to move outcomes toward clinical use and …
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Biofabrication of a Heart Wall Section using the FRESH Bioprinting Method
This dissertation addresses the challenge of bioprinting cardiac wall tissues. It focuses on three different aspects. The first is around materials that mimic the different cardiac wall tissue layers by testing the different materials pre- and post-crosslinked for their characteristics and …
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3D Bioprinting of High Cell Density Bioink for Chondrogenic Differentiation in Replacement Tracheal Rings
… were fabricated using a high cell density 3D bioprinting system into a support bath of oxidised, methacrylated alginate (OMA) hydrogel. A comprehensive characterisation of various formulations of the hydrogel was conducted to tabulate rheological and mechanical properties, and identify …
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Phase behaviour and structure formation of alginate-protein composite gels used in 3D bioprinting
… with a key application in extrusion-based 3D bioprinting. Alginate offers favourable printability and rapid ionic gelation but lacks cell-adhesive properties. Gelatin addresses these limitations by providing RGD motifs essential for cell attachment and enhancing scaffold porosity through …
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Novel Advances in Bioprinting Based on the Mechanical Design and Optimization of Open-source Systems
Three-dimensional (3D) bioprinting promises to be a practical solution for solving the increasing demand for organs and tissues. Several 3D bioprinters with different specifications are commercially available, but the impact on the field of tissue engineering (TE) is still limited, mainly due to …
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Development of a 3d bioprinting system, characterisation of bioink and printing microspheroids of hela cells
In Malaysia, Industrialised Building System (IBS) has been recognised as a potential solution in improving the deliverables of construction projects. However, the acceptance of this modern technology is still low. Most of the construction players prefer the conventional construction method which …
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Versatile multi-component (bio)ink platform for advanced biofabrication
… aims to advance tissue engineering through bioprinting, addressing the need for innovative solutions to restore tissue function and tackle organ shortages. Bioprinting, which integrates 3D printing with biological materials to create "bioinks," has significant potential but is hindered by …
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The development of novel hybrid poly (2-oxazoline)-based bioinks for 3D bioprinting: a comparative study with Pluronic F127
Bioprinting has emerged as a cutting-edge technology to overcome the shortage of tissues and organs by the precise deposition of living cells and biomaterials into three-dimensional (3D) biomimetic constructs. However, the inadequate choice of bioinks has limited its widespread implementation and …
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Strategies to design and optimize natural polymers as biomaterial inks for musculoskeletal tissue engineering applications
Three-dimensional bioprinting is an advanced fabrication technology which exploits additive manufacturing techniques to develop scaffolds with precise spatial control for biomedical applications. Among the existing technologies, extrusion-based bioprinting gained an increased interest in …
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Engineering Dynamic Granular Composites for the Repair of Cartilage Tissue
… repair, dynamic tissue shape morphing, and 4D bioprinting, where features such as microgel micromechanical properties, volume ratios of spheroids and microgels, rate of microgel degradation, and overall spatial positioning of granular composites were controlled. First, the micromechanical …
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Engineering of tools for De Novo Assembly of Human Cells
… approaches, such as microfluidics and 3D bioprinting, provide spatial control by patterning cell types with high resolution, but face challenges in reproducing physiologically accurate cell types and interactions. Bottom-up methods, such as organoids, induce pluripotent cells to …
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The Influence of Manufacturing Method and Collagen on the Mechanical Performance of Sodium Alginate-Based Scaffolds for Cartilage Tissue Engineering
… such as sodium alginate (SA) have been used in bioprinting and tissue engineering for their favourable properties, however, the mechanical performance of engineered tissue requires improvement. In the present work, the mechanical properties of pure-SA scaffolds were compared with various …
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Development of a methodology for applying shear stress to suspended mammalian cells
… stress in situations such as microfluidics, bioprinting and bioreactors. Being exposed to such stresses alters cell integrity, which affects their downstream applications, including drug screening and tissue regeneration. Current methods of loading shear stress onto suspended cells can be …
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Closed-loop Tool Path Planning for Non-planar Additive Manufacturing and Sensor-based Inspection on Stationary and Moving Freeform Objects
… fabrication of conformal electronics, in situ bioprinting, and spatiotemporal biosensing: i. A non-planar tool path planning algorithm for conformal microextrusion 3D printing based on point cloud data representations of object geometry was presented. Also, new insights into the origin of …
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